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From periodontitis to neurodegeneration: Can probiotics modulate the em P. gingivalis /em -amyloid pathway in Alzheimer s disease?

Author(s): Sharif-Askari Z; Atoui K; El Zein W; Rizk M; Sharif Askari E;

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the gradual destruction of cognitive and behavioral functions. Despite the continuous research efforts, there is still no cure for this disease. In recent years, researchers have investigated Porphyromonas gingivalis (P. gingivalis) as a potential cause of AD. P. gingivalis-lipo ...

Article GUID: 41940869


Perceived Partner Responsiveness is Associated with Longitudinal Changes in Circulating Inflammatory Biomarkers Among Caregiving Mothers in Midlife

Author(s): Gouin JP; Sánchez-Carro Y; Cruz IP; MacNeil S;

Positive social relationships are linked to better health outcomes. Beyond global evaluations of relationship quality, little is known about how specific interpersonal processes may influence biological pathways promoting optimal health outcomes. Perceived partner responsiveness (PPR) is an interpersonal process through which an individual comes to believ ...

Article GUID: 41876038


Gaza: rethinking and decolonizing mental health responses in humanitarian emergencies

Author(s): Mc Mahon A; Merchant H; Alkhatib S; Khanyari S; Alami T; Sader E; Nachabe J; El-Khoury J; Jabr S;

Longstanding armed conflicts generate distinctive psychological wounds, transforming collective bonds and reconfiguring individuals' perceptions of identity, security, and trust, enduring. The occupied Palestinian territories exemplify this violence, as prolonged occupation has produced deep, ...

Article GUID: 41681124


Biological sex and bilingualism: Its impact on risk and resilience for dementia

Author(s): Calvo N; Phillips N; Bialystok E; Einstein G;

Introduction: The relationship between biological sex, considered a risk factor for Alzheimer's disease (AD), and bilingualism, a resilience factor, is unclear. We assessed this relationship in 335 individuals with mild cognitive impairment (MCI) in a Canadian cohort. Methods: We used univariate analysis and structural equation modelling to study the ...

Article GUID: 41573422


Peripheral inflammation in a Canadian cohort of neurodegenerative conditions: Occurrence, determinants, and impact

Author(s): Seixas-Lima B; Rosa-Neto P; Phillips NA; Borrie M; Roncero CT; Lahiri D; Dori D; Eintracht S; Chertkow H;

Background"Inflammaging" describes chronic low-grade inflammation observed in aging individuals. It may play a major role in neurodegeneration.ObjectiveTo assess blood inflammatory markers in older adults. We hypothesized that elevated inflammation would be found in some cognitively nor ...

Article GUID: 41358624


Effects of delayed post-polymerization on physical, chemical, and biological properties of a 3D printing interim resin

Author(s): Choi Y; Comeau P; Lim BS; Manso AP; Chung SH;

Objectives: This study evaluated the effects of delayed post-polymerization on color, degree of conversion (DC), flexural strength (FS), and cellular response of a 3D-printed dental interim resin. Methods: Specimens were divided into six groups based on delays of 0 h, 2 h, 4 h, 6 h, 8 h, and 10 h before post-polymerization. Color was characterized using ...

Article GUID: 41152035


The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss

Author(s): Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;

Introduction: Adipose tissue inflammation, driven in part by immune cells, may contribute to the elevated type 2 diabetes risk in adults with childhood-onset obesity (CO) compared to those with adult-onset obesity (AO). Weight loss can modify adipose tissue immune cell composition, but whether these changes differ by obesity onset remains unknown. Method ...

Article GUID: 40831565


Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?

Author(s): Turner L; Wanasinghe AI; Brunori P; Santosa S;

In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammation. Indeed, adipose tissue inflammation, which partially stems from macrophage infiltration and expr ...

Article GUID: 40533358


Sex Differences in the Association Between Subjective Social Status and Imaging Markers of Cardiac Inflammation and Fibrosis

Author(s): Sánchez-Carro Y; Moukarzel M; Friedrich MG; Gouin JP; Luu JM;

Objective: Beyond objective socioeconomic status (SES) indicators, subjective social status (SSS), an individual's subjective perception of their social standing relative to others, has been independently linked to cardiovascular disease (CVD) morbidity and mortality. Some studies also report sex differences in the association between SSS and CVD. Thi ...

Article GUID: 40471966


Exosome Innovations in Ophthalmology and Sjögren s Syndrome

Author(s): Wu KY; Dave A; Nirwal GK; Giunta M; Nguyen VDH; Tran SD;

Exosomes, a subset of extracellular vesicles, have emerged as potential therapeutic agents in ophthalmology due to their ability to modulate immune responses, facilitate cellular communication, and promote tissue repair. This chapter explores the potential applications of exosome-based therapies in corneal and anterior segment disorders, retinal diseases, ...

Article GUID: 40360847


Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats

Author(s): Meyer C; Schoettner K; Amir S;

Circadian dysfunction caused by exposure to aberrant light-dark conditions is associated with abnormal alcohol consumption in humans and animal models. Changes in drinking behavior have been linked to alterations in clock gene expression in reward-related brain areas, which could be attributed to either the effect of chronodisruption or alcohol. To date, ...

Article GUID: 39624490


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