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Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region

Author(s): Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S; ...

Objective: We aimed to examine the effect of age of obesity onset, sex, and their interaction on abdominal and femoral subcutaneous adipose tissue (SAT) morphology (degree of adipocyte hyperplasia ...

Article GUID: 39045668


Senescence markers in subcutaneous preadipocytes differ in childhood- versus adult-onset obesity before and after weight loss

Author(s): Murphy J; Tam BT; Kirkland JL; Tchkonia T; Giorgadze N; Pirtskhalava T; Tsoukas MA; Morais JA; Santosa S; ...

Objective: The aim of this study was to determine the effect of age of obesity onset on senescence-related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before and a ...

Article GUID: 37194560


Sex Affects Regional Variations in Subcutaneous Adipose Tissue T Cells but not Macrophages in Adults with Obesity

Author(s): Murphy J; Delaney KZ; Dam V; Tam BT; Khor N; Tsoukas MA; Morais JA; Santosa S;

Objective: The inflammatory environment in lower-body subcutaneous adipose tissue (SAT) has been largely unexplored. This study aimed to examine the effects of region (upper body vs. lower body) and sex on SAT immune cell profiles in young adults with obesi ...

Article GUID: 33179451


Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity.

Author(s): Tam BT, Murphy J, Khor N, Morais JA, Santosa S

Although childhood-onset obesity (CO) and adult-onset obesity (AO) are known to lead to distinctive clinical manifestations and disease risks, the fundamental differences between them are largely unclear. The aim of the current study is to investigate the f ...

Article GUID: 32808657


Obestatin and growth hormone reveal the interaction of central obesity and other cardiometabolic risk factors of metabolic syndrome.

Author(s): Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM

Sci Rep. 2020 Mar 26;10(1):5495 Authors: Yu AP, Ugwu FN, Tam BT, Lee PH, Ma V, Pang S, Chow AS, Cheng KK, Lai CW, Wong CS, Siu PM

Article GUID: 32218464


Obesity and ageing: Two sides of the same coin.

Author(s): Tam BT, Morais JA, Santosa S

Obes Rev. 2020 Feb 05;: Authors: Tam BT, Morais JA, Santosa S

Article GUID: 32020741


Ghrelin Axis Reveals the Interacting Influence of Central Obesity and Hypertension.

Author(s): Yu AP, Ugwu FN, Tam BT, Lee PH, Lai CW, Wong CSC, Siu PM

Front Endocrinol (Lausanne). 2018;9:534 Authors: Yu AP, Ugwu FN, Tam BT, Lee PH, Lai CW, Wong CSC, Siu PM

Article GUID: 30258404


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