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Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact

Author(s): Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H;

Background"Inflammaging" describes chronic low-grade inflammation observed in aging individuals. It may play a major role in neurodegeneration.ObjectiveTo assess blood inflammatory markers in older adults. We hypothesized that elevated inflammation would be found in some cognitively nor ...

Article GUID: 41358624


Comparing the impact of in-person vs. virtual 10-week family-based childhood obesity management program on anthropometric, cardiometabolic, and mental health outcomes

Author(s): Heidl AJ; Sun D; Faustini C; Gierc M; Bains A; Cohen TR;

Objectives: To compare differences in patient outcomes in individuals living with overweight and obesity who attended a 10-week multidisciplinary program delivered virtually vs. participants who completed the program in-person. Methods: Data from 27 youth (8-18 years old) who attended virtual programming were matched by sex and body mass index (BMI) z-sc ...

Article GUID: 41332896


A comparison of municipal waste collection policies to optimize recycling rates: Evidence from England and Wales

Author(s): Wilansky J; Cao K;

This study investigated the effectiveness of municipal waste collection policies within England and Wales by examining how variations in local waste management strategies correlate with recycling rates. Using data from 297 council districts, we analysed the impact of different policy variables (frequency of residual waste and recycling collection, sorting ...

Article GUID: 41297338


Entrepreneurship as a driver of rural women s empowerment in Iran

Author(s): Rezaei-Moghaddam K; Fatemi M; Ghafouri M; Golkarfard M;

Entrepreneurship is a key driver of empowerment, particularly in rural areas, as it creates opportunities for self-sufficiency and sustainable development. It enables individuals to overcome barriers, build capacity, and engage in participatory activities that foster economic and social growth. This study aimed to analyze entrepreneurship and the empowerm ...

Article GUID: 41290906


Tri-Functional CRISPR Screen Reveals Overexpression of em QDR2 /em and em QDR3 /em Transporters Increase Fumaric Acid Production in em Kluyveromyces marxianus /em

Author(s): Thornbury M; Omran RP; Kumar L; Knoops A; Abushahin R; Whiteway M; Martin VJJ;

Organic acids such as fumaric acid are widely used in the food and beverage industry as acidulants and preservatives, while also serving as versatile precursors for industrially relevant compounds. Fumaric acid is still predominantly produced through petroleum-derived processes. To enhance production efficiency and diversify supply, we are engineering Klu ...

Article GUID: 41277095


Substituted diphenylamine antioxidants and synthetic phenolic antioxidants in leachate from domestic landfills in China: Occurrence and removal via treatment

Author(s): Zhang LH; Chen F; Zhang XM; Zhang X; Liang B; Bai SS; Zhang ZF; Li YF; Ren NQ;

Substituted diphenylamine antioxidants (SDPAs) and synthetic phenolic antioxidants (SPAs), widely used in rubber and consumer products, pose growing environmental concerns. This study evaluated the occurrence and release of 43 SDPAs and 4 SPAs in raw leachate and treated effluent from 18 municipal landfills across China. Results showed 17 SDPAs and 1 SPA ...

Article GUID: 41270417


From pollution barriers to health buffers: Rethinking building airtightness under climate variability

Author(s): Fu N; Zhang R; Haghighat F; Kumar P; Cao SJ;

Climate change is reshaping indoor-outdoor pollution dynamics, yet current building standards rarely reflect this shift. In rapidly urbanizing regions with high ambient PM2.5 levels, building airtightness offers an underutilized strategy to mitigate indoor exposure and associated health burdens. An analysis of 36 major Chinese cities across five climate z ...

Article GUID: 41252997


Methotrexate plus low-dose prednisolone compared with high-dose corticosteroid therapy in the management of idiopathic granulomatous mastitis

Author(s): Shojaee L; Nafissi N; Roodposhti FN; Shakeriastani K; Shakeriastani K;

Purpose: Idiopathic granulomatous mastitis (IGM) is a chronic, relapsing inflammatory breast disease of unknown etiology. Its unpredictable course and unclear pathogenesis have made treatment a persistent clinical challenge. This study aimed to evaluate treatment outcomes in patients with IGM, focusing on extending remission periods and reducing relapse r ...

Article GUID: 41251719


Imagining the beat: causal evidence for dorsal premotor cortex (dPMC) role in beat imagery via transcranial magnetic stimulation (TMS)

Author(s): Lazzari G; Ferreri L; Cattaneo L; Penhune V; Lega C;

The ability to internally generate and maintain a rhythmic pulse, i.e., beat imagery, is a fundamental aspect of musical cognition. While recent theories propose that premotor regions support internal temporal predictions during rhythm perception and imagery, direct causal evidence remains limited. In this study, we investigated the specific contributions ...

Article GUID: 41248776


Temporal and Sex-Related Differences in Knee Biomechanics Over the Course of the Varsity Athletic Season: Pre- and Postseason Knee Kinematics in Collegiate Varsity Athletes Using Kinect

Author(s): Joseph T; Babouras A; Zhao KY; Corban J; Martineau PA;

Background: Anterior cruciate ligament (ACL) tears can be a source of significant morbidity, with the potential for career-altering implications for athletes who sustain them. Specific knee biomechanics during a drop vertical jump have been shown to be associated with an increased risk for ACL injury in collegiate varsity athletes. Presently, the evolutio ...

Article GUID: 41230424


Climate variability is an important driver of water treatability in a shallow reservoir

Author(s): Spence DS; Painter KJ; Nazemi A; Venkiteswaran JJ; Baulch HM;

Drinking water treatability is defined by multiple parameters that are strongly impacted by climatic and anthropogenic drivers. Working in a shallow reservoir in the Canadian Prairies, generalized additive models (GAMs) were applied to a 33-year dataset to identify drivers of interannual variability in multiple indicators of drinking water treatability. I ...

Article GUID: 41166973


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