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PILLAR: ParaspInaL muscLe segmentAtion pRoject - a comprehensive online resource to guide manual segmentation of paraspinal muscles from magnetic resonance imaging

Author(s): Anstruther M; Rossini B; Zhang T; Liang T; Xiao Y; Fortin M;

Background: There is an increasing interest in assessing paraspinal morphology and composition in relation to low back pain (LBP). However, variations in methods and segmentation protocols contribute to the inconsistent findings in the literature. We present an on-line resource, the ParaspInaL muscLe segmentAtion pRoject (PILLAR, https://projectpillar.git ...

Article GUID: 37996857


Frontoparietal functional connectivity moderates the link between time spent on social media and subsequent negative affect in daily life

Author(s): Kang Y; Ahn J; Cosme D; Mwilambwe-Tshilobo L; McGowan A; Zhou D; Boyd ZM; Jovanova M; Stanoi O; Mucha PJ; Ochsner KN; Bassett DS; Lydon-Staley D; Falk EB;

Evidence on the harms and benefits of social media use is mixed, in part because the effects of social media on well-being depend on a variety of individual difference moderators. Here, we explored potential neural moderators of the link between time spent on social media and subsequent negative ...

Article GUID: 37993522


Audiovisual integration in children with cochlear implants revealed through EEG and fNIRS

Author(s): Alemi R; Wolfe J; Neumann S; Manning J; Towler W; Koirala N; Gracco VL; Deroche M;

Sensory deprivation can offset the balance of audio versus visual information in multimodal processing. Such a phenomenon could persist for children born deaf, even after they receive cochlear implants (CIs), and could potentially explain why one modality is given priority over the other. Here, we recorded cortical responses to a single speaker uttering t ...

Article GUID: 37989460


A qualitative exploration on the needs of health care providers working with adolescents who are undergoing bariatric surgery

Author(s): Farnesi BC; Kaffash K; Cohen TR; Alberga AS;

Background: With increasing prevalence of severe obesity in youth, more adolescents are becoming candidates for bariatric surgery. In Canada, bariatric surgery in adolescents is in its infancy, and long-term health outcomes are not well known. It is unknown what health care providers (HCPs) are using to prepare and guide their adolescent patients for bari ...

Article GUID: 37990654


Motor Processing in Children With Cochlear Implants as Assessed by Functional Near-Infrared Spectroscopy

Author(s): Alemi R; Wolfe J; Neumann S; Manning J; Hanna L; Towler W; Wilson C; Bien A; Miller S; Schafer E; Gemignani J; Koirala N; Gracco VL; Deroche M;

Auditory-motor and visual-motor networks are often coupled in daily activities, such as when listening to music and dancing; but these networks are known to be highly malleable as a function of sensory input. Thus, congenital deafness may modify neural activities within the connections between th ...

Article GUID: 37977135


Effects of cabergoline and dimethylcabergoline on the sexual behavior of male rats

Author(s): Pfaus JG; Antonie RA; Dosa PI; Kim SW;

Rationale: Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the release of prolactin through agonist actions on dopamine (DA) D2 receptors; however, it possesses binding affinity for other DA and 5-HT receptors. Side effects that exacerbate valvular heart disease can occur with high doses ...

Article GUID: 37968530


What is Learned Determines How Pavlovian Conditioned Fear is Consolidated in the Brain

Author(s): Leake J; Leidl DM; Lay BPP; Fam JP; Giles MC; Qureshi OA; Westbrook RF; Holmes NM;

Activity in the basolateral amygdala complex (BLA) is needed to encode fears acquired through contact with both innate sources of danger (i.e., things that are painful) and learned sources of danger (e.g., being threatened with a gun). However, within the BLA, the molecular processes required to consolidate the two types of fear are not the same: protein ...

Article GUID: 37963767


Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption

Author(s): Yang JG; Sun B; Wang Z; Li X; Gao JH; Qian JJ; Li J; Wei WJ; Zhang P; Wang W;

Osteoporosis has a profound influence on public health. First-line bisphosphonates often cause osteonecrosis of the jaw meanwhile inhibiting osteoclasts. Therefore, it is important to develop effective treatments. The results of this study showed that the increased level of NFATc1 m6A methylation caused by zoledronic acid (ZOL), with 4249A as the function ...

Article GUID: 37957146


Beliefs about losing control and other OCD-related cognitions: An experimental investigation

Author(s): Sandstrom A; Radomsky AS;

Background and objectives: Cognitive theories of obsessive-compulsive disorder (OCD) suggest that dysfunctional beliefs influence symptoms. However, well-established belief domains do not fully explain OCD symptomatology, suggesting other cognitive mechanisms may be involved. An additional belief domain which may play a role in OCD is beliefs about losing ...

Article GUID: 37948951


Metabolomics 2022 workshop report: state of QA/QC best practices in LC-MS-based untargeted metabolomics, informed through mQACC community engagement initiatives

Author(s): Dunn WB; Kuligowski J; Lewis M; Mosley JD; Schock T; Ulmer Holland C; Zanetti KA; Vuckovic D;

Introduction: The Metabolomics Quality Assurance and Quality Control Consortium (mQACC) organized a workshop during the Metabolomics 2022 conference. Objectives: The goal of the workshop was to disseminate recent findings from mQACC community-engagement efforts and to solicit feedback about a li ...

Article GUID: 37940740


Increased brain cholinergic innervation in isolated REM sleep behaviour disorder from prodromal multiple system atrophy

Author(s): Wickens RH; Postuma RB; de Villers-Sidani É; Pelletier A; Blinder S; Gagnon JF; Soucy JP; Montplaisir J; Bedard MA;

No abstract available

Article GUID: 37939636


Development and performance assessment of a new opensource Bayesian inference R platform for building energy model calibration

Author(s): Hou D; Zhan D; Wang L; Hassan IG; Sezer N;

Many factors contribute to the inherent uncertainty of energy consumption modeling in buildings. It is essential to perform a calibration and sensitivity analysis in order to manage these uncertainties. Despite the availability of several calibration methods, they are often deterministic and lack quantified uncertainties. Moreover, the selection of parame ...

Article GUID: 37936825


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