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Frailty, e-health and prevention of late-onset Alzheimer disease and related disorders: it is time to take action

Author(s): Beauchet O; Galery K; Lafontaine C; Sawchuk K; Plonka A; Gros A; Allali G;

No abstract

Article GUID: 35334089


Sentiment Classification Method Based on Blending of Emoticons and Short Texts

Author(s): Zou H; Xiang K;

With the development of Internet technology, short texts have gradually become the main medium for people to obtain information and communicate. Short text reduces the threshold of information production and reading by virtue of its short length, which is in line with the trend of fragmented reading in the context of the current fast-paced life. In additi ...

Article GUID: 35327909


Supplementary dataset of context-dependent conditioned responding to an alcohol-predictive cue in female and male rats

Author(s): Segal D; Valyear MD; Chaudhri N;

This supplementary dataset is supportive of the research article entitled 'The role of context on responding to an alcohol-predictive cue in female and male rats' [1]. This article describes the raw data pertaining to the behaviour of male and female rats during intermittent to ethanol and Pavlovian conditioning training and testing procedures. Sp ...

Article GUID: 35330738


A portrait of obstructive sleep apnea risk factors in 27,210 middle-aged and older adults in the Canadian Longitudinal Study on Aging

Author(s): Thompson C; Legault J; Moullec G; Baltzan M; Cross N; Dang-Vu TT; Martineau-Dussault MÈ; Hanly P; Ayas N; Lorrain D; Einstein G; Carrier J; Gosselin N;

Determining the prevalence and characteristics of individuals susceptible to present with obstructive sleep apnea (OSA) is essential for developing targeted and efficient prevention and screening strategies. We included 27,210 participants aged =45 years old (50.3% women) from the Canadian Longit ...

Article GUID: 35332170


Should Burnout Be Conceptualized as a Mental Disorder?

Author(s): Nadon L; De Beer LT; Morin AJS;

Burnout is generally acknowledged by researchers, clinicians, and the public as a pervasive occupational difficulty. Despite this widespread recognition, longstanding debates remain within the scientific community regarding its definition and the appropriateness of classifying burnout as its own pathological entity. The current review seeks to address whe ...

Article GUID: 35323401


Dynamics of SARS-CoV-2 spreading under the influence of environmental factors and strategies to tackle the pandemic: A systematic review

Author(s): Asif Z; Chen Z; Stranges S; Zhao X; Sadiq R; Olea-Popelka F; Peng C; Haghighat F; Yu T;

COVID-19 is deemed as the most critical world health calamity of the 21st century, leading to dramatic life loss. There is a pressing need to understand the multi-stage dynamics, including transmission routes of the virus and environmental conditions due to the possibility of multiple waves of COVID-19 in the future. In this paper, a systematic examinatio ...

Article GUID: 35317188


Combination of system biology and classical approaches for developing biorefinery relevant lignocellulolytic Rasamsonia emersonii strain

Author(s): Raheja Y; Singh V; Kaur B; Basotra N; Di Falco M; Tsang A; Singh Chadha B;

The objective of this study was to develop thermophilic fungus Rasamsonia emersonii using integrated system biology tools (genomics, proteomics and transcriptional analysis) in combination with classical strain breeding approaches. Developed hyper cellulolytic mutant strain M36 showed endoglucanase (476.35 U/ml), ß-glucosidase (70.54 U/ml), cellobiohydrol ...

Article GUID: 35318142


Human-level COVID-19 diagnosis from low-dose CT scans using a two-stage time-distributed capsule network

Author(s): Afshar P; Rafiee MJ; Naderkhani F; Heidarian S; Enshaei N; Oikonomou A; Babaki Fard F; Anconina R; Farahani K; Plataniotis KN; Mohammadi A;

Reverse transcription-polymerase chain reaction is currently the gold standard in COVID-19 diagnosis. It can, however, take days to provide the diagnosis, and false negative rate is relatively high. Imaging, in particular chest computed tomography (CT), can assist with diagnosis and assessment of ...

Article GUID: 35318368


A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers

Author(s): Nasr MA; Timmins LR; Martin VJJ; Kwan DH;

Allosteric transcription factor (aTF) biosensors are valuable tools for engineering microbes toward a multitude of applications in metabolic engineering, biotechnology, and synthetic biology. One of the challenges toward constructing functional and diverse biosensors in engineered microbes is the limited toolbox of identified and characterized aTFs. To ov ...

Article GUID: 35316041


Global urban environmental change drives adaptation in white clover

Author(s): Santangelo JS; Ness RW; Cohan B; Fitzpatrick CR; Innes SG; Koch S; Miles LS; Munim S; Peres-Neto PR; Prashad C; Tong AT; Aguirre WE; Akinwole PO; Alberti M; Álvarez J; Anderson JT; Anderson JJ; Ando Y; Andrew NR; Angeoletto F; Anstett DN ...

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense th ...

Article GUID: 35298255


Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice

Author(s): Rawlins LE; Almousa H; Khan S; Collins SC; Milev MP; Leslie J; Saint-Dic D; Khan V; Hincapie AM; Day JO; McGavin L; Rowley C; Harlalka GV; Vancollie VE; Ahmad W; Lelliott CJ; Gul A; Yalcin B; Crosby AH; Sacher M; Baple EL;

The highly evolutionarily conserved transport protein particle (TRAPP) complexes (TRAPP II and III) perform fundamental roles in subcellular trafficking pathways. Here we identified biallelic sequence alterations in TRAPPC10, a component of the TRAPP II complex, in individuals with a severe micro ...

Article GUID: 35298461


Social gradients in ADHD by household income and maternal education exposure during early childhood: Findings from birth cohort studies across six countries

Author(s): Nicholas James Spencer

CONCLUSION: Findings indicate that children in families with high household income or maternal education are less likely to have ADHD at age 9-11. Absolute inequality, in combination with relative inequality, provides a more complete account of the socioeconomic status and ADHD relationship in different high-income countries. While the study design preclu ...

Article GUID: 35294456


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