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Intrinsic structural covariation links cerebellum subregions to the cerebral cortex

Author(s): Wang Z; Diedrichsen J; Saltoun K; Steele C; Arnold-Anteraper SR; Yeo BTT; Schmahmann JD; Bzdok D;

The human cerebellum is increasingly recognized to be involved in non-motor and higher-order cognitive functions. Yet, its ties with the entire cerebral cortex have not been holistically studied in a whole-brain exploration with a unified analytical framework. Here, we characterized dissociable c ...

Article GUID: 39052236


Education in Laparoscopic Cholecystectomy: Design and Feasibility Study of the LapBot Safe Chole Mobile Game

Author(s): Noroozi M; St John A; Masino C; Laplante S; Hunter J; Brudno M; Madani A; Kersten-Oertel M;

Background: Major bile duct injuries during laparoscopic cholecystectomy (LC), often stemming from errors in surgical judgment and visual misperception of critical anatomy, significantly impact morbidity, mortality, disability, and health care costs. Objective: To enhance safe LC learning, we de ...

Article GUID: 39052314


A Survey on Error Exponents in Distributed Hypothesis Testing: Connections with Information Theory, Interpretations, and Applications

Author(s): Espinosa S; Silva JF; Céspedes S;

A central challenge in hypothesis testing (HT) lies in determining the optimal balance between Type I (false positive) and Type II (non-detection or false negative) error probabilities. Analyzing these errors' exponential rate of convergence, known as error exponents, provides crucial insights into system performance. Error exponents offer a lens thro ...

Article GUID: 39056958


Open access segmentations of intraoperative brain tumor ultrasound images

Author(s): Behboodi B; Carton FX; Chabanas M; de Ribaupierre S; Solheim O; Munkvold BKR; Rivaz H; Xiao Y; Reinertsen I;

Purpose: Registration and segmentation of magnetic resonance (MR) and ultrasound (US) images could play an essential role in surgical planning and resectioning brain tumors. However, validating these techniques is challenging due to the scarcity of publicly accessible sources with high-quality gr ...

Article GUID: 39047165


Age of obesity onset affects subcutaneous adipose tissue cellularity differently in the abdominal and femoral region

Author(s): Murphy J; Dera A; Morais JA; Tsoukas MA; Khor N; Sazonova T; Almeida LG; Cooke AB; Daskalopoulou SS; Tam BT; Santosa S;

Objective: We aimed to examine the effect of age of obesity onset, sex, and their interaction on abdominal and femoral subcutaneous adipose tissue (SAT) morphology (degree of adipocyte hyperplasia or hypertrophy). Methods: In this cross-sectional study, we isolated adipocytes via collagenase dig ...

Article GUID: 39045668


Evidence of isochorismate channeling between the Escherichia coli enterobactin biosynthetic enzymes EntC and EntB

Author(s): Bin X; Pawelek PD;

Enterobactin is a high-affinity iron chelator produced and secreted by Escherichia coli and Salmonella typhimurium to scavenge scarce extracellular Fe3+ as a micronutrient. EntC and EntB are the first two enzymes in the enterobactin biosynthetic pathway. Isochorismate, produced by EntC, is a substrate for EntB isochorismatase. By using a competing isochor ...

Article GUID: 39031458


Revealing the Freezing-Induced Alteration in Microplastic Behavior and Its Implication for the Microplastics Released from Seasonal Ice

Author(s): Chen Z; Elektorowicz M; An C; Tian X; Wang Z; Yang X; Lyu L;

Ice can serve as a significant temporary repository and conveyance mechanism for microplastics (MPs). MPs present in the water column can become entrapped within developing ice formations, subsequently being sequestered and transported by ice floes. With changing temperatures, MPs stored in ice can be released back into the environment, while freezing con ...

Article GUID: 39031076


A unified stochastic SIR model driven by Lévy noise with time-dependency

Author(s): Easlick T; Sun W;

We propose a unified stochastic SIR model driven by Lévy noise. The model is structural enough to allow for time-dependency, nonlinearity, discontinuity, demography, and environmental disturbances. We present concise results on the existence and uniqueness of positive global solutions and investigate the extinction and persistence of the novel model. Exam ...

Article GUID: 39027117


NREM sleep brain networks modulate cognitive recovery from sleep deprivation

Author(s): Lee K; Wang Y; Cross NE; Jegou A; Razavipour F; Pomares FB; Perrault AA; Nguyen A; Aydin Ü; Uji M; Abdallah C; Anticevic A; Frauscher B; Benali H; Dang-Vu TT; Grova C;

Decrease in cognitive performance after sleep deprivation followed by recovery after sleep suggests its key role, and especially non-rapid eye movement (NREM) sleep, in the maintenance of cognition. It remains unknown whether brain network reorganization in NREM sleep stages N2 and N3 can uniquel ...

Article GUID: 39005401


Co-regulation, relationship quality, and infant distress vocalizations observed during mother-infant interactions: Influences of maternal depression and different contexts

Author(s): Leong EL; Stack DM; Lazimbat OK; Bouchard S; Field TM;

Mother-infant interactions are co-regulated and provide the foundation for mother-infant relationship quality. The implications of maternal depression and contextual demands (i.e., reinstating the interaction following maternal unavailability and vocalized infant distress) on observationally coded co-regulation in mother-infant dyads (n = 40) at 4-months ...

Article GUID: 39024126


Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells

Author(s): Bagheri H; Friedman H; Hadwen A; Jarweh C; Cooper E; Oprea L; Guerrier C; Khadra A; Collin A; Cohen-Adad J; Young A; Victoriano GM; Swire M; Jarjour A; Bechler ME; Pryce RS; Chaurand P; Cougnaud L; Vuckovic D; Wilion E; Greene O; Nishiya ...

Myelin basic protein (Mbp) is essential for both elaboration and maintenance of CNS myelin, and its reduced accumulation results in hypomyelination. How different Mbp mRNA levels affect myelin dimensions across the lifespan and how resident glial cells may respond to such changes are unknown. Her ...

Article GUID: 39023138


Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1

Author(s): Kozlov G; Jiang J; Rutherford T; Noronha AM; Wilds CJ; Gehring K;

La-related proteins (LARPs) are a family of RNA-binding proteins that share a conserved La motif (LaM) domain. LARP1 plays a role in regulating ribosomal protein synthesis and stabilizing mRNAs and has a unique structure without an RNA binding RRM domain adjoining the LaM domain. In this study, we investigated the physical basis for LARP1 specificity for ...

Article GUID: 39016322


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