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Identification of a cholesterol-binding pocket in inward rectifier K(+) (Kir) channels

Author(s): Fürst O; Nichols CG; Lamoureux G; D' Avanzo N;

Cholesterol is the major sterol component of all mammalian plasma membranes. Recent studies have shown that cholesterol inhibits both bacterial (KirBac1.1 and KirBac3.1) and eukaryotic (Kir2.1) inward rectifier K(+) (Kir) channels. Lipid-sterol interactions ...

Article GUID: 25517146


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