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Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains com ...

Article GUID: 38596311


A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase

Author(s): Ayan S; Rotaru AM; Kaye EG; Juneau G; Das S; Wilds CJ; Beharry AA;

Fluorescent chemosensors offer a direct means of measuring enzyme activity for cancer diagnosis, predicting drug resistance, and aiding in the discovery of new anticancer drugs. O6-methylguanine DNA methyltransferase (MGMT) is a predictor of resistance towa ...

Article GUID: 38502038


Development of a Bayesian inference model for assessing ventilation condition based on CO2 meters in primary schools

Author(s): Hou D; Wang LL; Katal A; Yan S; Zhou LG; Wang V; Vuotari M; Li E; Xie Z;

Outdoor fresh air ventilation plays a significant role in reducing airborne transmission of diseases in indoor spaces. School classrooms are considerably challenged during the COVID-19 pandemic because of the increasing need for in-person education, untimel ...

Article GUID: 36035815


Evaluating SARS-CoV-2 airborne quanta transmission and exposure risk in a mechanically ventilated multizone office building

Author(s): Yan S; Wang LL; Birnkrant MJ; Zhai J; Miller SL;

The world has faced tremendous challenges during the COVID-19 pandemic since 2020, and effective clean air strategies that mitigate infectious risks indoors have become more essential. In this study, a novel approach based on the Wells-Riley model applied t ...

Article GUID: 35602249


Structural organization and phase behaviour of meta-substituted dioctadecylaminobenzoquinones at the air/water interface.

Author(s): Behyan S, Gritzalis D, Schmidt R, Kebede E, Cuccia LA, DeWolf C

Phys Chem Chem Phys. 2019 Jan 30;21(5):2345-2350 Authors: Behyan S, Gritzalis D, Schmidt R, Kebede E, Cuccia LA, DeWolf C

Article GUID: 30657501


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