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ESOMIR: a curated database of biomarker genes and miRNAs associated with esophageal cancer

Author(s): Sindhoo A; Sipy S; Khan A; Selvaraj G; Alshammari A; Casida ME; Wei DQ;

'Esophageal cancer' (EC) is a highly aggressive and deadly complex disease. It comprises two types, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), with Barrett's esophagus (BE) being the only known precursor. Recent research has revealed that microRNAs (miRNAs) play a crucial role in the development, prognosis a ...

Article GUID: 37815872


The caleosin RD20/CLO3 regulates lateral root development in response to abscisic acid and regulates flowering time in conjunction with the caleosin CLO7

Author(s): Brunetti SC; Arseneault MKM; Gulick PJ;

The caleosins are encoded by multi-gene families in Arabidopsis thaliana and other plant species. This work investigates the role of two family members, RD20/CLO3 and CLO7, in flowering transition and in root development in response to ABA treatment. Gene expression of the caleosin RD20/CLO3 is induced by ABA in the root tissues and RD20/CLO3 has a negati ...

Article GUID: 37812854


Do preschoolers trust a competent robot pointer?

Author(s): Baumann AE; Goldman EJ; Cobos MM; Poulin-Dubois D;

How young children learn from different informants has been widely studied. However, most studies investigate how children learn verbally conveyed information. Furthermore, most studies investigate how children learn from humans. This study sought to investigate how 3-year-old children learn from, and come to trust, a competent robot versus an incompetent ...

Article GUID: 37804786


The impact of cultural identity, parental communication, and peer influence on substance use among Indigenous youth in Canada

Author(s): Reynolds A; Keough MT; Blacklock A; Tootoosis C; Whelan J; Bomfim E; Mushquash C; Wendt DC; O' Connor RM; Burack JA;

Heavy drinking and smoking have been found to be among the leading causes of morbidity and mortality within Indigenous youth in North America. The focus of this study was to examine the relative roles of cultural identity, parent-child communication about the harms of substance use (SU), and perc ...

Article GUID: 37796930


Putting things right: An experimental investigation of memory biases related to symmetry, ordering and arranging behaviour

Author(s): Radomsky AS; Ouellet-Courtois C; Golden E; Senn JM; Parrish CL;

Background and objectives: Research indicates the presence of both explicit and implicit memory biases for threat. However, empirical support for the presence of memory biases related to symmetry, ordering and arranging is lacking, despite the fact that many individuals report anxiety associated with their personal belongings being out of place. The aim o ...

Article GUID: 37793286


Improvements in cardiorespiratory fitness, muscle strength and body composition to modest weight loss are similar in those with adult- versus childhood-onset obesity

Author(s): Lucas Guimarães Almeida

Adults who have had obesity from childhood are at greater risk of obesity-related comorbidities compared to those who only develop obesity in adulthood. The main way of mitigating these risks in obesity is with weight loss, which has been shown to positively affect the cardiorespiratory fitness (CRF) and body composition of adults. However, it is unclear ...

Article GUID: 37794721


The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans

Author(s): Shrivastava M; Kouyoumdjian GS; Kirbizakis E; Ruiz D; Henry M; Vincent AT; Sellam A; Whiteway M;

Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans. We found that activation of the transcription factor C4_02500C_A (Adr1) conferred significant resistance against fluconazole. In Saccharomy ...

Article GUID: 37791798


Comparison of Radiologists and Deep Learning for US Grading of Hepatic Steatosis

Author(s): Vianna P; Calce SI; Boustros P; Larocque-Rigney C; Patry-Beaudoin L; Luo YH; Aslan E; Marinos J; Alamri TM; Vu KN; Murphy-Lavallée J; Billiard JS; Montagnon E; Li H; Kadoury S; Nguyen BN; Gauthier S; Therien B; Rish I; Belilovsky E; Wolf ...

Background Screening for nonalcoholic fatty liver disease (NAFLD) is suboptimal due to the subjective interpretation of US images. Purpose To evaluate the agreement and diagnostic performance of radiologists and a deep learning model in grading hepatic steatosis in NAFLD at US, with biopsy as the ...

Article GUID: 37787678


Hydroxyl radical production by abiotic oxidation of pyrite under estuarine conditions: The effects of aging, seawater anions and illumination

Author(s): Liu R; Dai Y; Feng Y; Sun S; Zhang X; An C; Zhao S;

Pyrite is widely distributed in estuarine sediments as an inexpensive natural Fenton-like reagent, however, the mechanism on the hydroxyl radical (HO·) production by pyrite under estuarine environmental conditions is still poorly understood. The batch experiments were performed to investigate the effects of estuarine conditions including aging (in air, in ...

Article GUID: 37778841


Interplay between male quality and male-female compatibility across episodes of sexual selection

Author(s): Mahdjoub H; Khelifa R; Roy J; Sbilordo SH; Zeender V; Perdigón Ferreira J; Gourgoulianni N; Lüpold S;

The processes underlying mate choice profoundly influence the dynamics of sexual selection and the evolution of male sexual traits. Consistent preference for certain phenotypes may erode genetic variation in populations through directional selection, whereas divergent preferences (e.g., genetical ...

Article GUID: 37774022


Advances in the design and use of carbon dots for analytical and biomedical applications

Author(s): Adeola AO; Clermont-Paquette A; Piekny A; Naccache R;

Carbon dots (CDs) have garnered significant interest for their potential use in multiple applications due to their size, fluorescent properties, high photostability, low toxicity and biocompatibility. CDs can be tailored for specific needs, as they can be synthesized with diverse precursors and techniques for functionalization. Since the applications of C ...

Article GUID: 37757783


Cavitation-Enhanced Drug Delivery and Immunotherapy

Author(s): Helfield B; Sirsi S; Kwan J; Gray M;

Welcome to this special issue on Cavitation-Enhanced Drug Delivery and Immunotherapy-a rapidly evolving area that has been buoyed in recent years by the development of methods harnessing the activity of ultrasound-stimulated bubbles known as cavitation [...].

Article GUID: 37765176


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