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Tri-Functional CRISPR Screen Reveals Overexpression of em QDR2 /em and em QDR3 /em Transporters Increase Fumaric Acid Production in em Kluyveromyces marxianus /em

Author(s): Thornbury M; Omran RP; Kumar L; Knoops A; Abushahin R; Whiteway M; Martin VJJ;

Organic acids such as fumaric acid are widely used in the food and beverage industry as acidulants and preservatives, while also serving as versatile precursors for industrially relevant compounds. Fumaric acid is still predominantly produced through petroleum-derived processes. To enhance production efficiency and diversify supply, we are engineering Klu ...

Article GUID: 41277095


Substituted diphenylamine antioxidants and synthetic phenolic antioxidants in leachate from domestic landfills in China: Occurrence and removal via treatment

Author(s): Zhang LH; Chen F; Zhang XM; Zhang X; Liang B; Bai SS; Zhang ZF; Li YF; Ren NQ;

Substituted diphenylamine antioxidants (SDPAs) and synthetic phenolic antioxidants (SPAs), widely used in rubber and consumer products, pose growing environmental concerns. This study evaluated the occurrence and release of 43 SDPAs and 4 SPAs in raw leachate and treated effluent from 18 municipal landfills across China. Results showed 17 SDPAs and 1 SPA ...

Article GUID: 41270417


From pollution barriers to health buffers: Rethinking building airtightness under climate variability

Author(s): Fu N; Zhang R; Haghighat F; Kumar P; Cao SJ;

Climate change is reshaping indoor-outdoor pollution dynamics, yet current building standards rarely reflect this shift. In rapidly urbanizing regions with high ambient PM2.5 levels, building airtightness offers an underutilized strategy to mitigate indoor exposure and associated health burdens. An analysis of 36 major Chinese cities across five climate z ...

Article GUID: 41252997


Methotrexate plus low-dose prednisolone compared with high-dose corticosteroid therapy in the management of idiopathic granulomatous mastitis

Author(s): Shojaee L; Nafissi N; Roodposhti FN; Shakeriastani K; Shakeriastani K;

Purpose: Idiopathic granulomatous mastitis (IGM) is a chronic, relapsing inflammatory breast disease of unknown etiology. Its unpredictable course and unclear pathogenesis have made treatment a persistent clinical challenge. This study aimed to evaluate treatment outcomes in patients with IGM, focusing on extending remission periods and reducing relapse r ...

Article GUID: 41251719


Imagining the beat: causal evidence for dorsal premotor cortex (dPMC) role in beat imagery via transcranial magnetic stimulation (TMS)

Author(s): Lazzari G; Ferreri L; Cattaneo L; Penhune V; Lega C;

The ability to internally generate and maintain a rhythmic pulse, i.e., beat imagery, is a fundamental aspect of musical cognition. While recent theories propose that premotor regions support internal temporal predictions during rhythm perception and imagery, direct causal evidence remains limited. In this study, we investigated the specific contributions ...

Article GUID: 41248776


Temporal and Sex-Related Differences in Knee Biomechanics Over the Course of the Varsity Athletic Season: Pre- and Postseason Knee Kinematics in Collegiate Varsity Athletes Using Kinect

Author(s): Joseph T; Babouras A; Zhao KY; Corban J; Martineau PA;

Background: Anterior cruciate ligament (ACL) tears can be a source of significant morbidity, with the potential for career-altering implications for athletes who sustain them. Specific knee biomechanics during a drop vertical jump have been shown to be associated with an increased risk for ACL injury in collegiate varsity athletes. Presently, the evolutio ...

Article GUID: 41230424


Climate variability is an important driver of water treatability in a shallow reservoir

Author(s): Spence DS; Painter KJ; Nazemi A; Venkiteswaran JJ; Baulch HM;

Drinking water treatability is defined by multiple parameters that are strongly impacted by climatic and anthropogenic drivers. Working in a shallow reservoir in the Canadian Prairies, generalized additive models (GAMs) were applied to a 33-year dataset to identify drivers of interannual variability in multiple indicators of drinking water treatability. I ...

Article GUID: 41166973


A Novel Tool Condition Monitoring Technique of Determining Insert Flank Wear Width of Indexable Face Milling Tools Using On-Machine Laser Tool Setters

Author(s): Fang T; Chen Z; Feng H; Chen P; Chang Z;

Indexable face milling tools are often used to machine workpieces with large axial and radial depth of cuts, and thus, the inserts quickly wear out in machining. A kernel technique of smart machining is tool wear compensation, which is to regularly and automatically measure the insert radius/length with a laser tool setter on the machine table during mach ...

Article GUID: 41156415


Parental Language Mixing in Montreal: Rates, Predictors, and Relation to Infants Vocabulary Size

Author(s): Paquette A; Byers-Heinlein K;

Language mixing is a common feature of bilingual communication, yet its predictors and effects on children's vocabulary development remain debated. Most research has been conducted in contexts with clear societal and heritage languages, leaving open questions about language mixing in environments with two societal languages. Montreal provides a unique ...

Article GUID: 41153161


Quality Assessment of Health Information on Social Media During a Public Health Crisis: Infodemiology Study

Author(s): Haghighi R; Farhadloo M;

Background: The quality of health information on social media is a major concern, especially during the early stages of public health crises. While the quality of the results of the popular search engines related to particular diseases has been analyzed in the literature, the quality of health-related information on social media, such as X (formerly Twitt ...

Article GUID: 41135052


The Bug-Network (BugNet): A Global Experimental Network Testing the Effects of Invertebrate Herbivores and Fungal Pathogens on Plant Communities and Ecosystem Function in Open Ecosystems

Author(s): Kempel A; Adamidis GC; Anadón JD; Atkinson J; Auge H; Avtzis D; Bachelot B; Bashirzadeh M; Bota JL; Classen A; Constantinou I; Crawley M; de Bellis T; Dostal P; Ebeling A; Eisenhauer N; Eldridge DJ; Encina G; Estrada C; Everingham S; Fan ...

Plants are consumed by a variety of organisms, including herbivores and pathogens, which significantly impact plant biomass, diversity, community composition, and ecosystem functioning. While the impacts of vertebrate herbivores are well established, the effects of consumer groups such as insect ...

Article GUID: 41080499


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