Author(s): Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y;

Candidiasis, which presents a substantial risk to human well-being, is frequently treated with azoles. However, drug-drug interactions caused by azoles inhibiting the human CYP3A4 enzyme, together with increasing resistance of Candida species to azoles, rep ...

Article GUID: 38995235

Author(s): Abkar L; Aghili Mehrizi A; Jafari M; Beck SE; Ghassemi A; Van Loosdrecht MCM;

Reverse osmosis (RO) systems offer a viable solution for treating brackish water (BW), a common but underutilized water resource. However, the energy-intensive nature of brackish water reverse osmosis (BWRO) systems poses affordability challenges to water s ...

Article GUID: 38688362

Author(s): Ghazikhani H; Butler G;

This study introduces TooT-PLM-ionCT, a comprehensive framework that consolidates three distinct systems, each meticulously tailored for one of the following tasks: distinguishing ion channels (ICs) from membrane proteins (MPs), segregating ion transporters ...

Article GUID: 38656743

Author(s): Mahdavi M; Findlay BL;

Infections caused by antibiotic-resistant bacteria are a major threat to health, increasing mortality rates and straining health systems worldwide. Adjuvants targeted to beta-lactamase function are able to resensitize bacteria to beta-lactam antibiotics, bu ...

Article GUID: 38096681

Author(s): Alebrahim E; Moreau C;

This study investigated the performance of photocatalytic titanium dioxide microfiltration membranes with an average pore size of approximately 180 nm and ultrafiltration membranes with an average pore size of around 40 nm fabricated with the suspension pla ...

Article GUID: 37755172

Author(s): Bani-Melhem K; Elektorowicz M; Tawalbeh M; Al Bsoul A; El Gendy A; Kamyab H; Yusuf M;

Polycyclic aromatic hydrocarbons (PAHs) are present in wastewater from various sources like industry, roads, and household waste. They are difficult to remove due to their low concentration, stability, and ability to combine with other organic substances. T ...

Article GUID: 37536541

Author(s): Ghazikhani H; Butler G;

Transmembrane transport proteins (transporters) play a crucial role in the fundamental cellular processes of all organisms by facilitating the transport of hydrophilic substrates across hydrophobic membranes. Despite the availability of numerous membrane pr ...

Article GUID: 37497772

Author(s): Keramatnejad M; DeWolf C;

Ozone exposure from environmental smog has been implicated as a risk factor for developing dry eye disease (DED). The tear film lipid layer (TFLL), which is the outermost layer of the tear film and responsible for surface tension reduction while blinking, i ...

Article GUID: 36837668

Author(s): Keramatnejad M; DeWolf C;

Tear film lipid layer (TFLL), the final layer of the human tear film is responsible for surface tension reduction while blinking, water evaporation retardation and maintaining the stability of the tear film. The study of the composition-structure-function r ...

Article GUID: 36535341

Author(s): Asadi P; Milev MP; Saint-Dic D; Gamberi C; Sacher M;

Mutations in the Transport and Golgi Organization 2 (TANGO2) gene are associated with intellectual deficit, neurodevelopmental delay and regression. Individuals can also present with an acute metabolic crisis that includes rhabdomyolysis, cardiomyopathy and ...

Article GUID: 36502486

Author(s): He S; Singh D; Helfield B;

Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease. Indeed, the plasma membrane represents a significant barrier to successful del ...

Article GUID: 35456718