Feasibility and preliminary efficacy of the LEAD trial: a cluster randomized controlled lifestyle intervention to improve hippocampal volume in older adults at-risk for dementia
 
				Authors: N D Koblinsky
 
				
				
				
				Affiliations
				
					1 Rotman Research Institute, Baycrest Health Sciences, Toronto, Canada. 
 
 
 
 
 2 Rotman Research Institute, Baycrest Health Sciences, Toronto, Canada. nanderson@research.baycrest.org. 
 
 
 
 
 3 Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada. nanderson@research.baycrest.org. 
 
 
 
 
 4 KITE, Toronto Rehabilitation Institute - the University Health Network, Toronto, Canada. 
 
 
 
 
 5 PERFORM Centre, Concordia University, Montreal, Canada. 
 
 
 
 
 6 Department of Occupational Sciences and Occupational Therapy and Rehabilitation Sciences Institute, University of Toronto, Toronto, Canada. 
 
 
 
 
 7 Hurvitz Brain Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, Canada. 
 
 
 
 
 8 University of Waterloo, Waterloo, Canada. 
 
 
 
 
 9 Montreal Heart Institute Research Centre, Montreal, Canada. 
 
 
 
 
 10 Department of Nutrition, Université de Montréal, Montreal, Canada. 
 
 
 
 
 11 Department of Nutritional Sciences, University of Toronto, Toronto, Canada. 
				
				
				
				Description
					
					CONCLUSIONS: High adherence and retention rates were observed among participants and preliminary findings illustrate improvements in diet quality and HbA1c. These results indicate that a larger trial is feasible if difficulties surrounding recruitment can be mitigated.
				
 
				
					
					Keywords: Diet;  Early MCI;  Exercise;  Feasibility;  Intervention;  Subjective cognitive decline;  Vascular risk factors;  
 
				
				
				
				Links
				PubMed: https://pubmed.ncbi.nlm.nih.gov/35139918/
 
				
					DOI: 10.1186/s40814-022-00977-6