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Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains com ...

Article GUID: 38596311


Design Optimization of a Hybrid-Driven Soft Surgical Robot with Biomimetic Constraints

Author(s): Roshanfar M; Dargahi J; Hooshiar A;

The current study investigated the geometry optimization of a hybrid-driven (based on the combination of air pressure and tendon tension) soft robot for use in robot-assisted intra-bronchial intervention. Soft robots, made from compliant materials, have gai ...

Article GUID: 38275456


Alternating direction method of multipliers for displacement estimation in ultrasound strain elastography

Author(s): Md Ashikuzzaman

CONCLUSIONS: A novel ultrasonic displacement tracking algorithm named ALTRUIST has been developed. The principal novelty of ALTRUIST is incorporating ADMM for optimizing an L 1 $L1$ -norm regularization-based cost function. ALTRUIST exhibits promising perfo ...

Article GUID: 38159299


Lactate's behavioral switch in the brain: An in-silico model

Author(s): Soltanzadeh M; Blanchard S; Soucy JP; Benali H;

Emerging evidence emphasizes lactate's involvement in both physiological processes (energy metabolism, memory, etc.) and disease (traumatic brain injury, epilepsy, etc.). Furthermore, the usefulness of mathematical modeling in deciphering underlying dyn ...

Article GUID: 37865309


Data-Weighted Multivariate Generalized Gaussian Mixture Model: Application to Point Cloud Robust Registration

Author(s): Ge B; Najar F; Bouguila N;

In this paper, a weighted multivariate generalized Gaussian mixture model combined with stochastic optimization is proposed for point cloud registration. The mixture model parameters of the target scene and the scene to be registered are updated iteratively ...

Article GUID: 37754943


Design optimization and experimental evaluation of a large capacity magnetorheological damper with annular and radial fluid gaps

Author(s): Abdalaziz M; Sedaghati R; Vatandoost H;

This paper presents an optimal design of a large-capacity Magnetorheological (MR) damper suitable for off-road vehicle applications. The damper includes an MR fluid bypass valve with both annular and radial gaps to generate a large damping force and dynamic ...

Article GUID: 37521729


Designing a multi-objective closed-loop supply chain: a two-stage stochastic programming, method applied to the garment industry in Montréal, Canada

Author(s): Shafiee Roudbari E; Fatemi Ghomi SMT; Eicker U;

The global population continues to grow, which expands demand for raw materials. Meanwhile, governments are developing circular economy strategies within cities and their industries. A circular economy utilizes refurbishing, reusing, remanufacturing, and re ...

Article GUID: 36747987


Optimizing Biodegradable Starch-Based Composite Films Formulation for Wound-Dressing Applications

Author(s): Delavari MM; Ocampo I; Stiharu I;

This paper utilizes response surface methodology (RSM) design-based analyses to optimize starch-based wound dressings that were characterized based on weight loss (WL%), swelling index (SI%), and mechanical strength (TS). The wound-dressing materials were p ...

Article GUID: 36557445


A flexible robust model for blood supply chain network design problem

Author(s): Khalilpourazari S; Hashemi Doulabi H;

World Health Organization (WHO) declared COVID-19 as a pandemic On March 12, 2020. Up to January 13, 2022, 320,944,953 cases of infection and 5,539,160 deaths have been reported worldwide. COVID-19 has negatively impacted the blood supply chain by drastical ...

Article GUID: 35474752


A Proposed Multi-Criteria Optimization Approach to Enhance Clinical Outcomes Evaluation for Diabetes Care: A Commentary

Author(s): Wan TTH; Matthews S; Luh H; Zeng Y; Wang Z; Yang L;

There are several challenges in diabetes care management including optimizing the currently used therapies, educating patients on selfmanagement, and improving patient lifestyle and systematic healthcare barriers. The purpose of performing a systems approac ...

Article GUID: 35372638


A multiobjective model for the green capacitated location-routing problem considering drivers' satisfaction and time window with uncertain demand

Author(s): Alamatsaz K; Ahmadi A; Mirzapour Al-E-Hashem SMJ;

Location-routing problem is a combination of facility location problem and vehicle routing problem. Numerous logistics problems have been extended to investigate greenhouse issues and costs related to the environmental impact of transportation activities. T ...

Article GUID: 34415526


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