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School Experiences and Anxiety Trajectories Among Youth with Intellectual Disabilities

Author(s): Dubé C; Morin AJS; Olivier E; Gilbert W; Tracey D; Craven RG; Maïano C;

This study investigated how the school experiences and personal characteristics of youth with Intellectual Disabilities (ID) contribute to their longitudinal trajectories of anxiety. To this end, we relied on a sample of 390 youth with mild (48.2%) to moderate (51.8%) levels of ID, aged from 11 to 22 (M = 15.70), and recruited in Canada (n = 140) and Aust ...

Article GUID: 37898583


Heterogeneous dispersal networks to improve biodiversity science

Author(s): Savary P; Lessard JP; Peres-Neto PR;

Dispersal has a key role in shaping spatial patterns of biodiversity, yet its spatial heterogeneity is often overlooked in biodiversity analyses and management strategies. Properly parameterised heterogeneous dispersal networks capture the complex interplay between landscape structure and species-specific dispersal capacities. However, this heterogeneity ...

Article GUID: 37891075


Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

Author(s): Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT;

Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C. albicans can initiate a strong drug tolerance response that allows some cells to ...

Article GUID: 37888959


Winter's Topography, Law, and the Colonial Legal Imaginary in British Columbia

Author(s): Matthew P Unger

This article examines how images of nature, weather, and topography disclose a politics of recognition (who is visible/invisible) invested in a burgeoning criminal justice milieu, where punishment of wrongdoing became increasingly racialized in British Columbia during the early confederation period of Canada's history. Drawing from archived court docu ...

Article GUID: 37885918


The impact of COVID-19 on the lives of Canadians with and without non-communicable chronic diseases: results from the iCARE Study

Author(s): Deslauriers F; Gosselin-Boucher V; Léger C; Vieira AM; Bacon SL; Lavoie KL;

Background: The COVID-19 pandemic and its prevention policies have taken a toll on Canadians, and certain subgroups may have been disproportionately affected, including those with non-communicable diseases (NCDs; e.g., heart and lung disease) due to their risk of COVID-19 complications and women due to excess domestic workload associated with traditional ...

Article GUID: 37884921


Agreement between youth and caregiver report of pain and functioning in pediatric sickle cell disease: PedsQL sickle cell disease module

Author(s): Alberts NM; Gilbert A; Kang G; Okhomina VI; Flynn JS; Hodges J; Hankins JS; Klosky JL;

Pain is a primary symptom of sickle cell disease (SCD) and is often severe and chronic. To treat SCD-related pain, proper assessment of SCD pain among youth, including the degree of concordance or agreement between youth and caregiver reports of pain, is essential but has not yet been adequately evaluated. In this study, 525 youth with SCD and their paren ...

Article GUID: 37878652


Olfaction and reaction: The role of olfactory and hypothalamic investment in the antipredator responses to chemical alarm cues by northern redbelly dace

Author(s): Joyce BJ; Brown GE;

Neuroplasticity enables teleosts to promote or downregulate the growth of their brains regionally. To compensate for the effects of predation pressure, teleosts may alter their brain morphology and behavioral responses to mitigate its impact on individual fitness. High-predation environments often promote specific patterns of brain growth and produce bold ...

Article GUID: 37876646


Dosimetry of [18F]TRACK, the first PET tracer for imaging of TrkB/C receptors in humans

Author(s): Thiel A; Kostikov A; Ahn H; Daoud Y; Soucy JP; Blinder S; Jaworski C; Wängler C; Wängler B; Juengling F; Enger SA; Schirrmacher R;

Background: Reduced expression or impaired signalling of tropomyosin receptor kinases (Trk receptors) are found in a vast spectrum of CNS disorders. [18F]TRACK is the first PET radioligand for TrkB/C with proven in vivo brain penetration and on-target specific signal. Here we report dosimetry dat ...

Article GUID: 37870640


At-home computerized executive-function training to improve cognition and mobility in normal-hearing adults and older hearing aid users: a multi-centre, single-blinded randomized controlled trial

Author(s): Downey R; Gagné N; Mohanathas N; Campos JL; Pichora-Fuller KM; Bherer L; Lussier M; Phillips NA; Wittich W; St-Onge N; Gagné JP; Li K;

Background: Hearing loss predicts cognitive decline and falls risk. It has been argued that degraded hearing makes listening effortful, causing competition for higher-level cognitive resources needed for secondary cognitive or motor tasks. Therefore, executive function training has the potential ...

Article GUID: 37864139


Lactate's behavioral switch in the brain: An in-silico model

Author(s): Soltanzadeh M; Blanchard S; Soucy JP; Benali H;

Emerging evidence emphasizes lactate's involvement in both physiological processes (energy metabolism, memory, etc.) and disease (traumatic brain injury, epilepsy, etc.). Furthermore, the usefulness of mathematical modeling in deciphering underlying dynamics of the brain to investigate lactate roles and mechanisms of action has been well established. ...

Article GUID: 37865309


Cervical muscle morphometry and composition demonstrate prognostic value in degenerative cervical myelopathy outcomes

Author(s): Naghdi N; Elliott JM; Weber MH; Fehlings MG; Fortin M;

Objectives: This study aimed to examine whether preoperative cervical muscle size, composition, and asymmetry from magnetic resonance imaging (MRI) can predict post-operative outcomes in patients with degenerative cervical myelopathy (DCM). Methods: A total of 171 patients with DCM were included. Relative total cross-sectional area (RCSA), functional CSA ...

Article GUID: 37745653


The effects of acute exercise and a nap on heart rate variability and memory in young sedentary adults

Author(s): Mograss M; Frimpong E; Vilcourt F; Chouchou F; Zvionow T; Dang-Vu TT;

Recent evidence suggests that the autonomic nervous system can contribute to memory consolidation during sleep. Whether fluctuations in cardiac autonomic activity during sleep following physical exercise contribute to the process of memory consolidation has not been studied. We assessed the effects of a non-rapid eye movement (NREM) nap following acute ex ...

Article GUID: 37855092


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