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Imidazole-Mediated Dual Location Disassembly of Acid-Degradable Intracellular Drug Delivery Block Copolymer Nanoassemblies

Author(s): Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK;

Acid-degradable (or acid-cleavable) polymeric nanoassemblies have witnessed significant progress in anti-cancer drug delivery. However, conventional nanoassemblies designed with acid-cleavable linkages at a single location have several challenges, such as, ...

Article GUID: 34050688


Direct Polymerization Approach to Synthesize Acid-Degradable Block Copolymers Bearing Imine Pendants for Tunable pH-Sensitivity and Enhanced Release.

Author(s): Hu X, Oh JK

The development of effective approaches to synthesize smart amphiphilic block copolymers (ABPs) exhibiting acid-responsive degradation through the cleavage of acid-labile imine bonds is extensively explored for controlled release of encapsulated biomolecule ...

Article GUID: 32964550


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