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Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood

Author(s): Won Kang JR; Kim YJ; Skead K; Soave D; Evans J; Bruat V; Harwood MP; Morris Q; Matovu E; Mulindwa J; Noyes H; McLeod A; Hazelhurst S; Lombard Z; Ramsay M; Fave MJ; Awadalla P;

Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have largely been characterized in individuals of European ancestry or environments, and consequently, it ...

Article GUID: 41282824


Spatio-temporal distribution of AOD and its response to regional energy consumption and air pollution factors in China

Author(s): Su Y; Chen X; Guo J; Yang A;

Aerosols serve as crucial indicators of air pollution assessment, and exert significant effects on climate change, ecological environment, and human health. However, the relationship between energy consumption, a significant contributor to air pollution, and aerosols in different economic development zones in China remains understudied. This paper employs ...

Article GUID: 41308902


Characterization of secreted epidermal patterning factor peptides and ERECTA family receptors as regulators for root hair development in em Arabidopsis thaliana /em

Author(s): Hamiditabar Z; Lee JS; Gulick PJ;

This study investigated the role of secreted peptides and receptors in root hair development. The secreted peptides EPF1, EPF2, EPFL4, EPFL5, EPFL6, and EPFL9 and their putative receptors ERECTA (ER), ERECTA-LIKE1 (ERL1), ERL2, and TMM were found to mediate the development of the root hairs in Arabidopsis under control conditions and in response to nitrat ...

Article GUID: 41280503


The Effect of a 10-Week Electromyostimulation Intervention with the StimaWELL 120MTRS System on Multifidus Morphology and Function in Chronic Low Back Pain Patients: A Randomized Controlled Trial

Author(s): Wolfe D; Rosenstein B; Dover G; Boily M; Fortin M;

Background: Chronic low back pain (CLBP) patients present with morphological and functional deficits to the lumbar multifidus. Electromyostimulation (EMS) can be used to improve activation and strength in atrophied skeletal muscle, but its effect on multifidus morphology and function in CLBP patients is understudied. The aims of this study were to compare ...

Article GUID: 41283552


From pollution barriers to health buffers: Rethinking building airtightness under climate variability

Author(s): Fu N; Zhang R; Haghighat F; Kumar P; Cao SJ;

Climate change is reshaping indoor-outdoor pollution dynamics, yet current building standards rarely reflect this shift. In rapidly urbanizing regions with high ambient PM2.5 levels, building airtightness offers an underutilized strategy to mitigate indoor exposure and associated health burdens. An analysis of 36 major Chinese cities across five climate z ...

Article GUID: 41252997


Mechanistic insights of plant-microbe interactions for enhancing the growth and productivity of plants under salt stress conditions for agricultural sustainability

Author(s): Sharma B; Negi R; Jyothi SR; Gupta A; Jhamta S; Yadav N; Kaur N; Puri P; Thakur SS; Bagavathiappan S; Thakur N; Shreaz S; Madouh TA; Yadav AN;

According to estimates from United Nations environmental program, salinity affects about 20% of agricultural land and 50% of farmland worldwide. Plants react to salinity stress by undergoing distinctive physiochemical, morphological, and molecular adaptations. Nonetheless, a number of mitigating ...

Article GUID: 41245209


Human short-term memory learning based on dynamic glutamate levels and oscillatory activities: concurrent metabolic and electrophysiological studies using event-related functional-MRS and EEG modalities

Author(s): Mohammadi H; Zargaran SJ; Khajehpour H; Adibi I; Rahimiforoushani A; Karimi S; Serej ND; Alam NR;

Short-term memory (STM) temporarily stores sensory information, critical for synaptic plasticity, memory, and learning, and is regulated by the glutamate-gated NMDA receptor. While the frontal and parieto-occipital cortices have been implicated in STM, the electrochemical dynamics of the right he ...

Article GUID: 41171530


Parents Experiences and Clinicians Perceptions of Managing Cancer Pain in Young Children at Home

Author(s): Jibb LA; Hashemi E; Sivaratnam S; Hildenbrand AK; Nathan PC; Chartrand J; Alberts NM; Masama T; Pease HG; Torres LB; Cortes HG; Zworth M; Kuczynski S; Fortier MA;

Background: Pain is a prevalent and distressing symptom for children with cancer, negatively affecting quality of life and family functioning. While most research focuses on hospital-based care, many pain episodes occur at home, where parents act as primary caregivers with limited access to evide ...

Article GUID: 41149458


The Bug-Network (BugNet): A Global Experimental Network Testing the Effects of Invertebrate Herbivores and Fungal Pathogens on Plant Communities and Ecosystem Function in Open Ecosystems

Author(s): Kempel A; Adamidis GC; Anadón JD; Atkinson J; Auge H; Avtzis D; Bachelot B; Bashirzadeh M; Bota JL; Classen A; Constantinou I; Crawley M; de Bellis T; Dostal P; Ebeling A; Eisenhauer N; Eldridge DJ; Encina G; Estrada C; Everingham S; Fan ...

Plants are consumed by a variety of organisms, including herbivores and pathogens, which significantly impact plant biomass, diversity, community composition, and ecosystem functioning. While the impacts of vertebrate herbivores are well established, the effects of consumer groups such as insect ...

Article GUID: 41080499


Cerebral small vessel disease lesion segmentation methods: A systematic review

Author(s): Phelps J; Singh M; McCreary CR; Dallaire-Théroux C; Stein RG; Potvin-Jutras Z; Guan DX; Wu JD; Metz A; Smith EE;

Cerebral small vessel disease (CSVD) can manifest as brain lesions visible on magnetic resonance imaging, including white matter hyperintensities (WMH), cerebral microbleeds (CMB), perivascular spaces (PVS), lacunes, and recent small subcortical infarcts (RSSI). Detection and segmentation of thes ...

Article GUID: 41080650


Mapping the distribution of contaminants identified by non-targeted screening of passively sampled urban air

Author(s): Liu L; Gillet AP; Akiki C; Tian L; Ma Y; Zhang X; Bowman DT; Wania F; Delbès G; Apparicio P; Bayen S;

Air pollution is closely associated with increased lung cancer incidence and mortality. Because many semi-volatile industrial chemicals, pesticides and combustion by-products are endocrine-disrupting or genotoxic, their mixtures in outdoor urban air, even at trace levels, could have cumulative ef ...

Article GUID: 41033295


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