Author(s): Chae Y; Cheers GM; Kim M; Reidler P; Klein A; Fevens T; Holzapfel BM; Mayer-Wagner S;

Cavitary bone defects, defined as a volumetric loss of native bone tissue, require accurate preoperative imaging for treatment planning. While CT (computed tomography) has traditionally been the gold standard for segmentation due to its superior resolution of cortical bone, MRI (magnetic resonance imaging) offers unique advantages, particularly in visuali ...

Article GUID: 40049253

Author(s): Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T;

Introduction: Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied. Methods: We assessed cross-sectionally wh ...

Article GUID: 39989020

Author(s): Pereira M; Chen X; Paltarzhytskaya A; Pache?o Y; Muller N; Bovy L; Lei X; Chen W; Ren H; Song C; Lewis LD; Dang-Vu TT; Czisch M; Picchioni D; Duyn J; Peigneux P; Tagliazucchi E; Dresler M;

Sleep research has evolved considerably since the first sleep electroencephalography recordings in the 1930s and the discovery of well-distinguishable sleep stages in the 1950s. While electrophysiological recordings have been used to describe the sleeping brain in much detail, since the 1990s neu ...

Article GUID: 39940102

Author(s): Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; Van Haaften-Visser DY; Nieuwenhuis ESS; Jackson SP; Fuchs SA; Wijk F; van Hasselt P;

Background: Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenicity and pathophysiology. To address this challenge, we propose a high-through ...

Article GUID: 39920830

Author(s): Felismino MEL; Chevallier Rufigny S; Gonzalez-Fleurant SE; Brown GE;

Microplastics, particles between 0.001 and 5 mm in diameter, are ubiquitous in the environment and their consumption by aquatic organisms is known to lead to a variety of adverse effects. However, studies on the effects of microplastics on prey fish have not shown consistent trends, with results varying across species and plastic type used. Here, we manip ...

Article GUID: 39862685

Author(s): Yusefi H; Helfield B;

Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1-8 µm in diameter, with a volume-weighted mean size of 2-3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing success as a local therapeutic vector, the fundamental interplay between microbubbles - including bubbl ...

Article GUID: 39705920

Author(s): McKay MJ; Weber KA; Wesselink EO; Smith ZA; Abbott R; Anderson DB; Ashton-James CE; Atyeo J; Beach AJ; Burns J; Clarke S; Collins NJ; Coppieters MW; Cornwall J; Crawford RJ; De Martino E; Dunn AG; Eyles JP; Feng HJ; Fortin M; Franettovic ...

Disorders affecting the neurological and musculoskeletal systems represent international health priorities. A significant impediment to progress in trials of new therapies is the absence of responsive, objective, and valid outcome measures sensitive to early disease changes. A key finding in indi ...

Article GUID: 39590726

Author(s): Joyal M; Sicard A; Penhune V; Jackson PL; Tremblay P;

Despite the ubiquity of musical activities, little is known about the specificity of their association with executive functions. In this cross-sectional study, we examined this relationship as a function of age. Our main hypotheses were that executive functions would decline in older age, that this relationship would be reduced in singers and instrumental ...

Article GUID: 39367878

Author(s): Samuel Olajide T; Oyerinde TO; Omotosho OI; Okeowo OM; Olajide OJ; Ijomone OM;

The existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the understanding of the diverse clinical manifestations of individual NDDs. Dementia, a hallmark symptom acro ...

Article GUID: 39364217

Author(s): D' Arcey J; Torous J; Asuncion TR; Tackaberry-Giddens L; Zahid A; Ishak M; Foussias G; Kidd S;

Background: Digital mental health is a rapidly growing field with an increasing evidence base due to its potential scalability and impacts on access to mental health care. Further, within underfunded service systems, leveraging personal technologies to deliver or support specialized service deliv ...

Article GUID: 39348196

Author(s): Tarmoun K; Lachance V; Le Corvec V; Bélanger SM; Beaucaire G; Kourrich S;

Sigma-1R (S1R) is a ubiquitously distributed protein highly expressed in the brain and liver. It acts as a ligand-inducible chaperone protein localized at the endoplasmic reticulum. S1R participates in several signaling pathways that oversee diverse cellular and neurological functions, such as calcium and proteome homeostasis, neuronal activity, memory, a ...

Article GUID: 39335377