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Prioritizing treatment targets for youths with disruptive behaviours and callous-unemotional traits: a modified Delphi study

Author(s): Diep J; Chen E; Lui JHL;

Background: Youths with disruptive behaviours (DB) and callous-unemotional (CU) traits experience significant impairments and impose substantial costs on families and society. Treatment outcome studies of current DB treatments highlight the need for tailored treatments. Identifying priority treatment targets that integrate empirical evidence with stakehol ...

Article GUID: 42351288


A Systematic Review and Meta-Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia

Author(s): Walsh NA; Phillips EM; Páez A; Cross NE; Dang-Vu TT; Perrault AA;

Mounting evidence shows sex-based differences in sleep experiences and outcomes, including the prevalence of insomnia disorder. However, the impact of biological sex on brain oscillations during sleep remains poorly understood, especially in the context of insomnia disorder. This is a notable gap, given that neurophysiological aspects of sleep are associa ...

Article GUID: 42331757


Synthesis of Oligonucleotide Conjugates Employing a Diselenide Linker

Author(s): Tikoo S; Noronha AM; Wilds CJ;

In this study, we report the synthesis of an alkylene linker containing a terminal 2-cyanoethyl protected selenium functionality for coupling at the 5'-end of an oligonucleotide by solid phase synthesis for the preparation of oligonucleotide conjugates. Upon deprotection and cleavage from the solid support, quantitative formation of a 5'-diselenid ...

Article GUID: 42322227


Sex differences in the association of adverse childhood experiences with brain and cognition along a continuum of risk for Alzheimer s disease

Author(s): Perovic M; Phillips NA; Einstein G;

Introduction: Women make up two-thirds of people with Alzheimer's disease (AD). Research has focused on biological explanations for this sex difference, while contributions of psychosocial risk factors are less well understood. Methods: We examined sex differences in the effects of adverse childhood experiences (ACEs) on late-life cognition in groups ...

Article GUID: 42325010


From Sparse Nanoparticles to Graded Interfaces: Beyond Classical Descriptions of LiF Growth on Organic Semiconductors

Author(s): Oliviera P; Maye F; Turak A;

Small-molecule π $\pi$ -conjugated semiconductors provide an ordered platform for probing interfacial mechanisms in organic optoelectronics, where device performance and stability are dominated by interface effects. Lithium fluoride, despite its widespread use as an interlayer, remains paradoxical: essential for high device efficiencies yet governe ...

Article GUID: 42316423


Microsphere-Templated Conductive Syntactic Foams for Recyclable and Additively Manufactured Soft Electronics

Author(s): Petrossian G; Diouri Y; Xu B; Ebrahimi S; Pande A; Miquet-Westphal F; Xu H; Cicoira F;

Soft, conductive materials that simultaneously offer mechanical compliance, electrical conductivity, recyclability, and scalable manufacturing remain difficult to achieve. Here, we introduce recyclable, 3D-printable PEDOT:PSS syntactic foams based on polymer microspheres coated in situ, enabling precise control over porosity, mechanical properties, and el ...

Article GUID: 42310993


An integrated external communication framework (ECF) for wheelchair design: linking primary user requirements with perceptual dimensions

Author(s): Rasoulivalajoozi M; Farhoudi M;

Purpose: Wheelchairs should support not only safe and intuitive navigation but also positive social presence without reinforcing disability-related stereotypes. This study introduces a user-centred external communication framework (ECF) to guide the design of wheelchair external human-machine interfaces and their perceptual dimensions.Materials and method ...

Article GUID: 42300838


From Rapid Reviews to Rapid Living Evidence Synthesis: Lessons From COVID-19 Vaccine Effectiveness Reviews for Canadian Public Health Decision-Making

Author(s): Wu N; Joyal-Desmarais K; Linkins LA; Flórez ID; Bacon SL;

Background: The COVID-19 pandemic demanded evidence synthesis approaches that could keep pace with rapidly evolving science and urgent policy needs. Rapid reviews and living evidence syntheses (LES) emerged as critical methodological responses, yet limited guidance exists for teams undertaking such work, particularly regarding the operational challenges o ...

Article GUID: 42282099


No evidence of sex-specific responses to chemosensory risk assessment cues in Harts rivulus

Author(s): Brusseau AJP; Synnott FD; Nagl A; Morris J; Mathis A; Ramnarine IW; Crane AL; Brown GE;

Males and females, especially in species with more pronounced sexual dimorphisms, may face very different trade-offs between detecting and avoiding predation threats and the need to court potential mates. Within aquatic ecosystems, the use of reliable publicly available chemosensory risk assessment cues allows prey to assess local threats and optimize the ...

Article GUID: 42264418


Enhanced co-removal of nitrate and tetracycline from wastewater by iron-nitrogen-doped carbon: synergistic role of pyridinic nitrogen and iron

Author(s): Yang W; Wang X; Li H; Liu W; Chen Z; Ren B; Guo T; Guo J;

Co-pollution of nitrate and tetracycline (TC) poses a critical barrier to efficient biological treatment due to impaired electron transfer, diminished microbial metabolic activity, and disrupted community structure. To address this challenge, this study synthesized an iron-nitrogen-doped carbon material (Fe-NC) featuring electron-withdrawing pyridinic nit ...

Article GUID: 42259450


Low levels of organization and consistency in the home in middle childhood predicts cortisol levels and internalizing symptoms 12 years later among the offspring of parents with bipolar disorder

Author(s): Ellenbogen MA; Serravalle L; Hodgins S; Walker CD; Walker EF;

The offspring of parents with bipolar disorder (OBD) are at high risk for developing affective disorders. Low levels of organization and consistency in the home (parenting structure) is associated with increased behavioral problems and hypothalamic-pituitary-adrenal (HPA) reactivity in the OBD and thus may be an important developmental risk factor. We als ...

Article GUID: 42247738


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