Author(s): Walsh NA; Phillips EM; Páez A; Cross NE; Dang-Vu TT; Perrault AA;

Mounting evidence shows sex-based differences in sleep experiences and outcomes, including the prevalence of insomnia disorder. However, the impact of biological sex on brain oscillations during sleep remains poorly understood, especially in the context of insomnia disorder. This is a notable gap, given that neurophysiological aspects of sleep are associa ...

Article GUID: 42331757

Author(s): Runge N; Walsh N; Dang-Vu TT; De Baets L; Labie C; Bilterys T; Verschueren S; Van Assche D; Nijs J; Malfliet A; Danneels L; Ickmans K; Moens M; Goubert D; Mairesse O; Paez A;

Chronic spinal pain is associated with fragmented sleep, yet the neurophysiological mechanisms linking the two remain unclear. Given their role in sensory gating and sleep stability, sleep spindles may represent a key mechanism connecting chronic spinal pain and sleep fragmentation. This study ex ...

Article GUID: 42186730

Author(s): Paez A; Dogaheh SB; Gillman SO; Carnes A; Dakterzada F; Barbe F; Piñol-Ripoll G; Dang-Vu TT;

Background: Sleep is essential for brain-health, including clearance of ß-amyloid (Aß), tau, and otherpromising diagnostic markers of neurodegeneration and progression in Alzheimer's Disease (AD): cerebrospinal fluid neurofilament-light chain (NfL), neurogranin-36 (NG-36), an ...

Article GUID: 41512123

Author(s): Paez A; Piñol-Ripoll G; Dogaheh SB; Gillman SO; Dakterzada F; Carnes A; Barbe F; Dang-Vu TT;

Background: Cerebrospinal fluid (CSF) orexin levels are higher in MCI and AD and associated with sleep deterioration, increasing risk of cognitive decline and Alzheimer's disease (AD) progression. Orexin-A is a key sleep-wake cycle regulator. Dual orexin receptor antagonists ...

Article GUID: 41512277

Author(s): Páez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbé F; Dang-Vu TT; Ripoll GP;

Introduction: Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset. Methods: Using data from a prospective cohort of mild to moderate AD (n = 60), we analyzed non-rapid eye moveme ...

Article GUID: 39878233