Author(s): Clarke SH; Lawrence ER; Matte JM; Gallagher BK; Salisbury SJ; Michaelides SN; Koumrouyan R; Ruzzante DE; Grant JWA; Fraser DJ; ...

Effective population size (Ne) is a particularly useful metric for conservation as it affects genetic drift, inbreeding and adaptive potential within populations. Current guidelines recommend a min ...

Article GUID: 38613250

Author(s): Lawrence ER; Pedersen EJ; Fraser DJ;

The broad scale distribution of population-specific genetic diversity (GDP ) across taxa remains understudied relative to species diversity gradients, despite its relevance for systematic conservation planning. We used nuclear DNA data collected from 3678 v ...

Article GUID: 37365672

Author(s): Clarke SH; McCracken GR; Humphries S; Ruzzante DE; Grant JWA; Fraser DJ;

Sustainable management of exploited populations benefits from integrating demographic and genetic considerations into assessments, as both play a role in determining harvest yields and population persistence. This is especially important in populations subj ...

Article GUID: 36426123

Author(s): Quevedo Y; Booij L; Herrera L; Hernández C; Jiménez JP;

Genetic and early environmental factors are interwoven in the etiology of Borderline Personality Disorder (BPD). Epigenetic mechanisms offer the molecular machinery to adapt to environmental conditions. There are gaps in the knowledge about how epigenetic m ...

Article GUID: 36171872

Author(s): Azar N; Booij L;

Background: Prenatal maternal stress is increasingly recognized as a risk factor for offspring mental health challenges. DNA methylation may be a mechanism, but few studies directly tested mediation. These few integrative studies are reviewed along with stu ...

Article GUID: 36113690

Author(s): Schmidt C; Muñoz G; Lancaster LT; Lessard JP; Marske KA; Marshall KE; Garroway CJ;

Global biodiversity is organised into biogeographic regions that comprise distinct biotas. The contemporary factors maintaining differences in species composition between regions are poorly understood. Given evidence that populations with sufficient genetic ...

Article GUID: 35753949

Author(s): Steiger H; Booij L; Thaler L; St-Hilaire A; Israël M; Casey KF; Oliverio S; Crescenzi O; Lee V; Turecki G; Joober R; Szyf M; Breton É; ...

bjectives: Recent studies have reported altered methylation levels at disorder-relevant DNA sites in people who are ill with Anorexia Nervosa (AN) compared to findings in people with no eating diso ...

Article GUID: 35703085

Author(s): Abicumaran Uthamacumaran

Cancers are complex dynamic ecosystems. Reductionist approaches to science are inadequate in characterizing their self-organized patterns and collective emergent behaviors. Since current approaches to single-cell analysis in cancer systems rely primarily on ...

Article GUID: 35678918

Author(s): Breton E; Fotso Soh J; Booij L;

Obesity and eating disorders are conditions that involve eating behaviors and are sometimes comorbid. Current evidence supports alterations in immunoinflammatory processes in both obesity and eating disorders. A plausible hypothesis is that immunoinflammato ...

Article GUID: 35594735

Author(s): Villaruel FR; Martins M; Chaudhri N;

The capacity to suppress learned responses is essential for animals to adapt in dynamic environments. Extinction is a process by which animals learn to suppress conditioned responding when an expected outcome is omitted. The infralimbic cortex (IL) to nucle ...

Article GUID: 34880119

Author(s): Pallikaras V; Carter F; Velazquez-Martinez DN; Arvanitogiannis A; Shizgal P;

Optogenetic experiments reveal functional roles of specific neurons. However, functional inferences have been limited by widespread adoption of a restricted set of stimulation parameters. Broader exploration of the parameter space can deepen insight into th ...

Article GUID: 34864162