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Understanding Sensitive Period Effects in Musical Training

Author(s): Virginia B Penhune

Adult ability in complex cognitive domains, including music, is commonly thought of as the product of gene-environment interactions, where genetic predispositions influence and are modulated by experience, resulting in the final phenotypic expression. Recently, however, the important contribution of maturation to gene-environment interactions has become b ...

Article GUID: 34435343


The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

Author(s): Paquola C; Royer J; Lewis LB; Lepage C; Glatard T; Wagstyl K; DeKraker J; Toussaint PJ; Valk SL; Collins DL; Khan A; Amunts K; Evans AC; Dickscheid T; Bernhardt BC;

Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is 'BigBrain'. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, 'BigBra ...

Article GUID: 34431476


A Multilevel Person-Centered Examination of Teachers' Workplace Experiences: Replication and Extension With Links to Instructional Support and Achievement

Author(s): Collie RJ; Martin AJ; Morin AJS; Malmberg LE; Sammons P;

In a replication and extension of an earlier study, we relied on person-centered analyses to identify teacher (Level 1) and school (Level 2) profiles based on teachers' experiences of job demands (barriers to professional development, disruptive student behavior), job resources (teacher collaboration, input in decision-making), and personal resources ...

Article GUID: 34421763


Dynamic Covalent Polyurethane Network Materials: Synthesis and Self-healability

Author(s): Nellepalli P; Patel T; Oh JK;

Polyurethane (PU) has not only been widely used in our daily lives, but also extensively explored as an important class of the essential polymers for various applications. In recent years significant efforts have been made on the development of self-healable PU materials that possess high performance, extended lifetime, great reliability, and recyclabilit ...

Article GUID: 34418209


Design, structure-activity relationship study and biological evaluation of the thieno[3,2-c]isoquinoline scaffold as a potential anti-cancer agent

Author(s): Liu JT; Jaunky DB; Larocque K; Chen F; Mckibbon K; Sirouspour M; Taylor S; Shafeii A; Campbell D; Braga H; Piekny A; Forgione P;

Several derivatives of a series that share a thienoisoquinoline scaffold have demonstrated potent anti-cancer activity against cancer cell lines A549, HeLa, HCT-116 in the submicromolar concentration range. Structure-activity relationship (SAR) studies on a range of derivatives aided in identifyi ...

Article GUID: 34416378


The effects of evening high-intensity exercise on sleep in healthy adults: A systematic review and meta-analysis

Author(s): Frimpong E; Mograss M; Zvionow T; Dang-Vu TT;

Moderate-intensity exercise is generally recommended for improving sleep, whereas, high-intensity exercise (HIE) prior to bedtime is often discouraged. We conducted a systematic review and meta-analysis to determine if acute or regular (chronic) HIE performed before bedtime disrupts nighttime sleep of healthy adult, good sleepers compared with a no-exerci ...

Article GUID: 34416428


A multiobjective model for the green capacitated location-routing problem considering drivers' satisfaction and time window with uncertain demand

Author(s): Alamatsaz K; Ahmadi A; Mirzapour Al-E-Hashem SMJ;

Location-routing problem is a combination of facility location problem and vehicle routing problem. Numerous logistics problems have been extended to investigate greenhouse issues and costs related to the environmental impact of transportation activities. The green capacitated locating-routing problem (LRP) seeks to find the best places to establish facil ...

Article GUID: 34415526


Modeling of Flame Retardants in Typical Urban Indoor Environments in China during 2010-2030: Influence of Policy and Decoration and Implications for Human Exposure

Author(s): Li Z; Zhu Y; Wang D; Zhang X; Jones KC; Ma J; Wang P; Yang R; Li Y; Pei Z; Zhang Q; Jiang G;

Novel flame retardants (FRs) are of increasing concern, given growing evidence of health effects and use to replace polybrominated diphenyl ethers (PBDEs). This study modeled combined effects of use policies and decoration on indoor FRs and human exposure for 18 widely used PBDEs, organophosphate ...

Article GUID: 34410710


Public perceptions and behavioural responses to the first COVID-19 pandemic wave in Italy: Results from the iCARE study

Author(s): Stojanovic J; Raparelli V; Boccia S; Bacon SL; Lavoie KL;

Background: Italy was the first European country to be affected by COVID-19. Considering that many countries are currently battling the 2nd wave of the pandemic, understanding people's perceptions and responses to government policies remains critical for informing on-going mitigation strategies. We assessed attitudes towards COVID-19 policies, levels ...

Article GUID: 34406384


Seeing is believing: tools to study the role of Rho GTPases during cytokinesis

Author(s): Koh SP; Pham NP; Piekny A;

Cytokinesis is required to cleave the daughter cells at the end of mitosis and relies on the spatiotemporal control of RhoA GTPase. Cytokinesis failure can lead to changes in cell fate or aneuploidy, which can be detrimental during development and/or can lead to cancer. However, our knowledge of the pathways that regulate RhoA during cytokinesis is limite ...

Article GUID: 34405757


Reductions of Anxiety Symptoms, State Anxiety, and Anxious Arousal in Youth Playing the Videogame MindLight Compared to Online Cognitive Behavioral Therapy

Author(s): Tsui TYL; DeFrance K; Khalid-Khan S; Granic I; Hollenstein T;

i>Objective: Anxiety disorders are the most prevalent form of psychopathology among youth. Because demand for treatment far exceeds availability, there is a need for alternative approaches that are accessible, engaging, and incorporate practice to reach as many youth as possible. MindLight is a novel videogame intervention that combines evidence-based anx ...

Article GUID: 34403591


G protein-coupled estrogen receptor-1 enhances excitatory synaptic responses in the entorhinal cortex

Author(s): Batallán Burrowes AA; Sundarakrishnan A; Bouhour C; Chapman CA;

Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory and associational input to the hippocampus, but it is unclear whether either estrogens or progestogens ...

Article GUID: 34399010


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