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Nature vs nurture of glucose homeostasis trajectories in children from the ALSPAC study

Author(s): Gamache I; Fagbemi K; Harnois-Leblanc S; Greenwood CMT; Henderson M; Van Hulst A; Timpson NJ; Manousaki D;

Aims/hypothesis: Dysglycaemia in youth results from complex interactions between genetic and environmental factors, yet their individual and combined contributions remain unclear. We aimed to: (1) evaluate the predictive performance of polygenic risk scores (PRSs) for glycaemic traits from childh ...

Article GUID: 41986816


Reliability and Validity of Risk Assessment Tools for Violent Extremism: A Systematic Review

Author(s): Brouillette-Alarie S; Hassan G; Varela W; Danis E; Ousman S; Madriaza P; Pauls IL; Kilinc D; Pickup D; Pelzer R; Borokhovski E;

Assessment of the risk of engaging in a violent radicalization/extremism trajectory has evolved quickly in the last 10 years. Guided by what has been achieved in psychology and criminology, scholars from the field of preventing violent extremism (PVE) have tried to import key lessons from violenc ...

Article GUID: 41978672


Editorial: Social influences on ontogenetic development

Author(s): Rodriguez Buritica JM; van den Bos W; Eppinger B; Ciranka SK;

Article GUID: 41947957


Do They Feel Heard? A Study of Canadian Secondary School Students Voices Around Violent Extremism

Author(s): Dil Dilimulati M; Hossain Dhali H; Ghosh R;

This paper examines the perspectives and experiences of Canadian secondary school students on violent extremism. Through interviews with students (n = 36), the study highlights a significant lack of critical understanding of the topic. Although students perceive their teachers as competent, discussions on violent extremism are notably absent in classrooms ...

Article GUID: 41938795


Interpersonal Capitalization and Unmet Interpersonal Needs Among Adolescents at Varying Risk for Suicidal Ideation: A Daily Diary Study

Author(s): Perezmontemayor Cruz I; MacNeil S; Renaud J; Gouin JP;

Introduction: Adolescents at risk for suicidal ideation tend to report more unmet interpersonal needs, namely perceived burdensomeness and thwarted belongingness. Interpersonal capitalization-an interpersonal process involving disclosing a positive personal event to others and evaluating others' responsiveness to such disclosure-can promote positive a ...

Article GUID: 41928498


Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment

Author(s): Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T;

Background: Subcortical ischemic vascular cognitive impairment (SIVCI) is characterized by white matter hyperintensities (WMH) that contribute to executive dysfunction and increased risk of Alzheimer's disease. Cognitive reserve (CR) is the brain's ability to maintain cognitive performance despite pathology. Resting-state functional connectivity ( ...

Article GUID: 41929984


Assessing Port-related Greenhouse Gas Emissions and Mitigation Pathways Through a Comprehensive Framework Applied to the Vancouver Fraser Port Authority

Author(s): Wang Z; Su Y; Lu Z; An C;

Maritime transport is a major contributor to greenhouse gas (GHG) emissions, and ports play a critical role in shaping regional and national decarbonization pathways. This study develops a comprehensive framework to quantify both offshore and onshore GHG emissions associated with port activities and applies it to the Vancouver Fraser Port Authority (VFPA) ...

Article GUID: 41925888


eDNA Provides Accurate Population Abundance Estimates With Bioenergetics and Particle Mass-Balance Modelling

Author(s): Beaulieu J; Yates MC; Fraser DJ; Cristescu ME; Derry AM;

Anthropogenic activities have led to an unprecedented crisis in freshwater biodiversity loss. The capacity to monitor the abundance of wild populations is critical to conserving biodiversity, but conventional physical specimen collection methods are invasive, costly and labour-intensive. Environmental DNA (eDNA) offers a promising alternative, being easy ...

Article GUID: 41913704


Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner

Author(s): Hajiaghayi M; Gholizadeh F; Rahbari N; Emamnia N; Shih SCC; Darlington PJ;

Introduction: Cancers often drive T cells toward an exhausted state characterized by impaired cytotoxicity and upregulation of inhibitory receptors (PD-1, TIM-3, CD38) and transcriptional regulators (TOX, NFATc1). Repeated stimulation in vitro is used to model this process, reflecting chronic antigen exposure in the tumor microenvironment. Stress-derived ...

Article GUID: 41906691


Evaluation and Utilization of Aged Bacteria in MICP Technology

Author(s): Fukue M; Lechowicz Z; Mulligan CN; Takeuchi S; Takeuchi H;

As a response to aging of cultured urease-producing microorganisms, the blending method was examined to obtain the required carbonate production amount using the apparent viability (Rcv) based on previous research. As a result, a significantly higher carbonate content than the amount of CaCl2 2H2O used was produced. Since this trend has been obtained in p ...

Article GUID: 41900613


Gambling and the COVID-19 pandemic in the province of Quebec (Canada): results from an online cross-sectional survey of people who had gambled within the last 12 months

Author(s): Brodeur M; Fortier MÈ; Carrier N; Audette-Chapdelaine S; Auger AM; Savard AC; Kairouz S;

Objectives: This article presents the quantitative phase of a two-phase mixed methods study. The main objective of this article is to examine how the COVID-19 pandemic affected adult gamblers' gambling behaviours and mental health in Quebec. Design: A cross-sectional online survey was used to collect data. Setting: Quebec (Canada). Participants: A ...

Article GUID: 41887629


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