Author(s): Rousseau PN; Chakravarty MM; Steele CJ;

The cerebellum's involvement in cognitive, affective and motor functions is mediated by connections to different regions of the cerebral cortex. A distinctive feature of cortico-cerebellar loops that has been demonstrated in the animal work is a topographic organization that is preserved across its corticopontine, pontocerebellar, and cerebello-thalmo ...

Article GUID: 36252913

Author(s): Olajide OJ; La Rue C; Bergdahl A; Chapman CA;

Increasing evidence suggests that mitochondrial dysfunction and aberrant release of mitochondrial reactive oxygen species (ROS) play crucial roles in early synaptic perturbations and neuropathology that drive memory deficits in Alzheimer's disease (AD). We recently showed that solubilized human amyloid beta peptide 1-42 (hAß1-42) causes rapid alterati ...

Article GUID: 36275011

Author(s): Valyear MD; LeCocq MR; Brown A; Villaruel FR; Segal D; Chaudhri N;

Rationale: Alcohol use is reliably preceded by discrete and contextual stimuli which, through diverse learning processes, acquire the capacity to promote alcohol use and relapse to alcohol use. Objective: We review contemporary extinction, renewal, reinstatement, occasion setting, and sex differences research within a conditioning framework of relapse to ...

Article GUID: 36264342

Author(s): Devine S; Neumann C; Levari D; Eppinger B;

Prevalence-induced concept change describes a cognitive mechanism by which someone's definition of a concept shifts as the prevalence of instances of that concept changes. While this phenomenon has been established in young adults, it is unclear how it affects older adults. In this study, we explore how prevalence-induced concept change affects older ...

Article GUID: 36253591

Author(s): Wang Z; Bian Y; Xu Y; Zheng C; Jiang Q; An C;

id="eng-abstract">
Fresh biochar has been widely applied to the remediation of heavy metals in soil by its property of adsorption, but the changes in its physicochemical properties and in situ adsorption performance over time cannot be ignored. In this study, the sorption of Cd²⁺ by corn straw biochars (CB) and mun ...

Article GUID: 36251198

Author(s): Cai Z; Pellegrino G; Lina JM; Benali H; Grova C;

Investigating the relationship between task-related hemodynamic responses and cortical excitability is challenging because it requires simultaneous measurement of hemodynamic responses while applying noninvasive brain stimulation. Moreover, cortical excitability and task-related hemodynamic responses are both associated with inter-/intra-subject variabili ...

Article GUID: 36250709

Author(s): Samaei A; Deshmukh SS; Protheroe C; Nyéki S; Tremblay-Ethier RA; Kálmán L;

The influence of illumination history of native bacterial reaction centers (BRCs) on the ability of binding and photo-induced oxidation of manganous ions was investigated in the pH range between 8.0 and 9.4. Binding of manganous ions to a buried site required 6 to 11-fold longer incubation periods, depending on the pH, in dark-adapted BRCs than in BRCs th ...

Article GUID: 36216075

Author(s): Abdar M; Salari S; Qahremani S; Lam HK; Karray F; Hussain S; Khosravi A; Acharya UR; Makarenkov V; Nahavandi S;

The COVID-19 (Coronavirus disease 2019) pandemic has become a major global threat to human health and well-being. Thus, the development of computer-aided detection (CAD) systems that are capable of accurately distinguishing COVID-19 from other diseases using chest computed tomography (CT) and X-r ...

Article GUID: 36217534

Author(s): Golden CK; Kazmirchuk TDD; McNally EK; El Eissawi M; Gokbayrak ZD; Richard JD; Brett CL;

Diverse physiology relies on receptor and transporter protein down-regulation and degradation mediated by ESCRTs. Loss-of-function mutations in human ESCRT genes linked to cancers and neurological disorders are thought to block this process. However, when homologous mutations are introduced into model organisms, cells thrive and degradation persists, sugg ...

Article GUID: 36215320

Author(s): Hansen JY; Markello RD; Tuominen L; Nørgaard M; Kuzmin E; Palomero-Gallagher N; Dagher A; Misic B;

Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcript ...

Article GUID: 36209794

Author(s): Gálvez Á; Peres-Neto PR; Castillo-Escrivà A; Bonilla F; Camacho A; García-Roger EM; Iepure S; Miralles-Lorenzo J; Monrós JS; Olmo C; Picazo A; Rojo C; Rueda J; Sahuquillo M; Sasa M; Segura M; Armengol X; Mesquita-Joanes F;

The metacommunity concept provides a theoretical framework that aims at explaining organism distributions by a combination of environmental filtering, dispersal, and drift. However, few works have attempted a multitaxon approach and even fewer have compared two distant biogeographical regions usi ...

Article GUID: 36199222

Author(s): Wu G; Eastwood C; Zeng Y; Quan H; Long Q; Zhang Z; Ghali WA; Bakal J; Boussat B; Flemons W; Forster A; Southern DA; Knudsen S; Popowich B; Xu Y;

Background: Measurement of care quality and safety mainly relies on abstracted administrative data. However, it is well studied that administrative data-based adverse event (AE) detection methods are suboptimal due to lack of clinical information. Electronic medical records (EMR) have been widely ...

Article GUID: 36197944