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Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Author(s): Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y;

Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it. Consequently, converting FLC into a fungicidal agent using adjuvants assumes significance to circumvent FLC resistance and the perpetua ...

Article GUID: 38929106


Modelling reindeer rut activity using on-animal acoustic recorders and machine learning

Author(s): Boucher AJ; Weladji RB; Holand Ø; Kumpula J;

For decades, researchers have employed sound to study the biology of wildlife, with the aim to better understand their ecology and behaviour. By utilizing on-animal recorders to capture audio from freely moving animals, scientists can decipher the vocalizations and glean insights into their behaviour and ecosystem dynamics through advanced signal processi ...

Article GUID: 38932958


Molecular copper(I)-sensitized photoanodes for alcohol oxidation under ambient conditions

Author(s): Ricardo-Noordberg J; Kamal S; Majewski M;

Dye-sensitized photoelectrochemical cells can enable the production of molecules currently accessible through energetically demanding syntheses. Copper(I)-based dyes represent electronically tunable charge transfer and separation systems. Herein, we report a Cu(I)-bisdiimine donor-chromophore-acceptor dye with an absorbance in the visible part of the sola ...

Article GUID: 38932662


Evaluating Sustainable Practices for Managing Residue Derived from Wheat Straw

Author(s): Shanmugam H; Raghavan V; Rajagopal R; Goyette B; Lyu L; Zhou S; An C;

Farm leftovers, particularly crop residues, are a key source of renewable energy in Canada. The nation's robust agricultural industry provides ample biomass, derived from forestry and agriculture resources, for energy generation. Crop residues, such as straws and husks, play a crucial role in this biomass reservoir, contributing to biofuel production ...

Article GUID: 38927790


Advancements in Heavy Metal Stabilization: A Comparative Study on Zinc Immobilization in Glass-Portland Cement Binders

Author(s): Bouchikhi A; Safhi AEM; Maherzi W; Mamindy-Pajany Y; Kunther W; Benzerzour M; Abriak NE;

Recent literature has exhibited a growing interest in the utilization of ground glass powder (GP) as a supplementary cementitious material (SCM). Yet, the application of SCMs in stabilizing heavy metallic and metalloid elements remains underexplored. This research zeroes in on zinc stabilization using a binder amalgam of GP and ordinary Portland cement (O ...

Article GUID: 38930239


Electroforming of Personalized Multi-Level and Free-Form Metal Parts Utilizing Fused Deposition Modeling-Manufactured Molds

Author(s): Hamed H; Aghili S; Wüthrich R; Abou-Ziki JD;

Adapting to the growing demand for personalized, small-batch manufacturing, this study explores the development of additively manufactured molds for electroforming personalized metal parts. The approach integrates novel multi-level mold design and fabrication techniques, along with the experimental procedures for the electroforming process. This work outl ...

Article GUID: 38930706


Comparing the Drop Vertical Jump Tracking Performance of the Azure Kinect to the Kinect V2

Author(s): Abdelnour P; Zhao KY; Babouras A; Corban JPAH; Karatzas N; Fevens T; Martineau PA;

Traditional motion analysis systems are impractical for widespread screening of non-contact anterior cruciate ligament (ACL) injury risk. The Kinect V2 has been identified as a portable and reliable alternative but was replaced by the Azure Kinect. We hypothesize that the Azure Kinect will assess drop vertical jump (DVJ) parameters associated with ACL inj ...

Article GUID: 38931598


A genome catalogue of mercury-methylating bacteria and archaea from sediments of a boreal river facing human disturbances

Author(s): Lawruk-Desjardins C; Storck V; Ponton DE; Amyot M; Walsh DA;

Methyl mercury, a toxic compound, is produced by anaerobic microbes and magnifies in aquatic food webs, affecting the health of animals and humans. The exploration of mercury methylators based on genomes is still limited, especially in the context of river ecosystems. To address this knowledge gap, we developed a genome catalogue of potential mercury-meth ...

Article GUID: 38922750


Associations between valenced news and affect in daily life: Experimental and ecological momentary assessment approaches

Author(s): Shaikh SJ; McGowan AL; Lydon-Staley DM;

In 203 (mean age = 38.04 years, SD=12.05) participants, we tested the association between valenced news and affect using a 14-day, smartphone-based ecological momentary assessment protocol consisting of two components: 1) a once-per-day experimental protocol in which participants were exposed to good news and bad news stories and 2) a four-times-per-day p ...

Article GUID: 38919709


Registered report: Age-preserved semantic memory and the CRUNCH effect manifested as differential semantic control networks: An fMRI study

Author(s): Haitas N; Dubuc J; Massé-Leblanc C; Chamberland V; Amiri M; Glatard T; Wilson M; Joanette Y; Steffener J;

Semantic memory representations are generally well maintained in aging, whereas semantic control is thought to be more affected. To explain this phenomenon, this study tested the predictions of the Compensation-Related Utilization of Neural Circuits Hypothesis (CRUNCH), focusing on task demands i ...

Article GUID: 38917084


Fabrication of thermo-responsive multicore microcapsules using a facile extrusion process

Author(s): Lavertu JD; Bawa KK; Hrapovic S; Fu D; Oh JK; Hemraz UD;

A process employing extrusion was used to produce multicore microcapsules composed of multiple beads. The inner beads were made from ?-carrageenan (?-c), a thermo-responsive linear sulphated polymer whose gelling temperature ranges at 40-60 °C, depending on the concentration of ?-c polymer and the amount of potassium chloride used for gelation. The result ...

Article GUID: 38915334


The impact of cognitive-motor interference on balance and gait in hearing-impaired older adults: a systematic review

Author(s): Wunderlich A; Wollesen B; Asamoah J; Delbaere K; Li K;

Background: Hearing impairments are a rising burden in our aging society. Hearing loss is associated with reduced cognitive performance as well as decrements in balance and gait. Therefore, impaired hearing affects also dual tasking (DT). The aim of this review is to summarize the evidence for DT performance decrements of older adults with hearing impairm ...

Article GUID: 38914940


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