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Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues

Author(s): Ndiaye NA; Shamleh SA; Casale D; Castaneda-Ouellet S; Laplante I; Robinson MJF; Samaha AN; ...

Rationale: When people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include conditioned stimuli (CSs) signaling drug delivery a ...

Article GUID: 38767684


Augmenting glutamatergic, but not dopaminergic, activity in the nucleus accumbens shell disrupts responding to a discrete alcohol cue in an alcohol context

Author(s): Valyear MD; Brown A; Deyab G; Villaruel FR; Lahlou S; Caporicci-Dinucci N; Chaudhri N;

Discrete alcohol cues and contexts are relapse triggers for people with alcohol use disorder exerting particularly powerful control over behaviour when they co-occur. Here, we investigated the neural substrates subserving the capacity for alcohol-associated ...

Article GUID: 38185906


Surgical margin assessment of bone tumours: A systematic review of current and emerging technologies

Author(s): Shoman H; Al-Kassmy J; Ejaz M; Matta J; Alakhras S; Kahla K; D' Acunto M;

Osteosarcoma is the most common malignant tumour of the bone. Complete surgical excision is critical to achieve optimal outcomes and lower recurrence rates. However, accurate assessment of tumour margins remains a challenge and multiple technologies are emp ...

Article GUID: 36845345


Acute food deprivation-induced relapse to heroin seeking after short and long punishment-imposed abstinence in male rats

Author(s): Borges C; Inigo F; Quteishat N; Charles J; Ah-Yen E; U S;

Rational: Stress is a major trigger for drug relapse in humans and animal models, even after prolonged abstinence. However, animal models for stress-induced relapse were criticized for the lack of predictive and face validity.
...

Article GUID: 35951079


The Role of Context Conditioning in the Reinstatement of Responding to an Alcohol-Predictive Conditioned Stimulus

Author(s): LeCocq MR; Sun S; Chaudhri N;

Re-exposure to an unconditioned stimulus (US) can reinstate extinguished conditioned responding elicited by a conditioned stimulus (CS). We tested the hypothesis that the reinstatement of responding to an appetitive CS is driven by an excitatory association ...

Article GUID: 34852244


Assessing the role of cortico-thalamic and thalamo-accumbens projections in the augmentation of heroin seeking in chronically food-restricted rats.

Author(s): Chisholm A; Rizzo D; Fortin É; Moman V; Quietshat N; Romano A; Capolicchio T; Shalev U;

Drug addiction is a chronic disorder characterized by compulsive drug seeking and involves repetitive cycles of compulsive drug use, abstinence, and relapse. In both human and animal models of addiction, chronic food restriction increases rates of relapse. ...

Article GUID: 33219004


Comparing ABA, AAB, and ABC Renewal of Appetitive Pavlovian Conditioned Responding in Alcohol- and Sucrose-Trained Male Rats.

Author(s): Khoo SY, Sciascia JM, Brown A, Chaudhri N

Front Behav Neurosci. 2020;14:5 Authors: Khoo SY, Sciascia JM, Brown A, Chaudhri N

Article GUID: 32116588


Context controls the timing of responses to an alcohol-predictive conditioned stimulus.

Author(s): Valyear MD, Chaudhri N

Behav Processes. 2020 Feb 01;:104061 Authors: Valyear MD, Chaudhri N

Article GUID: 32017964


Considering Drug-Associated Contexts in Substance Use Disorders and Treatment Development.

Author(s): LeCocq MR, Randall PA, Besheer J, Chaudhri N

Neurotherapeutics. 2020 Jan 02;: Authors: LeCocq MR, Randall PA, Besheer J, Chaudhri N

Article GUID: 31898285


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