Author(s): Memari E; Singh D; Alkins R; Helfield B;

Cellular immunotherapy remains hindered in the context of solid tumors due to the immunosuppressive microenvironment, in which key endothelial cell adhesion molecules (CAM) are suppressed. Microbubble-mediated focused ultrasound is being explored for targeted immunotherapy and can exert local shear stress upon neighboring endothelial cells. However, fluid ...

Article GUID: 40657183

Author(s): Campbell JR; Russell WA; Wagner CE; Manuel DG; Anipindi V; Baral P; Evans TG; Hankins CA; Sander B;

The Government of Canada, through the COVID-19 Immunity Task Force (CITF), supported over 100 serosurveillance studies during the COVID-19 pandemic, building and strengthening the technical infrastructure necessary for a national serosurveillance network. The value of such a network extends beyon ...

Article GUID: 40588636

Author(s): Ren C; Cao SJ; Haghighat F;

During the ongoing COVID-19 pandemic period, the airborne transmission of viruses has raised widespread concern as daily activities are resumed in public buildings. It is essential to develop mitigation strategies of infection disease transmission (e.g., increase of ventilation rate) in different scenarios to reduce the infection risk. For classrooms in s ...

Article GUID: 40477856

Author(s): Rayegan S; Shu C; Berquist J; Jeon J; Zhou LG; Wang LL; Mbareche H; Tardif P; Ge H;

In the past few years, significant efforts have been made to investigate the transmission of COVID-19. This paper provides a review of the COVID-19 airborne transmission modeling and mitigation strategies. The simulation models here are classified into airborne transmission infectious risk models and numerical approaches for spatiotemporal airborne transm ...

Article GUID: 40478135

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519

Author(s): Sanami S; Intzandt B; Huck J; Villeneuve S; Iturria-Medina Y; Gauthier CJ; Prevent-Ad Research Group None;

Alzheimer's disease (AD) is a complex disease that involves complex interactions between protein biomarkers such as amyloid beta (Aß) and tau, neurodegeneration, cerebrovascular health and inflammation. However, how these factors interact, especially in the early phases of disease development ...

Article GUID: 40347524

Author(s): Cierson T; Zhao K; Belkhelladi M; Babouras A; Jing J; Faith J; Corban J; Martineau PA;

Background: Anterior cruciate ligament (ACL) injuries can pose significant challenges for athletes, leading to significant morbidity, loss of playing time, and impaired performance. Neuromuscular training programs, such as the FIFA 11+, have shown promise in reducing the risk of lower extremity injuries in this high-risk population. Purpose/hypothesis: T ...

Article GUID: 40303320

Author(s): Cruz-Santiago D; Meng X; Canac-Marquis M; Sengupta A; Brassard JP; Pavey E; Girouard H; Vinh DC; Gouin JP;

Background: SARS-CoV-2 infection can lead to persistent post-acute neuropsychiatric symptoms. Older adults with multimorbidity may be at increased risk of post-acute symptoms after COVID-19. The goals of the present study were to assess the associations of SARS-CoV-2 infection with neuropsychiatr ...

Article GUID: 40051588

Author(s): Tremblay N; Lavoie KL; Bacon SL; Bélanger-Gravel A;

Objectives: Throughout COVID-19, uncertain information on the virus and preventive measures circulated. Young adults, often relying on social rather than traditional media, showed lower adherence to recommendations. This study examines associations between information sources, attitudes toward public health measures and concerns among young adults. Study ...

Article GUID: 40043475

Author(s): Langmuir T; Wilson M; McCleary N; Patey AM; Mekki K; Ghazal H; Estey Noad E; Buchan J; Dubey V; Galley J; Gibson E; Fontaine G; Smith M; Alghamyan A; Thompson K; Crawshaw J; Grimshaw JM; Arnason T; Brehaut J; Michie S; Brouwers M; Presse ...

Background: Ensuring widespread COVID-19 vaccine uptake is a public health priority in Canada and globally, particularly within communities that exhibit lower uptake rates and are at a higher risk of infection. Public health units (PHUs) have leveraged many resources to promote the uptake of reco ...

Article GUID: 39891139

Author(s): Meek K; Movafagh M; Dubé MA;

The ring-opening polymerization of bio-based monomer 2-methylene-1,3-dioxepane (MDO) can reportedly enhance polymer degradability. Butyl acrylate (BA)/MDO/vinyl acetate (VAc) terpolymers were synthesized via emulsion polymerization for their eventual application as pressure-sensitive adhesives (PSAs). While using MDO in emulsion polymerization leads to a ...

Article GUID: 39719378