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An Automated Single-Cell Droplet-Digital Microfluidic Platform for Monoclonal Antibody Discovery

Author(s): Ahmadi F; Tran H; Letourneau N; Little SR; Fortin A; Moraitis AN; Shih SCC;

Monoclonal antibody (mAb) discovery plays a prominent role in diagnostic and therapeutic applications. Droplet microfluidics has become a standard technology for high-throughput screening of antibody-producing cells due to high droplet single-cell confineme ...

Article GUID: 38441226


Nonlinear dynamic modeling and model-based AI-driven control of a magnetoactive soft continuum robot in a fluidic environment

Author(s): Moezi SA; Sedaghati R; Rakheja S;

In recent years, magnetoactive soft continuum robots (MSCRs) with multimodal locomotion capabilities have emerged for various biomedical applications. Developments in nonlinear dynamic models and effective control methods for MSCRs are deemed vital not only ...

Article GUID: 37932207


Measuring prion propagation in single bacteria elucidates a mechanism of loss

Author(s): Jager K; Orozco-Hidalgo MT; Springstein BL; Joly-Smith E; Papazotos F; McDonough E; Fleming E; McCallum G; Yuan AH; Hilfinger A; Hochschild ...

Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathi ...

Article GUID: 37738299


Assessing pragmatics in early childhood with the Language Use Inventory across seven languages

Author(s): Pesco D; O' Neill DK;

The Language Use Inventory (LUI) is a parent-report measure of the pragmatic functions of young children's language, standardized and norm-referenced in English (Canada) for children aged 18-47 months. The unique focus of the LUI, along with its appeal ...

Article GUID: 37408974


Preparation, characteristics, and performance of the microemulsion system in the removal of oil from beach sand

Author(s): Bi H; Mulligan CN; Lee K; An C; Wen J; Yang X; Lyu L; Qu Z;

Oil deposited on shoreline substrates has serious adverse effects on the coastal environment and can persist for a long time. In this study, a green and effective microemulsion (ME) derived from vegetable oil was developed as a washing fluid to remove stran ...

Article GUID: 37399736


Microfluidic Wound-Healing Assay for ECM and Microenvironment Properties on Microglia BV2 Cells Migration

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Microglia cells, as the resident immune cells of the central nervous system (CNS), are highly motile and migratory in development and pathophysiological conditions. During their migration, microglia cells interact with their surroundings based on the variou ...

Article GUID: 36832056


An electrochemical aptasensor for Δ9-tetrahydrocannabinol detection in saliva on a microfluidic platform

Author(s): Kékedy-Nagy L; Perry JM; Little SR; Llorens OY; Shih SCC;

We present a novel "on-off", cost-effective, rapid electrochemical aptasensor combined with a microfluidics cartridge system for the detection of ?9-THC (?9-tetrahydrocannabinol) in human saliva via differential pulse voltammetry. The assay relied on the co ...

Article GUID: 36549107


A pH-Responsive phosphoprotein washing fluid for the removal of phenanthrene from contaminated peat moss in the cold region

Author(s): Yue R; An C; Ye Z; Li X; Li Q; Zhang P; Qu Z; Wan S;

Oil pollution is one of the major environmental concerns in the petroleum industry. In this study, a cheap food-grade sodium caseinate (NaCas) was used as a pH-responsive washing fluid in the remediation of phenanthrene (PHE) affected peat moss. The effects ...

Article GUID: 36455665


Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications

Author(s): Allard P; Papazotos F; Potvin-Trottier L;

Cells are inherently dynamic, whether they are responding to environmental conditions or simply at equilibrium, with biomolecules constantly being made and destroyed. Due to their small volumes, the chemical reactions inside cells are stochastic, such that ...

Article GUID: 36312536


Microfluidics in smart packaging of foods

Author(s): Pou KRJ; Raghavan V; Packirisamy M;

The increasing trend in ensuring safe and quality foods necessitates the monitoring of food products throughout the food supply chain. Food packaging is an indispensable process as it provides various functions such as containment, protection, convenience, ...

Article GUID: 36192908


Exploring the characteristics, performance, and mechanisms of a magnetic-mediated washing fluid for the cleanup of oiled beach sand

Author(s): Yue R; An C; Ye Z; Chen X; Lee K; Zhang K; Wan S; Qu Z;

In the present study, an innovative, environmentally benign recyclable, and magnetically mediated surface washing fluid based on water-dispersible magnetite nanoparticles has been designed and investigated for the cleanup of oiled beach sand. The characteri ...

Article GUID: 35780732


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