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Understanding Fluconazole Tolerance in Candida albicans: Implications for Effective Treatment of Candidiasis and Combating Invasive Fungal Infections

Author(s): Feng Y; Lu H; Whiteway M; Jiang Y;

Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal diseases (IFDs) cause ...

Article GUID: 37918789


Data-Weighted Multivariate Generalized Gaussian Mixture Model: Application to Point Cloud Robust Registration

Author(s): Ge B; Najar F; Bouguila N;

In this paper, a weighted multivariate generalized Gaussian mixture model combined with stochastic optimization is proposed for point cloud registration. The mixture model parameters of the target scene and the scene to be registered are updated iteratively ...

Article GUID: 37754943


Negotiating Experiences of Belonging Alongside Age-Related Life Transitions

Author(s): Fortune D; Weisgarber B;

Belonging is a pervasive human need that is vital to our well-being as we age. Ageist attitudes, stereotyping, and life transitions tend to jeopardise older adults' experiences of belonging. Although community involvement can lead to the development of ...

Article GUID: 37518953


Understanding National Nonprofit Data Environments

Author(s): Bloodgood EA; Bourns J; Lenczner M; Shibaike T; Tabet J; Melvin A; Wong WH;

We develop the concept of the nonprofit data environment as all data collected and reported in a country resulting from law implemented into practice. We map data environments across 20 countries and propose explanations for differences between the informat ...

Article GUID: 36974198


Double-Bind of Recruitment of Older Adults Into Studies of Successful Aging via Assistive Information and Communication Technologies: Mapping Review

Author(s): Khalili-Mahani N; Sawchuk K;

Background: Two fields of research and development targeting the needs of the aging population of the world are flourishing, successful aging and assistive information and communication technologies (A-ICTs). The risks of ageist stereotypes emerging from ho ...

Article GUID: 36563033


Robust landmark-based brain shift correction with a Siamese neural network in ultrasound-guided brain tumor resection

Author(s): Pirhadi A; Salari S; Ahmad MO; Rivaz H; Xiao Y;

Purpose: In brain tumor surgery, tissue shift (called brain shift) can move the surgical target and invalidate the surgical plan. A cost-effective and flexible tool, intra-operative ultrasound (iUS) with robust image registration algorithms can effectively ...

Article GUID: 36306056


DiffeoRaptor: diffeomorphic inter-modal image registration using RaPTOR

Author(s): Masoumi N; Rivaz H; Ahmad MO; Xiao Y;

Purpose: Diffeomorphic image registration is essential in many medical imaging applications. Several registration algorithms of such type have been proposed, but primarily for intra-contrast alignment. Currently, efficient inter-modal/contrast diffeomorphic ...

Article GUID: 36173541


Assessing the coastal sensitivity to oil spills from the perspective of ecosystem services: A case study for Canada's pacific coast

Author(s): Feng Q; An C; Chen Z; Owens E; Niu H; Wang Z;

Coastal environment is one of the most important ecological and socioeconomic areas. However, increasing energy demand and economic development lead to a continuous gas and oil exploration, production, and traffics, which notably raise the risk of oil spill ...

Article GUID: 34271360


Multimodal 3D ultrasound and CT in image-guided spinal surgery: public database and new registration algorithms

Author(s): Masoumi N; Belasso CJ; Ahmad MO; Benali H; Xiao Y; Rivaz H;

Purpose: Accurate multimodal registration of intraoperative ultrasound (US) and preoperative computed tomography (CT) is a challenging problem. Construction of public datasets of US and CT images can accelerate the development of such image registration tec ...

Article GUID: 33683544


Candida albicans targets that potentially synergize with fluconazole.

Author(s): Lu H, Shrivastava M, Whiteway M, Jiang Y

Fluconazole has characteristics that make it widely used in the clinical treatment of C. albicans infections. However, fluconazole has only a fungistatic activity in C. albicans, therefore, in the long-term treatment of C. albicans infection with fluconazol ...

Article GUID: 33587857


Expression of catalytically efficient xylanases from thermophilic fungus Malbranchea cinnamomea for synergistically enhancing hydrolysis of lignocellulosics.

Author(s): Basotra N, Joshi S, Satyanarayana T, Pati PK, Tsang A, Chadha BS

Int J Biol Macromol. 2018 Mar;108:185-192 Authors: Basotra N, Joshi S, Satyanarayana T, Pati PK, Tsang A, Chadha BS

Article GUID: 29174359


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