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Cardiac gene delivery using ultrasound: State of the field

Author(s): Singh D; Memari E; He S; Yusefi H; Helfield B;

Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explo ...

Article GUID: 38983873


Stable Cavitation-Mediated Delivery of miR-126 to Endothelial Cells

Author(s): He S; Singh D; Yusefi H; Helfield B;

In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia. Novel ultrasound-stimulated microbubbles offer a means to deli ...

Article GUID: 36559150


An Overview of Cell Membrane Perforation and Resealing Mechanisms for Localized Drug Delivery

Author(s): He S; Singh D; Helfield B;

Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease. Indeed, the plasma membrane represents a significant barrier to successful del ...

Article GUID: 35456718


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