Author(s): Pellegrino G; Hedrich T; Sziklas V; Lina JM; Grova C; Kobayashi E;

Interactions between interictal epileptiform discharges (IEDs) and distant cortical regions subserve potential effects on cognition of patients with focal epilepsy. We hypothesize that "healthy" brain areas at a distance from the epileptic focus may respond to the interference of IEDs by generating inhibitory alpha and beta oscillations. We predict that m ...

Article GUID: 34002916

Author(s): Lentini M; Scalia J; Lebel FB; Touma F; Jhajj A; Darlington PJ; Dover G;

Context: Athletes are often exposed to pain due to injury and competition. Using preliminary evidence, researchers have shown that cardiovascular measures could be an objective measure of pain, but the cardiovascular response can be influenced by psychological factors, such as catastrophizing. Objective: To use a painful cold-pressor test (CPT) to measur ...

Article GUID: 34000018

Author(s): Bhandari PM; Levis B; Neupane D; Patten SB; Shrier I; Thombs BD; Benedetti A;

Objective: To evaluate, across multiple sample sizes, the degree that data-driven methods result in (1) optimal cutoffs different from population optimal cutoff and (2) bias in accuracy estimates. Study design and setting: A total of 1,000 samples of sample size 100, 200, 500 and 1,000 each were randomly drawn to simulate studies of different sample size ...

Article GUID: 33838273

Author(s): Edache IY; Kakinami L; Alberga AS;

Objectives: Public health policies have been proposed to help address prevalent Canadian obesity rates. Along with the increase in obesity prevalence, explicit weight bias is also rampant in Western society. This paper aimed to assess the association between explicit weight bias attitudes and Canadian public support of these policy recommendations. Metho ...

Article GUID: 33990876

Author(s): Turner L; Santosa S;

With increasing adiposity in obesity, adipose tissue macrophages contribute to adipose tissue malfunction and increased circulating proinflammatory cytokines. The chronic low-grade inflammation that occurs in obesity ultimately gives rise to a state of metainflammation that increases the risk of metabolic disease. To date, only lifestyle and surgical inte ...

Article GUID: 33979430

Author(s): Selvaraj G; Kaliamurthi S; Peslherbe GH; Wei DQ;

ackground: Coronavirus (CoV) is an emerging human pathogen causing severe acute respiratory syndrome (SARS) around the world. Earlier identification of biomarkers for SARS can facilitate detection and reduce the mortality rate of the disease. Thus, by integrated network analysis and structural modeling approach, we aimed to explore the potential drug targ ...

Article GUID: 33968364

Author(s): Tremblay SA; Jäger AT; Huck J; Giacosa C; Beram S; Schneider U; Grahl S; Villringer A; Tardif CL; Bazin PL; Steele CJ; Gauthier CJ;

Efficient neural transmission is crucial for optimal brain function, yet the plastic potential of white matter (WM) has long been overlooked. Growing evidence now shows that modifications to axons and myelin occur not only as a result of long-term learning, but also after short training periods. ...

Article GUID: 33885965

Author(s): Costa ACBP; Omran RP; Law C; Dumeaux V; Whiteway M;

Candida albicans opaque cells release pheromones to stimulate cells of opposite mating type to activate their pheromone response pathway. Although this fungal pathogen shares orthologous proteins involved in the process with Saccharomyces cerevisiae, the pathway in each organism has unique characteristics. We have used GFP-tagged fusion proteins to invest ...

Article GUID: 33793759

Author(s): Pothier K; Vrinceanu T; Intzandt B; Bosquet L; Karelis AD; Lussier M; Vu TTM; Nigam A; Li KZH; Berryman N; Bherer L;

Objectives: Mobility is a complex but crucial clinical outcome in older adults. Past observational studies have highlighted that cardiorespiratory fitness (CRF), energy cost of walking (ECW), and cognitive switching abilities are associated with mobility performance, making these key determinants ...

Article GUID: 33774144

Author(s): Machado A; Cai Z; Vincent T; Pellegrino G; Lina JM; Kobayashi E; Grova C;

In functional near infrared spectroscopy (fNIRS), deconvolution analysis of oxy and deoxy-hemoglobin concentration changes allows estimating specific hemodynamic response functions (HRF) elicited by neuronal activity, taking advantage of the fNIRS excellent temporal resolution. Diffuse optical tomography (DOT) is also becoming the new standard reconstruct ...

Article GUID: 33727581

Author(s): Masoumi N; Belasso CJ; Ahmad MO; Benali H; Xiao Y; Rivaz H;

Purpose: Accurate multimodal registration of intraoperative ultrasound (US) and preoperative computed tomography (CT) is a challenging problem. Construction of public datasets of US and CT images can accelerate the development of such image registration techniques. This can help ensure the accuracy and safety of spinal surgeries using image-guided surgery ...

Article GUID: 33683544

Author(s): Zhang X; Wasson MC; Shayan M; Berdichevsky EK; Ricardo-Noordberg J; Singh Z; Papazyan EK; Castro AJ; Marino P; Ajoyan Z; Chen Z; Islamoglu T; Howarth AJ; Liu Y; Majewski MB; Katz MJ; Mondloch JE; Farha OK;

Porphyrins are important molecules widely found in nature in the form of enzyme active sites and visible light absorption units. Recent interest in using these functional molecules as building blocks for the construction of metal-organic frameworks (MOFs) have rapidly increased due to the ease in ...

Article GUID: 33678810