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Cardiac gene delivery using ultrasound: State of the field

Author(s): Singh D; Memari E; He S; Yusefi H; Helfield B;

Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explo ...

Article GUID: 38983873


Subharmonic resonance of phospholipid coated ultrasound contrast agent microbubbles

Author(s): Yusefi H; Helfield B;

Phospholipid encapsulated ultrasound contrast agents have proven to be a powerful addition in diagnostic imaging and show emerging applications in targeted therapy due to their resonant and nonlinear scattering. Microbubble response is affected by their int ...

Article GUID: 38217906


Fluid flow influences ultrasound-assisted endothelial membrane permeabilization and calcium flux

Author(s): Memari E; Hui F; Yusefi H; Helfield B;

The local fluid dynamics experienced by circulating microbubbles vary across different anatomical sites, which can influence ultrasound-mediated therapeutic delivery efficacy. This study aimed to elucidate the effect of fluid flow rate in combination with r ...

Article GUID: 37150403


Stable Cavitation-Mediated Delivery of miR-126 to Endothelial Cells

Author(s): He S; Singh D; Yusefi H; Helfield B;

In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia. Novel ultrasound-stimulated microbubbles offer a means to deli ...

Article GUID: 36559150


The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles

Author(s): Yusefi H; Helfield B;

Ultrasound-driven microbubbles, typically between 1 and 8 µm in diameter, are resonant scatterers that are employed as diagnostic contrast agents and emerging as potentiators of targeted therapies. Microbubbles are administered in populations whereby their ...

Article GUID: 36223708


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