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Evidence of isochorismate channeling between the Escherichia coli enterobactin biosynthetic enzymes EntC and EntB

Author(s): Bin X; Pawelek PD;

Enterobactin is a high-affinity iron chelator produced and secreted by Escherichia coli and Salmonella typhimurium to scavenge scarce extracellular Fe3+ as a micronutrient. EntC and EntB are the first two enzymes in the enterobactin biosynthetic pathway. Is ...

Article GUID: 39031458


Beyond struggle: A strengths-based qualitative study of cannabis use among queer and trans youth in Québec

Author(s): London-Nadeau K; Lafortune C; Gorka C; Lemay-Gaulin M; Séguin J; Haines-Saah R; Ferlatte O; Chadi N; Juster RP; Bristowe S; D' Alessio ...

Background: Queer and trans (QT) youth report higher rates of cannabis use than their cisgender and heterosexual peers. Explanations for this have overwhelmingly focused on the difficulties QT yout ...

Article GUID: 38991874


Metabolomics 2023 workshop report: moving toward consensus on best QA/QC practices in LC-MS-based untargeted metabolomics

Author(s): Mosley JD; Dunn WB; Kuligowski J; Lewis MR; Monge ME; Ulmer Holland C; Vuckovic D; Zanetti KA; Schock TB; ...

Introduction: During the Metabolomics 2023 conference, the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) presented a QA/QC workshop for LC-MS-based untargeted metabolomics. ...

Article GUID: 38980450


Connectivity preservation control for multiple unmanned aerial vehicles in the presence of bounded actuation

Author(s): Xue X; Yuan B; Yi Y; Zhang Y; Yue X; Mu L;

This paper proposes a novel multi-unmanned aerial vehicle (UAV) connectivity preservation controller, suitable for scenarios with bounded actuation and limited communication range. According to the hierarchical control strategy, controllers are designed sep ...

Article GUID: 38964998


A usability analysis of augmented reality and haptics for surgical planning

Author(s): Kazemipour N; Hooshiar A; Kersten-Oertel M;

Purpose: Proper visualization and interaction with complex anatomical data can improve understanding, allowing for more intuitive surgical planning. The goal of our work was to study what the most intuitive yet practical platforms for interacting with 3D me ...

Article GUID: 38942947


Exploiting protein language models for the precise classification of ion channels and ion transporters

Author(s): Ghazikhani H; Butler G;

This study introduces TooT-PLM-ionCT, a comprehensive framework that consolidates three distinct systems, each meticulously tailored for one of the following tasks: distinguishing ion channels (ICs) from membrane proteins (MPs), segregating ion transporters ...

Article GUID: 38656743


Medical Cannabis Use Among Canadian Veterans and Non-Veterans: A National Survey

Author(s): Valikhanova G; Kato Y; Fitzcharles MA; Ware M; Da Costa D; Lowensteyn I; Cheung HS; Grover S; ...

Background: Medical cannabis (MC) is used by Canadian Veterans to manage a wide range of health issues. However, there is little information comparing the reasons for MC use and its perceived effec ...

Article GUID: 37920683


Identification of a Conserved Transcriptional Activator-Repressor Module Controlling the Expression of Genes Involved in Tannic Acid Degradation and Gallic Acid Utilization in Aspergillus niger

Author(s): Arentshorst M; Falco MD; Moisan MC; Reid ID; Spaapen TOM; van Dam J; Demirci E; Powlowski J; Punt PJ; Tsang A; Ram AFJ; ...

Tannic acid, a hydrolysable gallotannin present in plant tissues, consists of a central glucose molecule esterified with gallic acid molecules. Some microorganisms, including several Aspergillus sp ...

Article GUID: 37744122


A comparative study of black-box and white-box data-driven methods to predict landfill leachate permeability

Author(s): Ghasemi M; Samadi M; Soleimanian E; Chau KW;

Due to the dynamic and complexity of leachate percolation within municipal solid waste (MSW), planning and operation of solid waste management systems are challenging for decision-makers. In this regard, data-driven methods can be considered robust approach ...

Article GUID: 37335361


An electrochemical aptasensor for Δ9-tetrahydrocannabinol detection in saliva on a microfluidic platform

Author(s): Kékedy-Nagy L; Perry JM; Little SR; Llorens OY; Shih SCC;

We present a novel "on-off", cost-effective, rapid electrochemical aptasensor combined with a microfluidics cartridge system for the detection of ?9-THC (?9-tetrahydrocannabinol) in human saliva via differential pulse voltammetry. The assay relied on the co ...

Article GUID: 36549107


Structural determination and anticholinesterase assay of C-glycosidic ellagitannins from Lawsonia inermis leaves: A study supported by DFT calculations and molecular docking

Author(s): Orabi MAA; Orabi EA; Abdel-Sattar ES; English AM; Hatano T; Elimam H;

An ellagitannin monomer, lythracin M (1), and a dimer, lythracin D (2), along with eight known monomers (3-10) were isolated from Lawsonia inermis (Lythraceae) leaves. Lythracin M (1) is a C-glycosidic ellagitannin with a flavogallonyl dilactone moiety that ...

Article GUID: 36423882


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