Author(s): Sun B; Yang JG; Wang Z; Wang Z; Feng W; Li X; Liu SN; Li J; Zhu YQ; Zhang P; Wang W;

Background: The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in-depth research on the selective mechanism of m6A methylation is still lacking. Methods: In this research, meRIP sequencing, mRNA sequencing, meRIP, luciferase ...

Article GUID: 40051055

Author(s): Zhu FJ; Lu XM; Jia JW; Zhang X; Xing DF; Cai MH; Kallenborn R; Li YF; Muir DCG; Zhang ZF; Zhang X;

Spatial variations of atmospheric alkylated polycyclic aromatic hydrocarbons (Alk-PAHs) are key to understanding their long-range atmospheric transport (LRAT). However, limited Alk-PAHs data have hindered their LRAT characterizations on a global scale. In this study, 49 Alk-PAHs were measured in ...

Article GUID: 40025703

Author(s): Dos Santos DM; Rubira RJG; Salzedas GP; Kobal MB; Moreira LG; Toledo KA; Aoki PHB; DeWolf C; Camacho SA;

Pesticides have boosted agricultural productivity but pose significant risks to environmental and human health. The intensification of agriculture has driven widespread pesticide use, with 66 % of global consumption allocated to sugarcane, soybean and corn. Sugarcane, a major monoculture in Brazi ...

Article GUID: 40020292

Author(s): Park Y; Aycan O; Kadem L;

This study evaluates the fluid dynamics inside and outside transcatheter blood pump positioned in the aorta. We focus on the pump's impact on blood component damage and arterial wall stress. CFD simulations were performed for rotational speeds ranging from 6000 to 15000 rpm, with a blood flow rate of 1.6 L/min. Results show that significant blood dama ...

Article GUID: 40014031

Author(s): Murphy A; Elbarazi I; Horen N; Ismail-Allouche Z; Long T; McNeill A; Arafat C; England D;

Background: An increasing body of evidence highlights the utility of examining adverse childhood experiences (ACEs) utilizing person-centered analytical approaches, particularly for understanding the organization and co-occurrence of ACEs, and their contributions to risk, vulnerability, and the development of intervention efforts. Methods: In the first s ...

Article GUID: 40001056

Author(s): Zgaren A; Bouachir W; Bouguila N;

Zero-shot counting is a subcategory of Generic Visual Object Counting, which aims to count objects from an arbitrary class in a given image. While few-shot counting relies on delivering exemplars to the model to count similar class objects, zero-shot counting automates the operation for faster processing. This paper proposes a fully automated zero-shot me ...

Article GUID: 39997554

Author(s): Boa Sorte Silva NC; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy W; Lam K; Kramer AF; Liu-Ambrose T;

Introduction: Physical activity is associated with greater myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying this relationship remain understudied. Methods: We assessed cross-sectionally wh ...

Article GUID: 39989020

Author(s): Alizadeh M; Collins DL; Kersten-Oertel M; Xiao Y;

Purpose: As a portable and cost-effective imaging modality with better accessibility than Magnetic Resonance Imaging (MRI), transcranial sonography (TCS) has demonstrated its flexibility and potential utility in various clinical diagnostic applications, including Parkinson's disease and cerebrovascular conditions. To better understand the information ...

Article GUID: 39920905

Author(s): Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; Van Haaften-Visser DY; Nieuwenhuis ESS; Jackson SP; Fuchs SA; Wijk F; van Hasselt P;

Background: Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenicity and pathophysiology. To address this challenge, we propose a high-through ...

Article GUID: 39920830

Author(s): Kelman MJ; Renaud JB; McCarron P; Hoogstra S; Chow W; Wang J; Varga E; Patriarca A; Vaya AM; Visintin L; Nguyen T; De Boevre M; De Saeger S; Karanghat V; Vuckovic D; McMullin DR; Dall' Asta C; Ayeni K; Warth B; Huang M; Tittlemier S ...

Monitoring for mycotoxins in food or feed matrices is necessary to ensure the safety and security of global food systems. Due to a lack of standardized methods and individual laboratory priorities, most institutions have developed their own methods for mycotoxin determinations. Given the diversit ...

Article GUID: 39913989

Author(s): Read RL; Bechard N; Suturin V; Zuiderwijk A; Mellenthin M;

The PolyVent is an open source mechanical ventilator meant for research and education. It prioritizes openness, modularity, repairability, and modifiability. An ESP32 microcontroller controls a proportional valve which precisely modulates pressure and flow from a mixing chamber into the airway. This chamber is fed with pressurized oxygen and medical air. ...

Article GUID: 39895909