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Predicted coronavirus Nsp5 protease cleavage sites in the human proteome

Author(s): Scott BM; Lacasse V; Blom DG; Tonner PD; Blom NS;

Background: The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also been found to cleave host proteins, dis ...

Article GUID: 35379171


Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

Author(s): Scott BM; Gutiérrez-Vázquez C; Sanmarco LM; da Silva Pereira JA; Li Z; Plasencia A; Hewson P; Cox LM; O' Brien M; Chen SK; Moraes-Vieira ...

Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host ...

Article GUID: 34183837


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