Author(s): Li W; Whiteway M; Hang S; Yu J; Lu H; Jiang Y;

Azole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 and L238 of Erg11 are critical for its interaction with Ncp1, and the Ncp1-Erg11 association is important in azole respo ...

Article GUID: 40707518

Author(s): Marrett JM; Effaty F; Ottenwaelder X; Frišcic T;

The mechanochemistry of metal-organic frameworks (MOFs) is a well-established field whose development has advanced the understanding and the design of both MOF materials and mechanochemical reactions. This review outlines the close and mutually beneficial interplay of these two fields over the past two decades, including the description of mechanochemical ...

Article GUID: 40708349

Author(s): Carter F; Anwander A; Johnson M; Goucha T; Adamson H; Friederici AD; Lutti A; Gauthier CJ; Weiskopf N; Bazin PL; Steele CJ;

The study of brain structure and change in neuroscience is commonly conducted using macroscopic morphological measures of the brain such as regional volume or cortical thickness, providing little insight into the microstructure and physiology of the brain. In contrast, quantitative Magnetic Reson ...

Article GUID: 40705745

Author(s): Garner RE; Taranu ZE; Higgins SN; Paterson MJ; Gregory-Eaves I; Walsh DA;

Lake ecosystems are increasingly impacted by eutrophication and climate change. Whole-lake experiments have provided ecosystem-scale insights into the effects of freshwater stressors, yet these are constrained to the duration of monitoring programmes. Here, we leveraged multidecadal monitoring records and century-scale paleogenetic reconstructions for exp ...

Article GUID: 40704779

Author(s): Stark Z; Johnson AP;

Dyslexia is a neurobiological disorder characterized by persistent difficulties in reading, writing and spelling. Studying adults with dyslexia is challenging due to diverse experiences, varying ages of diagnosis and potential comorbidities. This study utilized a mixed-method approach to explore how the timing and occurrence of a dyslexia diagnosis influe ...

Article GUID: 40702374

Author(s): Alberts NM; Stratton KL; Leisenring WM; Pizzo A; Lamoureux É; Alschuler K; Flynn J; Krull KR; Jibb LA; Nathan PC; Olgin JE; Stinson JN; Armstrong GT;

Purpose: Intolerance of uncertainty is central to many psychological disorders and may contribute to pain. Despite the uncertainty inherent in childhood cancer survivorship, little is known about intolerance of uncertainty in this population. This study aimed to characterize intolerance of uncert ...

Article GUID: 40699439

Author(s): Robinson TD; Sun YL; Chang PTH; Gauthier CJ; Chen JJ;

One of the most promising interventional targets for brain health is cerebral perfusion, but its link to white matter (WM) aging remains unclear. Motivated by existing literature demonstrating links between declining cortical perfusion and the development of WM hyperintensities, we posit that regional WM hypoperfusion precedes deteriorating WM integrity. ...

Article GUID: 40694306

Author(s): Balbim GM; Boa Sorte Silva NC; Falck RS; Kramer AF; Voss MW; Liu-Ambrose T;

Introduction: The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume. Methods: Cross-sectional study in ...

Article GUID: 40693459

Author(s): Md Shike Bin Mazid Anik

Urban flooding has become a growing concern for many cities due to accelerating urbanisation, changing weather, and drainage system aging. Earlier studies of floods have taken primarily the traditional process-based approach to predicting urban floods, offering limited exploration of recent advancements in AI-driven, real-time, and community-integrated ap ...

Article GUID: 40692624

Author(s): Deng Z; Perry JM; Weiss M; Genth R; Autour A; Merten CA; Shih SCC;

Droplet microfluidics has become a ubiquitous and powerful tool for high-throughput phenotypic screening at the single-cell level. Large numbers of cells can be sorted for a variety of functions, including the secretion of antibodies with tailored properties. The recovery of cells from sorted droplets is still very poor compared to droplet sorting, usuall ...

Article GUID: 40693295

Author(s): Mirzahosseini Z; Shabani L; Sabzalian MR; Shojaiefar S; Dayanandan S;

In this study, a comparative proteomic analysis was conducted on four agriculturally important genotypes of fennel (Foeniculum vulgare Mill.) named Yazd, Tabriz, Varamin, and Karaj to identify effective proteins and mechanisms involved in self-incompatibility. Self-pollinated and open-pollinated seeds from each genotype were planted in separate lines. The ...

Article GUID: 40691524

Author(s): Begum A; Uddin MA; Ahsan SM; Islam MA;

Background and aims: The rapid development and deployment of COVID-19 vaccines have been pivotal in the global battle against the pandemic. However, vaccine acceptance remains a critical determinant of their effectiveness. While numerous studies have explored factors influencing vaccine acceptance, there is a notable dearth of research regarding preferenc ...

Article GUID: 40687549