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A case study in developmental discontinuity: PROSPER Interventions and adolescent substance use trajectories shape young adult substance use and mental health problems

Author(s): Fosco GM; Fang S; Chen L; Feinberg ME; Spoth R;

The loss of John Schulenberg reverberates across the developmental and prevention sciences. In honor of his many contributions, this paper applies his ideas of developmental continuity and discontinuity to understand the process by which PROSPER delivered universal prevention programs (delivered in Grades 6 and 7) affect young adult outcomes. Guided by th ...

Article GUID: 38595030


Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM; Ryan S; Raphael S; van Faassen H; Zafer A; Zhu Q; Maclean S; Chattopadhyay A; Gurnani K; Gilber ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains common. Camelid single-domain antibodies (sdAbs or nanobodies) are smaller, simpler, and easier to reco ...

Article GUID: 38596311


Understanding Adolescents' Experiences With Menstrual Pain to Inform the User-Centered Design of a Mindfulness-Based App: Mixed Methods Investigation Study

Author(s): Gagnon MM; Brilz AR; Alberts NM; Gordon JL; Risling TL; Stinson JN;

Background: Digital interventions are increasingly popular for the provision of nonpharmacological pain interventions, but few exist for adolescents with menstrual pain. User-centered design involves incorporating users across phases of digital health intervention design, development, and implementation and leads to improved user engagement and outcomes. ...

Article GUID: 38587886


Interactive effects of alcohol and cannabis quantities in the prediction of same-day negative consequences among young adults

Author(s): Wardell JD; Coelho SG; Farrelly KN; Fox N; Cunningham JA; O' Connor RM; Hendershot CS;

Background: Simultaneous alcohol and cannabis use is common, but observational studies examining negative consequences of simultaneous use have rarely considered dose-related interactions between alcohol and cannabis. This study examined interactions between quantities of cannabis and alcohol con ...

Article GUID: 38575530


Digitizing natureGaia's Web Karen Bakker MIT Press, 2024. 288 pp

Author(s): Garard J; Matthews HD;

Digital tools are transforming conservation work but must be carefully deployed, argues an environmental scholar.

Article GUID: 38574131


In Silico Study of the Early Stages of Aggregation of β-Sheet Forming Antimicrobial Peptide GL13K

Author(s): Hamidabad MN; Watson NA; Wright LN; Mansbach RA;

Antimicrobial peptides (AMPs) are of growing interest as potential candidates that may offer more resilience against antimicrobial resistance than traditional antibiotic agents. In this article, we perform the first in silico study of the synthetic ß sheet-forming AMP GL13K. Through atomistic simulations of single and multi-peptide systems under different ...

Article GUID: 38572930


Spatial versus spatio-temporal approaches for studying metacommunities: a multi-taxon analysis in Mediterranean and tropical temporary ponds

Author(s): Gálvez Á; Peres-Neto PR; Castillo-Escrivà A; Bonilla F; Camacho A; García-Roger EM; Iepure S; Miralles J; Monrós JS; Olmo C; Picazo A; Rojo C; Rueda J; Sasa M; Segura M; Armengol X; Mesquita-Joanes F;

Prior research on metacommunities has largely focused on snapshot surveys, often overlooking temporal dynamics. In this study, our aim was to compare the insights obtained from metacommunity analyses based on a spatial approach repeated over time, with a spatio-temporal approach that consolidates ...

Article GUID: 38565154


The interpersonal benefits of goal adjustment capacities: the sample case of coping with poor sleep in couples

Author(s): Meaghan A Barlow

INTRODUCTION: This study examined the role of goal adjustment capacities and coping in the association between spousal sleep efficiency and relationship satisfaction in romantic couples.

Article GUID: 38566936


A multidimensional investigation of sleep and biopsychosocialprofiles with associated neural signatures

Author(s): Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Thomas Yeo BT;

Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to ident ...

Article GUID: 38559143


From Compliance to Care: Qualitative Findings from a Survey of Essential Caregivers in Ontario Long-Term Care Homes

Author(s): Conklin J; Dehcheshmeh MM; Archibald D; Elliott J; Hsu A; Kothari A; Stolee P; Sveistrup H;

Background: The COVID-19 pandemic highlighted the importance of the care provided by family members and close friends to older people living in long-term care (LTC) homes. Our implementation science team helped three Ontario LTC homes to implement an intervention to allow family members to enter ...

Article GUID: 38561989


Mechanical Control of Quantum Transport in Graphene

Author(s): McRae AC; Wei G; Huang L; Yigen S; Tayari V; Champagne AR;

2D materials (2DMs) are fundamentally electro-mechanical systems. Their environment unavoidably strains them and modifies their quantum transport properties. For instance, a simple uniaxial strain can completely turn off the conductance of ballistic graphene or switch on/off the superconducting phase of magic-angle bilayer graphene. This article reports m ...

Article GUID: 38558481


Ultra-thin flexible rectenna integrated with power management unit for wireless power harvester/charging of smartwatch/wristband

Author(s): Singh N; Khan T; Kumar S; Kanaujia BK; Choi HC; Kim KW; Rambabu K; Rengarajan SR; Kishk AA;

This paper proposes a circularly polarized ultra-thin flexible antenna with a flexible rectifier and power management unit (PMU) for smartwatch/wristband applications. The flexible antenna is compact (0.17?0 × 0.20?0 × 0.0004?0) and has a stepped ground plane. A parasitic element is used at the s ...

Article GUID: 38548782


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