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Identification of a Conserved Transcriptional Activator-Repressor Module Controlling the Expression of Genes Involved in Tannic Acid Degradation and Gallic Acid Utilization in Aspergillus niger

Author(s): Arentshorst M; Falco MD; Moisan MC; Reid ID; Spaapen TOM; van Dam J; Demirci E; Powlowski J; Punt PJ; Tsang A; Ram AFJ;

Tannic acid, a hydrolysable gallotannin present in plant tissues, consists of a central glucose molecule esterified with gallic acid molecules. Some microorganisms, including several Aspergillus species, can metabolize tannic acid by releasing gallic acid residues from tannic acid by secreting ta ...

Article GUID: 37744122


Utilization of ferulic acid in Aspergillus niger requires the transcription factor FarA and a newly identified Far-like protein (FarD) that lacks the canonical Zn(II)2Cys6 domain

Author(s): Arentshorst M; Reijngoud J; van Tol DJC; Reid ID; Arendsen Y; Pel HJ; van Peij NNME; Visser J; Punt PJ; Tsang A; Ram AFJ;

The feruloyl esterase B gene (faeB) is specifically induced by hydroxycinnamic acids (e.g. ferulic acid, caffeic acid and coumaric acid) but the transcriptional regulation network involved in faeB induction and ferulic acid metabolism has only been partially addressed. To identify transcription f ...

Article GUID: 37746181


The gut microbiota and its biogeography

Author(s): McCallum G; Tropini C;

Biogeography is the study of species distribution and diversity within an ecosystem and is at the core of how we understand ecosystem dynamics and interactions at the macroscale. In gut microbial communities, a historical reliance on bulk sequencing to probe community composition and dynamics has overlooked critical processes whereby microscale interactio ...

Article GUID: 37740073


A multilevel mHealth intervention boosts adherence to hydroxyurea in individuals with sickle cell disease

Author(s): Hankins JS; Brambilla D; Potter MB; Kutlar A; Gibson RW; King AA; Baumann AA; Melvin CL; Gordeuk VR; Hsu LL; Nwosu C; Porter JS; Alberts NM; Badawy SM; Simon J; Glassberg J; Lottenberg R; DiMartino L; Jacobs S; Fernandez ME; Bosworth H; ...

Hydroxyurea reduces sickle cell disease (SCD) complications, but medication adherence is low. We tested two mobile health (mHealth) interventions targeting determinants of low adherence among patients (InCharge Health) and low prescribing among providers (HU Toolbox) in a multi-center non-randomi ...

Article GUID: 37738155


Measuring prion propagation in single bacteria elucidates a mechanism of loss

Author(s): Jager K; Orozco-Hidalgo MT; Springstein BL; Joly-Smith E; Papazotos F; McDonough E; Fleming E; McCallum G; Yuan AH; Hilfinger A; Hochschild A; Potvin-Trottier L;

Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathies in mammals, but prions can also constitute nontoxic protein-based elements of inheritance in fung ...

Article GUID: 37738299


An insight into the benefits of substituting polypropylene with biodegradable polylactic acid face masks for combating environmental emissions

Author(s): Lyu L; Peng H; An C; Sun H; Yang X; Bi H;

Mask waste can affect the natural environment and human health. In this study, the life cycle assessment (LCA) of two types of face masks (Polylactic acid (PLA) and Polypropylene (PP)) was first performed to evaluate the environmental impacts from production to end-of-life, and then, greenhouse gas (GHG) emissions were estimated for each life stage. The G ...

Article GUID: 37734618


Fitness Costs of Antibiotic Resistance Impede the Evolution of Resistance to Other Antibiotics

Author(s): Chowdhury FR; Findlay BL;

Antibiotic resistance is a major threat to global health, claiming the lives of millions every year. With a nearly dry antibiotic development pipeline, novel strategies are urgently needed to combat resistant pathogens. One emerging strategy is the use of sequential antibiotic therapy, postulated to reduce the rate at which antibiotic resistance evolves. ...

Article GUID: 37726252


Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms

Author(s): Pando-Naude V; Matthews TE; Højlund A; Jakobsen S; Østergaard K; Johnsen E; Garza-Villarreal EA; Witek MAG; Penhune V; Vuust P;

The pleasurable urge to move to music (PLUMM) activates motor and reward areas of the brain and is thought to be driven by predictive processes. Dopamine in motor and limbic networks is implicated in beat-based timing and music-induced pleasure, suggesting a central role of basal ganglia (BG) dop ...

Article GUID: 37724707


Sensation seeking, drinking motives, and going out mediate the link between eveningness and alcohol use and problems in adolescence

Author(s): Rigó A; Tóth-Király I; Magi A; Eisinger A; Demetrovics Z; Urbán R;

The present study was aimed at obtaining a more comprehensive understanding of the possible mediating factors in the morningness-eveningness ? alcohol consumption relation. We explored the role of mediators such as sensation seeking, the frequency of going out in the evenings, and drinking motives. We tested the proposed mediation model via structural equ ...

Article GUID: 37722395


COVID-19 boosters versus primary series: update to a living review

Author(s): Nana Wu

No abstract available

Article GUID: 37722401


Modulation of cue value and the augmentation of heroin seeking in chronically food-restricted male rats under withdrawal

Author(s): Firas Sedki

Food restriction augments drug seeking in abstinent rats. The underlying motivational mechanisms, however, remain unclear. We hypothesized that caloric restriction enhances the incentive value attributed to drug-associated cues and, in turn, augments drug seeking. Male rats were trained to lever-press for heroin, and then moved to the animal colony for a ...

Article GUID: 37714221


TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions

Author(s): Almousa H; Lewis SA; Bakhtiari S; Nordlie SH; Pagnozzi A; Magee H; Efthymiou S; Heim JA; Cornejo P; Zaki MS; Anwar N; Maqbool S; Rahman F; Neilson DE; Vemuri A; Jin SC; Yang XR; Heidari A; van Gassen K; Trimouille A; Thauvin-Robinet C; L ...

Highly conserved transport protein particle (TRAPP) complexes regulate subcellular trafficking pathways. Accurate protein trafficking has been increasingly recognized to be critically important for normal development, particularly in the nervous system. Variants in most TRAPP complex subunits hav ...

Article GUID: 37713627


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