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Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders

Author(s): Ismaylova E; Nemoda Z; Booij L;

Introduction: Eating disorders are characterized by maladaptive eating behaviors and preoccupations around body shape, weight, and eating. The serotonin system has been among the most widely studied neurobiological factors in relation to eating disorders. Recent research also highlighted the role of oxytocin. Aims and methods: This article aims to review ...

Article GUID: 39745000


Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement

Author(s): Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L;

Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understanding of insomnia and its treatment. To date, no study has examined the relationship between K-complexes ...

Article GUID: 39739397


Modeling predicts facile release of nitrite but not nitric oxide from the thionitrate CH3SNO2 with relevance to nitroglycerin bioactivation

Author(s): Parmar V; Orabi EA; English AM; Peslherbe GH;

Nitroglycerin is a potent vasodilator in clinical use since the late 1800s. It functions as a prodrug that is bioactivated by formation of an enzyme-based thionitrate, E-Cys-NO2. This intermediate reportedly decomposes to release NO and NO2- but their relative yields remain controversial. Hence, we determined barriers for NO and NO2- production from the m ...

Article GUID: 39738238


PreVISE: an efficient virtual reality system for SEEG surgical planning

Author(s): Spiegler P; Abdelsalam H; Hellum O; Hadjinicolaou A; Weil AG; Xiao Y;

Epilepsy is a neurological disorder characterized by recurring seizures that can cause a wide range of symptoms. Stereo-electroencephalography (SEEG) is a diagnostic procedure where multiple electrodes are stereotactically implanted within predefined brain regions to identify the seizure onset zone, which needs to be surgically removed or disconnected to ...

Article GUID: 39735694


Widespread admixture blurs population structure and confounds Lake Trout (Salvelinus namaycush) conservation even in the genomic era

Author(s): Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ;

Intraspecific variation is important for species' long-term persistence in changing environments. Conservation strategies targeting intraspecific variation often rely on the identification of management or policy units below the species level based on biological differences among populations. ...

Article GUID: 39730611


A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [18F]fallypride positron emission tomography

Author(s): Nikolic M; Cox SML; Jaworska N; Castellanos-Ryan N; Dagher A; Vitaro F; Brendgen M; Parent S; Boivin M; Côté S; Tremblay RE; Séguin JR; Leyton M;

Background: Adolescent alcohol use is the norm, but only some develop a substance use disorder. The increased risk might reflect heightened mesocorticolimbic responses to reward-related cues but results published to date have been inconsistent. Methods: Young social drinkers (age 18.5 ± 0.6 y.o. ...

Article GUID: 39725679


Progesterone and allopregnanolone facilitate excitatory synaptic transmission in the infralimbic cortex via activation of membrane progesterone receptors

Author(s): Rahaei N; Buynack LM; Kires L; Movasseghi Y; Chapman CA;

Estrogens and progesterone can have rapid effects on neuronal function and can modify the use of spatial navigation strategies dependent upon the prefrontal cortex, striatum, and hippocampus. Here, we assessed the effects of 17ß-estradiol (E2), progesterone, and its metabolite allopregnanolone, on evoked excitatory postsynaptic potentials in the infralimb ...

Article GUID: 39722289


Butyl Acrylate/2-Methylene-1,3-Dioxepane/Vinyl Acetate Emulsion Terpolymerization: Incorporating Backbone Degradable Linkages into Adhesive Applications

Author(s): Meek K; Movafagh M; Dubé MA;

The ring-opening polymerization of bio-based monomer 2-methylene-1,3-dioxepane (MDO) can reportedly enhance polymer degradability. Butyl acrylate (BA)/MDO/vinyl acetate (VAc) terpolymers were synthesized via emulsion polymerization for their eventual application as pressure-sensitive adhesives (PSAs). While using MDO in emulsion polymerization leads to a ...

Article GUID: 39719378


Virtual reality-based preoperative planning for optimized trocar placement in thoracic surgery: A preliminary study

Author(s): Harirpoush A; Rakovich G; Kersten-Oertel M; Xiao Y;

Video-assisted thoracic surgery (VATS) is a minimally invasive approach for treating early-stage non-small-cell lung cancer. Optimal trocar placement during VATS ensures comprehensive access to the thoracic cavity, provides a panoramic endoscopic view, and prevents instrument crowding. While established principles such as the Baseball Diamond Principle (B ...

Article GUID: 39720764


Insights from multiple stable isotopes (C, N, Cl) into the photodegradation of herbicides atrazine and metolachlor

Author(s): Levesque-Vargas M; Ohlund L; Sleno L; Gélinas Y; Höhener P; Ponsin V;

Many processes can contribute to the attenuation of the frequently detected and toxic herbicides atrazine and metolachlor in surface water, including photodegradation. Multi-element compound-specific isotope analysis has the potential to decipher between these different degradation pathways as Cl is a promising tool for both pathway identification and a s ...

Article GUID: 39716600


The effect of micro-vessel viscosity on the resonance response of a two-microbubble system

Author(s): Yusefi H; Helfield B;

Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1-8 µm in diameter, with a volume-weighted mean size of 2-3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing success as a local therapeutic vector, the fundamental interplay between microbubbles - including bubbl ...

Article GUID: 39705920


Two-dimensional Nanosheets by Liquid Metal Exfoliation

Author(s): Bai Y; Xu Y; Sun L; Ward Z; Wang H; Ratnayake G; Wang C; Zhao M; He H; Gao J; Wu M; Lu S; Bepete G; Peng D; Liu B; Kang F; Terrones H; Terrones M; Lei Y;

Liquid exfoliation is a scalable and effective method for synthesizing 2D nanosheets (NSs) but often induces contamination and defects. Here, liquid metal gallium (Ga) is used to exfoliate bulk layered materials into 2D NSs at near room temperature, utilizing the liquid surface tension and Ga int ...

Article GUID: 39707650


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