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pH-Responsive Degradable Electro-Spun Nanofibers Crosslinked via Boronic Ester Chemistry for Smart Wound Dressings

Author(s): Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK; ...

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompat ...

Article GUID: 38989606


Design, Synthesis, and Acid-Responsive Disassembly of Shell-Sheddable Block Copolymer Labeled with Benzaldehyde Acetal Junction

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Jazani AM; Oh JK;

Smart nanoassemblies degradable through the cleavage of acid-labile linkages have attracted significant attention because of their biological relevance found in tumor tissues. Despite their high potential to achieve controlled/enhanced drug release, a syste ...

Article GUID: 38499007


Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

Author(s): Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett M ...

Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least ...

Article GUID: 37888959


The neurophysiology of closed-loop auditory stimulation in sleep: A magnetoencephalography study

Author(s): Jourde HR; Merlo R; Brooks M; Rowe M; Coffey EBJ;

Closed-loop auditory stimulation (CLAS) is a brain modulation technique in which sounds are timed to enhance or disrupt endogenous neurophysiological events. CLAS of slow oscillation up-states in sleep is becoming a popular tool to study and enhance sleep&# ...

Article GUID: 37675803


Inpatient Care Utilization Following Mobile Crisis Response Encounters Among Racial/Ethnic Minoritized Youth

Author(s): Lui JHL; Chen BC; Benson LA; Lin YR; Ruiz A; Lau AS;

Objective: There has been an increase in youth psychiatric emergencies and psychiatric inpatient hospitalizations in recent years. Mobile crisis responses (MCR) services offer an opportunity to meet acute youth mental health needs in the community and provi ...

Article GUID: 37422107


Context-induced renewal of passive but not active coping behaviours in the shock-probe defensive burying task

Author(s): Alexa Brown

Renewal is the return of extinguished responding after removal from the extinction context. Renewal has been extensively studied using classical aversive conditioning procedures that measure a passive freezing response to an aversive conditioned stimulus. H ...

Article GUID: 37095421


Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides

Author(s): Pontarelli A; Liu JT; Oh JK; Wilds CJ;

The protocols described in this article provide details regarding the synthesis and characterization of a disulfide containing linker phosphoramidite for terminal functionalization of synthetic oligonucleotides. The linker is first synthesized from 6-mercap ...

Article GUID: 36840706


A pH-Responsive phosphoprotein washing fluid for the removal of phenanthrene from contaminated peat moss in the cold region

Author(s): Yue R; An C; Ye Z; Li X; Li Q; Zhang P; Qu Z; Wan S;

Oil pollution is one of the major environmental concerns in the petroleum industry. In this study, a cheap food-grade sodium caseinate (NaCas) was used as a pH-responsive washing fluid in the remediation of phenanthrene (PHE) affected peat moss. The effects ...

Article GUID: 36455665


Mapping pontocerebellar connectivity with diffusion MRI

Author(s): Rousseau PN; Chakravarty MM; Steele CJ;

The cerebellum's involvement in cognitive, affective and motor functions is mediated by connections to different regions of the cerebral cortex. A distinctive feature of cortico-cerebellar loops that has been demonstrated in the animal work is a topogra ...

Article GUID: 36252913


Dual acting acid-cleavable self-assembling prodrug from hyaluronic acid and ciprofloxacin: A potential system for simultaneously targeting bacterial infections and cancer

Author(s): Ibrahim UH; Devnarain N; Mohammed M; Omolo CA; Gafar MA; Salih M; Pant A; Shunmugam L; Mocktar C; Khan R; Oh JK; Govender T; ...

The incidence and of bacterial infections, and resulting mortality, among cancer patients is growing dramatically, worldwide. Several therapeutics have been reported to have dual anticancer and ant ...

Article GUID: 36150574


Transcriptional Profiling of the Candida albicans Response to the DNA Damage Agent Methyl Methanesulfonate

Author(s): Feng Y; Zhang Y; Li J; Omran RP; Whiteway M; Feng J;

The infection of a mammalian host by the pathogenic fungus Candida albicans involves fungal resistance to reactive oxygen species (ROS)-induced DNA damage stress generated by the defending macrophages or neutrophils. Thus, the DNA damage response in C. albi ...

Article GUID: 35886903


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