1 Department of Mechanical, Industrial, and Aerospace Engineering, Concordia University, Montreal, QC H3G 1M8, Canada.
2 Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada.
3 Department of Electrical Engineering, École de Technologie Supérieure, 1100 Notre Dame West, Montreal, QC H3C 1K3, Canada.

This review paper delves into the realm of hybrid cellulose-based materials and their applications in 2D nano-delivery systems. Cellulose, recognized for its biocompatibility, versatility, and renewability, serves as the core matrix for these nanomaterials. The paper offers a comprehensive overview of the latest advancements in the creation, analysis, and application of these materials, emphasizing their significance in nanotechnology and biomedical domains. It further illuminates the integration of nanomaterials and advanced synthesis techniques that have significantly improved the mechanical, chemical, and biological properties of hybrid cellulose-based materials.