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PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database

Author(s): Greco BM; Zapata G; Dandage R; Papkov M; Pereira V; Lefebvre F; Bourque G; Parts L; Kuzmin E;

Whole-genome duplication (WGD) events are common across various organisms; however, the retention and evolution of WGD paralogs is not fully understood. Quantitative measure of protein redistribution in response to the deletion of their WGD paralog provides insight into sources of gene retention. ...

Article GUID: 40580499


Multiphase OH Oxidation of Bisphenols: Chemical Transformation and Persistence in the Environment

Author(s): Yu J; Wu B; Peng C; Wentzell J; Wheeler MJ; Osagu JO; Zhang X; Li L; Abbatt JPD; Liggio J;

Bisphenol A (BPA) is a common endocrine disruptor widely found in commercial products. Despite negative human health effects, its usage is not fully banned worldwide with ongoing human exposure from sources including dust, aerosol particles, and surfaces. Although attention has been paid to the a ...

Article GUID: 40569786


Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment

Author(s): Grant N; Phillips N;

Mild cognitive impairment (MCI) and hearing loss (HL) have been separately associated with increased dementia risk. These highly co-occurring dementia risk factors are associated with aberrant functional brain connectivity. In individuals with HL aberrant functional connectivity has been associated with cognitive impairment. In individuals with MCI, aberr ...

Article GUID: 40567819


Hemodynamic correlates of fluctuations in neuronal excitability: A simultaneous Paired Associative Stimulation (PAS) and functional near infra-red spectroscopy (fNIRS) study

Author(s): Cai Z; Pellegrino G; Spilkin A; Delaire E; Uji M; Abdallah C; Lina JM; Fecteau S; Grova C;

Background: The relationship between task-related hemodynamic activity and brain excitability is poorly understood in humans as it is technically challenging to combine simultaneously non-invasive brain stimulation and neuroimaging modalities. Cortical excitability corresponds to the readiness to ...

Article GUID: 40567300


Metal Exposure, Bioaccumulation, and Toxicity Assessment in Sediments from the St. Lawrence River Before and After Remediation Using a Resuspension Technique

Author(s): Javid M; Mulligan CN; Lefranc M; Rosabal Rodriguez M;

This study, using Hyalella azteca and Chironomus riparius, evaluated the effects of exposure to heavy metal-contaminated sediments collected from the study area under three conditions: before remediation, after remediation, and suspended particulate matter (SPM). The selected toxicity tests allowed for the evaluation of biological responses across varying ...

Article GUID: 40559906


Viral Voices: Depictions of Women s Pain Experiences on Social Media

Author(s): Mazzocca K; Langmuir T; Manan J; Gagnon MM; Alberts NM;

TikTok is a popular social media platform increasingly used to disseminate health information and personal experiences, including among women with pain. Characterising health-related content can help understand how public perceptions are shaped and guide improvements in patient care. Although women with pain often seek information on social media, little ...

Article GUID: 40514002


Morphological characteristics of the thoracolumbar fascia: relationship to chronic low back pain and back extension strength

Author(s): Caron FP; Martin Smith C; Naghdi N; Iorio OC; Bertrand C; Fortin M;

Purpose: The purpose of this study was to investigate the relationship between different characteristics of the Thoracolumbar Fascia (TLF) (e.g., length, epimuscular fat distribution) with pain status and lumbar extension strength in a sample of participants with and without chronic low back pain (CLBP). Methodology: This cross-sectional study included 2 ...

Article GUID: 40498329


What is the role of non-surgical clinicians in the assessment and management of degenerative cervical myelopathy? - Insights from the RECODE-DCM peri-operative rehabilitation incubator

Author(s): Chauhan RV; Demetriades AK; Boerger TF; Lantz JM; Treanor C; Kalsi-Ryan S; Kumar V; Wood L; Plener J; Wilson N; Fortin M; Ammendolia C; Paus A; Dhillon RS; Davies B; Fehlings MG; Anderson DB;

Introduction: Evidence on degenerative cervical myelopathy (DCM) has frequently focussed on surgical management, overlooking the role of non-surgical clinicians. Their contributions in the patient journey remain largely underexplored in the literature. Research question: What is the role of non- ...

Article GUID: 40487873


Cannabidiol and multi-modal exercise for chemotherapy-induced peripheral neuropathy in cancer survivors

Author(s): Vigano M; Kubal S; Habib S; Samarani S; Kasvis P; Koudieh N; Kilgour R; Farzin H; Ahmad A; Vigano A; Costiniuk CT;

Purpose: This study explored the effectiveness of cannabidiol (CBD) alone and in combination with multi-modal exercise (MME) to improve signs and symptoms of chemotherapy-induced peripheral neuropathy (CIPN), quality of life (QoL), and functional capacity in cancer survivors. Methods: Cancer sur ...

Article GUID: 40464985


Trilingual families language strategies: potential predictors and effect on trilingual exposure

Author(s): Quirk E; Hadeed N; Byers-Heinlein K;

Family language strategies are approaches that parents adopt for language use with their multilingual children. In bilingual contexts, these strategies influence children's language exposure and development (Macleod et al., 2022). In the more complex context of trilingualism, how families settle on strategies and their relationship with exposure may d ...

Article GUID: 40443954


Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear-Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes

Author(s): Pinto SM; Cheung JPY; Samartzis D; Karppinen J; Zheng YP; Pang MYC; Fortin M; Wong AYL;

Background: Although individuals with chronic low back pain (CLBP) show increased fatty infiltration in the lumbar multifidus muscle (LMM), it remains unclear whether LMM changes are related to clinical outcomes (such as pain and disability) after considering confounders (spinal phenotypes, fear-avoidance beliefs [FABs] and insomnia). This study examined: ...

Article GUID: 40376565


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