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Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans

Author(s): Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y;

Candidiasis, which presents a substantial risk to human well-being, is frequently treated with azoles. However, drug-drug interactions caused by azoles inhibiting the human CYP3A4 enzyme, together with increasing resistance of Candida species to azoles, rep ...

Article GUID: 38995235


Mechanisms and controlling factors of heavy metals removal by electroflocculation in estuarine environments

Author(s): Hadikhani R; Karbassi A; Tajziehchi S; Mehdizadeh Y;

Estuaries play a crucial role in preventing the influx of metals from rivers into seas, thereby offering potential insights for the water purification industry. This study seeks to identify the key parameters (including pH, electricity conductivity (EC), an ...

Article GUID: 38991606


The impact of directed choice on the design of preventive healthcare facility network under congestion

Author(s): Vidyarthi N; Kuzgunkaya O;

Preventive healthcare (PH) programs and services aim at reducing the likelihood and severity of potentially life-threatening illness by early detection and prevention. The effectiveness of these programs depends on the participation level and the accessibil ...

Article GUID: 24879402


Exploring the challenges of avoiding collisions with virtual pedestrians using a dual-task paradigm in individuals with chronic moderate to severe traumatic brain injury

Author(s): de Aquino Costa Sousa T; Gagnon IJ; Li KZH; McFadyen BJ; Lamontagne A;

Background: Individuals with a moderate-to-severe traumatic brain injury (m/sTBI), despite experiencing good locomotor recovery six months post-injury, face challenges in adapting their locomotion to the environment. They also present with altered cognitive ...

Article GUID: 38755606


All together now: Assessing variation in maternal and nonmaternal handling of wild Colobus vellerosus infants

Author(s): King AG; Rissling T; Cote S; Sicotte P;

Primatologists have a long-standing interest in the study of maternal care and nonmaternal handling (NH) of infants stemming from recognition that early social relationships can have enduring consequences. Though maternal care and NH often include expressio ...

Article GUID: 38654439


ALBA: a model-driven framework for the automatic generation of android location-based apps

Author(s): Gharaat M; Sharbaf M; Zamani B; Hamou-Lhadj A;

In recent years, the number of smartphone users has increased dramatically. These users download millions of apps and use them for various services. Due to the significant demand for mobile apps, developers often seek faster development methods and more eff ...

Article GUID: 38624616


Numerical Simulation of the Effect of Particle and Substrate Preheating on Porosity Level and Residual Stress of As-sprayed Ti6Al4V Components

Author(s): Khamsepour P; Moreau C; Dolatabadi A;

Nowadays, in the aerospace industry, additive manufacturing and repairing damaged metallic components like Ti6Al4V samples have grabbed attention. Among repairing techniques, solid-state additive manufacturing processes like cold spray are promising because ...

Article GUID: 38624932


Design, Synthesis, and Acid-Responsive Disassembly of Shell-Sheddable Block Copolymer Labeled with Benzaldehyde Acetal Junction

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK;

Smart nanoassemblies degradable through the cleavage of acid-labile linkages have attracted significant attention because of their biological relevance found in tumor tissues. Despite their high potential to achieve controlled/enhanced drug release, a syste ...

Article GUID: 38499007


Microhabitat conditions drive uncertainty of risk and shape neophobic responses in Trinidadian guppies, Poecilia reticulata

Author(s): Feyten LEA; Ramnarine IW; Brown GE;

In response to uncertain risks, prey may rely on neophobic phenotypes to reduce the costs associated with the lack of information regarding local conditions. Neophobia has been shown to be driven by information reliability, ambient risk and predator diversi ...

Article GUID: 37753307


Spin-dependent polarization and quantum Hall conductivity in decorated graphene: influence of locally induced spin-orbit-couplings and impurities

Author(s): Belayadi A; Vasilopoulos P;

We study spin transport through graphene-like substrates in the presence of one or several, locally induced spin-orbit coupling (SOC) terms resulting from periodically placed strips, on their top and decorated with a random distribution of impurities. Intri ...

Article GUID: 37230067


EEG complexity during mind wandering: A multiscale entropy investigation

Author(s): Cnudde K; Kim G; Murch WS; Handy TC; Protzner AB; Kam JWY;

Our attention often drifts away from the ongoing task to task-unrelated thoughts, a phenomenon commonly referred to as mind wandering. Ample studies dedicated to delineating its electrophysiological correlates have revealed distinct event-related potentials ...

Article GUID: 36621593


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