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5P Risk Classification Predicts Performance on Self-Reported but Not Objective Clinical Outcomes at 4-Weeks Post-Concussion in Children

Author(s): Teel E; Brossard-Racine M; Corbin-Berrigan LA; Gagnon I;

Objective: To determine if performance on symptom, cognitive, balance, fatigue, physical activity, and quality of life outcomes at 4-weeks post-injury in children with concussion differs based on acute 5P risk classification. Design: Prospective cohort. Setting: Laboratory. Patients: Sixty-two children (age: 13.27 ± 2.50 years; 29 (46.7%) females) with ...

Article GUID: 39988038


iSurgARy: A mobile augmented reality solution for ventriculostomy in resource-limited settings

Author(s): Asadi Z; Castillo JP; Asadi M; Sinclair DS; Kersten-Oertel M;

Global disparities in neurosurgical care necessitate innovations addressing affordability and accuracy, particularly for critical procedures like ventriculostomy. This intervention, vital for managing life-threatening intracranial pressure increases, is associated with catheter misplacement rates exceeding 30% when using a freehand technique. Such misplac ...

Article GUID: 39816703


A Concussion Management Policy Change Promoted Earlier Initiation of Rehabilitation Services and Improved Clinical Recovery Outcomes in Concussion

Author(s): Teel EF; Dobney D; Friedman D; Grilli L; Beaulieu C; Gagnon IJ;

Context: In line with emerging research, an interprofessional specialty concussion clinic instituted a policy change permitting earlier physiotherapy-based treatment entry. Our objective was to determine the effect of this policy change on concussion recovery outcomes. Design: Secondary analysis of prospectively collected clinical data. Methods: 600 you ...

Article GUID: 39798559


Brain serotonin, oxytocin, and their interaction: Relevance for eating disorders

Author(s): Ismaylova E; Nemoda Z; Booij L;

Introduction: Eating disorders are characterized by maladaptive eating behaviors and preoccupations around body shape, weight, and eating. The serotonin system has been among the most widely studied neurobiological factors in relation to eating disorders. Recent research also highlighted the role of oxytocin. Aims and methods: This article aims to review ...

Article GUID: 39745000


A protocol for trustworthy EEG decoding with neural networks

Author(s): Borra D; Magosso E; Ravanelli M;

Deep learning solutions have rapidly emerged for EEG decoding, achieving state-of-the-art performance on a variety of decoding tasks. Despite their high performance, existing solutions do not fully address the challenge posed by the introduction of many hyperparameters, defining data pre-processing, network architecture, network training, and data augment ...

Article GUID: 39549492


Comprehensive Analysis of Age- and Sex-Related Expression of the Chaperone Protein Sigma-1R in the Mouse Brain

Author(s): Tarmoun K; Lachance V; Le Corvec V; Bélanger SM; Beaucaire G; Kourrich S;

Sigma-1R (S1R) is a ubiquitously distributed protein highly expressed in the brain and liver. It acts as a ligand-inducible chaperone protein localized at the endoplasmic reticulum. S1R participates in several signaling pathways that oversee diverse cellular and neurological functions, such as calcium and proteome homeostasis, neuronal activity, memory, a ...

Article GUID: 39335377


Impact of Stimulation Frequency on Verbal Fluency Following Bilateral Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease

Author(s): Busteed L; García-Sánchez C; Pascual-Sedano B; Grunden N; Gironell A; Kulisevsky J; Pagonabarraga J;

Objective: The effects of stimulation frequency on verbal fluency (VF) following subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) are not well understood. The present study examines the impact stimulation frequency has on VF following bilateral STN-DBS in PD. ...

Article GUID: 39127889


Feasibility and acceptability of an adapted peer-based walking intervention for adults with moderate-to-severe traumatic brain injury

Author(s): Quilico EL; Wilkinson S; Duncan LR; Sweet SN; Alarie C; Bédard E; Gheta I; Brodeur CL; Colantonio A; Swaine BR;

Purpose: To examine the feasibility and acceptability of a 6-week peer-based walking intervention for adults with moderate-to-severe TBI with telehealth supports. Materials and methods: Pre-post feasibility trial with 18 community-dwelling adults (10 men; 8 women) with moderate-to-severe TBI age ...

Article GUID: 39051571


Open access segmentations of intraoperative brain tumor ultrasound images

Author(s): Behboodi B; Carton FX; Chabanas M; de Ribaupierre S; Solheim O; Munkvold BKR; Rivaz H; Xiao Y; Reinertsen I;

Purpose: Registration and segmentation of magnetic resonance (MR) and ultrasound (US) images could play an essential role in surgical planning and resectioning brain tumors. However, validating these techniques is challenging due to the scarcity of publicly accessible sources with high-quality gr ...

Article GUID: 39047165


The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity

Author(s): Goldfield GS; Cameron JD; Sigal RJ; Kenny GP; Prud' homme D; Ngu M; Alberga AS; Doucette S; Goldfield DB; Tulloch H; Thai H; Simas KR; Walsh J;

The brain derived-neurotrophic factor (BDNF) Val66Met polymorphism causes functional changes in BDNF, and is associated with obesity and some psychiatric disorders, but its relationship to health-related quality of life (HRQoL) remains unknown. This study examined, in youth with obesity, whether ...

Article GUID: 38997217


EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy

Author(s): Afnan J; Cai Z; Lina JM; Abdallah C; Delaire E; Avigdor T; Ros V; Hedrich T; von Ellenrieder N; Kobayashi E; Frauscher B; Gotman J; Grova C;

Electro/Magneto-EncephaloGraphy (EEG/MEG) source imaging (EMSI) of epileptic activity from deep generators is often challenging due to the higher sensitivity of EEG/MEG to superficial regions and to the spatial configuration of subcortical structures. We previously demonstrated the ability of the ...

Article GUID: 38994740


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