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Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains com ...

Article GUID: 38596311


Polarization and cell-fate decision facilitated by the adaptor Ste50p in Saccharomyces cerevisiae

Author(s): Sharmeen N; Law C; Wu C;

In response to pheromone, many proteins localize on the plasma membrane of yeast cell to reform it into a polarized shmoo structure. The adaptor protein Ste50p, known as a pheromone signal enhancer critical for shmoo polarization, has never been explored sy ...

Article GUID: 36538537


Role of tau protein on the photophysical properties of fluorescent carbon dots

Author(s): Camilus NS; Lucas S; Wu C; Naccache R; Martic S;

Background: Globally, a number of individuals who live with Alzheimer's disease (AD), an incurable and debilitating disease, is increasing. Tau protein has a structural role, maintains integrity of microtubules and is one of the underlying causes of the ...

Article GUID: 34971135


The adaptor protein Ste50 directly modulates yeast MAPK signaling specificity through differential connections of its RA domain.

Author(s): Sharmeen N, Sulea T, Whiteway M, Wu C

Mol Biol Cell. 2019 03 15;30(6):794-807 Authors: Sharmeen N, Sulea T, Whiteway M, Wu C

Article GUID: 30650049


Comparison of Electronic and Physicochemical Properties between Imidazolium-Based and Pyridinium-Based Ionic Liquids.

Author(s): Wu C, De Visscher A, Gates ID

J Phys Chem B. 2018 07 05;122(26):6771-6780 Authors: Wu C, De Visscher A, Gates ID

Article GUID: 29889524


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