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Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1

Author(s): Kozlov G; Jiang J; Rutherford T; Noronha AM; Wilds CJ; Gehring K;

La-related proteins (LARPs) are a family of RNA-binding proteins that share a conserved La motif (LaM) domain. LARP1 plays a role in regulating ribosomal protein synthesis and stabilizing mRNAs and has a unique structure without an RNA binding RRM domain ad ...

Article GUID: 39016322


The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity

Author(s): Goldfield GS; Cameron JD; Sigal RJ; Kenny GP; Prud' homme D; Ngu M; Alberga AS; Doucette S; Goldfield DB; Tulloch H; Thai H; Simas KR; ...

The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-r ...

Article GUID: 38997217


pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings

Author(s): Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK; ...

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompat ...

Article GUID: 38989606


Metabolomics 2023 workshop report: moving toward consensus on best QA/QC practices in LC-MS-based untargeted metabolomics

Author(s): Mosley JD; Dunn WB; Kuligowski J; Lewis MR; Monge ME; Ulmer Holland C; Vuckovic D; Zanetti KA; Schock TB; ...

Introduction: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a QA/QC workshop for LC-MS-based untargeted metabolomics. ...

Article GUID: 38980450


Electroforming of Personalized Multi-Level and Free-Form Metal Parts Utilizing Fused Deposition Modeling-Manufactured Molds

Author(s): Hamed H; Aghili S; Wüthrich R; Abou-Ziki JD;

Adapting to the growing demand for personalized, small-batch manufacturing, this study explores the development of additively manufactured molds for electroforming personalized metal parts. The approach integrates novel multi-level mold design and fabricati ...

Article GUID: 38930706


Innovations and development of sustainable personal protective equipment: a path to a greener future

Author(s): Lyu L; Bagchi M; Markoglou N; An C;

The unprecedented surge in the demand for personal protective equipment (PPE) worldwide during the covid pandemic resulted in a significant increase in PPE consumption and subsequent waste generation. Despite the importance of PPE, its widespread usage and ...

Article GUID: 38911061


Cognitive Speed in Neurodegenerative Disease: Comparing Mean Rate and Inconsistency Within and Across the Alzheimer's and Lewy Body Spectra in the COMPASS-ND Study

Author(s): Caballero HS; McFall GP; Gee M; MacDonald S; Phillips NA; Fogarty J; Montero-Odasso M; Camicioli R; Dixon RA; ...

Background: Alzheimer's disease (AD) and Lewy body disease (LBD) are characterized by early and gradual worsening perturbations in speeded cognitive responses. Objective: Using simple and choi ...

Article GUID: 38875040


Bulk Free Radical Terpolymerization of Butyl Acrylate, 2-Methylene-1,3-Dioxepane and Vinyl Acetate: Terpolymer Reactivity Ratio Estimation

Author(s): Movafagh M; Meek KM; Scott AJ; Penlidis A; Dubé MA;

This investigation introduces the first estimation of ternary reactivity ratios for a butyl acrylate (BA), 2-methylene-1,3-dioxepane (MDO), and vinyl acetate (VAc) system at 50 °C, with an aim to develop biodegradable pressure-sensitive adhesives (PSAs). In ...

Article GUID: 38794524


Investigation of Macroscopic Mechanical Behavior of Magnetorheological Elastomers under Shear Deformation Using Microscale Representative Volume Element Approach

Author(s): Abdollahi I; Sedaghati R;

Magnetorheological elastomers (MREs) are a class of smart materials with rubber-like qualities, demonstrating revertible magnetic field-dependent viscoelastic properties, which makes them an ideal candidate for development of the next generation of adaptive ...

Article GUID: 38794567


Effect of support group peer facilitator training programmes on peer facilitator and support group member outcomes: a systematic review

Author(s): Delisle VC; Gumuchian ST; Kloda LA; Boruff J; El-Baalbaki G; Körner A; Malcarne VL; Thombs BD; ...

Objective: Peer facilitators play an important role in determining the success of many support groups for patients with medical illnesses. However, many facilitators do not receive ...

Article GUID: 27856483


The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks

Author(s): Alvarez MR; Alkaissi H; Rieger AM; Esber GR; Acosta ME; Stephenson SI; Maurice AV; Valencia LMR; Roman CA; Alarcon JM; ...

Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a potential activator of ...

Article GUID: 38549144


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