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Electroconductive Collagen-Carbon Nanodots Nanocomposite Elicits Neurite Outgrowth, Supports Neurogenic Differentiation and Accelerates Electrophysiological Maturation of Neural Progenitor Spheroids

Author(s): Lomboni DJ; Ozgun A; de Medeiros TV; Staines W; Naccache R; Woulfe J; Variola F;

Neuronal disorders are characterized by the loss of functional neurons and disrupted neuroanatomical connectivity, severely impacting the quality of life of patients. This study investigates a novel electroconductive nanocomposite consisting of glycine-derived carbon nanodots (GlyCNDs) incorporated into a collagen matrix and validates its beneficial physi ...

Article GUID: 37922888


Medical Cannabis Use Among Canadian Veterans and Non-Veterans: A National Survey

Author(s): Valikhanova G; Kato Y; Fitzcharles MA; Ware M; Da Costa D; Lowensteyn I; Cheung HS; Grover S;

Background: Medical cannabis (MC) is used by Canadian Veterans to manage a wide range of health issues. However, there is little information comparing the reasons for MC use and its perceived effectiveness between Veterans and non-Veterans. Objects: We compared MC use among a convenience sample ...

Article GUID: 37920683


Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections

Author(s): Feng Y; Lu H; Whiteway M; Jiang Y;

Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) caused by Candida species. However, the mechanisms of FLC tolerance in Candida species remain to be fully ...

Article GUID: 37918789


Striking a balance: triage and crisis intervention models within the pediatric emergency room

Author(s): Laporte N; Hechtman L; Rousseau C; Greenfield B;

No abstract available

Article GUID: 37920538


Bayesian workflow for the investigation of hierarchical classification models from tau-PET and structural MRI data across the Alzheimer's disease spectrum

Author(s): Belasso CJ; Cai Z; Bezgin G; Pascoal T; Stevenson J; Rahmouni N; Tissot C; Lussier F; Rosa-Neto P; Soucy JP; Rivaz H; Benali H;

Background: Alzheimer's disease (AD) diagnosis in its early stages remains difficult with current diagnostic approaches. Though tau neurofibrillary tangles (NFTs) generally follow the stereotypical pattern described by the Braak staging scheme, the network degeneration hypothesis (NDH) has su ...

Article GUID: 37920382


Solar neighborhoods: the impact of urban layout on a large-scale solar strategies application

Author(s): Singh K; Hachem-Vermette C; D' Almeida R;

The article addresses the challenges of evaluating energy performance in different neighborhood settings under various energy efficiency measures and proposes a methodology for selecting appropriate solar strategies on a neighborhood scale. The study selects five representative neighborhoods from various climatic zones with different building and street l ...

Article GUID: 37914754


Actovegin improves skeletal muscle mitochondrial respiration and functional aerobic capacity in a type 1 diabetic male murine model

Author(s): Kosik B; Larsen S; Bergdahl A;

Insulin deficiency in type 1 diabetes (T1D) leads to an impairment of glucose metabolism and mitochondrial function. Actovegin is a hemodialysate of calf blood, which has been shown to enhance glucose uptake and cell metabolism in healthy human skeletal muscle. The objectives of this study were to determine the effects of Actovegin on skeletal muscle mito ...

Article GUID: 37913525


Superhydrophilic CoFe Dispersion of Hydrogel Electrocatalysts for Quasi-Solid-State Photoelectrochemical Water Splitting

Author(s): Wang H; Gao RT; Nguyen NT; Bai J; Ren S; Liu X; Zhang X; Wang L;

Photoelectrochemical (PEC) water splitting is an attractive strategy to convert solar energy to hydrogen. However, the lifetime of PEC devices is restricted by the photocorrosion of semiconductors and the instability of co-catalysts. Herein, we report a feasible in situ inherent cross-linking method for stabilizing semiconductors that uses a CoFe-disperse ...

Article GUID: 37901939


School Experiences and Anxiety Trajectories Among Youth with Intellectual Disabilities

Author(s): Dubé C; Morin AJS; Olivier E; Gilbert W; Tracey D; Craven RG; Maïano C;

This study investigated how the school experiences and personal characteristics of youth with Intellectual Disabilities (ID) contribute to their longitudinal trajectories of anxiety. To this end, we relied on a sample of 390 youth with mild (48.2%) to moderate (51.8%) levels of ID, aged from 11 to 22 (M = 15.70), and recruited in Canada (n = 140) and Aust ...

Article GUID: 37898583


Heterogeneous dispersal networks to improve biodiversity science

Author(s): Savary P; Lessard JP; Peres-Neto PR;

Dispersal has a key role in shaping spatial patterns of biodiversity, yet its spatial heterogeneity is often overlooked in biodiversity analyses and management strategies. Properly parameterised heterogeneous dispersal networks capture the complex interplay between landscape structure and species-specific dispersal capacities. However, this heterogeneity ...

Article GUID: 37891075


Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

Author(s): Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT;

Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C. albicans can initiate a strong drug tolerance response that allows some cells to ...

Article GUID: 37888959


Winter's Topography, Law, and the Colonial Legal Imaginary in British Columbia

Author(s): Matthew P Unger

This article examines how images of nature, weather, and topography disclose a politics of recognition (who is visible/invisible) invested in a burgeoning criminal justice milieu, where punishment of wrongdoing became increasingly racialized in British Columbia during the early confederation period of Canada's history. Drawing from archived court docu ...

Article GUID: 37885918


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