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Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains com ...

Article GUID: 38596311


Brain PET Imaging in Small Animals: Tracer Formulation, Data Acquisition, Image Reconstruction, and Data Analysis

Author(s): Bdair H; Kang MS; Ottoy J; Aliaga A; Kunach P; Singleton TA; Blinder S; Soucy JP; Leyton M; Rosa-Neto P; Kostikov A; ...

Positron emission tomography (PET) is a noninvasive functional imaging modality that involves in vivo detection of spatiotemporal changes in the binding of radioactive pharmaceuticals (a.k.a. PET t ...

Article GUID: 38006502


The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol.

Author(s): Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Psychoneuroendocrinology. 2020 Feb 07;115:104606 Authors: Maseroli E, Santangelo A, Lara-Fontes B, Quintana GR, Mac Cionnaith CE, Casarrubea M, Ricca V, Maggi M, Vignozzi L, Pfaus JG

Article GUID: 32087523


Aromatization Is Not Required for the Facilitation of Appetitive Sexual Behaviors in Ovariectomized Rats Treated With Estradiol and Testosterone.

Author(s): Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Front Neurosci. 2019;13:798 Authors: Jones SL, Rosenbaum S, Gardner Gregory J, Pfaus JG

Article GUID: 31447629


Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.

Author(s): Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheimer’s ...

Eur J Nucl Med Mol Imaging. 2018 06;45(6):1021-1030 Authors: Pascoal TA, Mathotaarachchi S, Shin M, Park AY, Mohades S, Benedet AL, Kang MS, Massarweh G, Soucy JP, Gauthier S, Rosa-Neto P, Alzheim ...

Article GUID: 29396637


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