Author(s): Memari E; Helfield B;

The recent and exciting success of anti-inflammatory therapies for ischemic heart disease (e.g. atherosclerosis) is hindered by the lack of site-specific and targeted therapeutic deposition. Microbubble-mediated focused ultrasound, which uses circulating, l ...

Article GUID: 38988819

Author(s): Ramezani G; Stiharu I; van de Ven TGM; Nerguizian V;

This review paper delves into the realm of hybrid cellulose-based materials and their applications in 2D nano-delivery systems. Cellulose, recognized for its biocompatibility, versatility, and renewability, serves as the core matrix for these nanomaterials. ...

Article GUID: 38667550

Author(s): Gholami Farashah MS; Javadi M; Soleimani Rad J; Shakouri SK; Asnaashari S; Dastmalchi S; Nikzad S; Roshangar L; ...

Purpose: Exosomes are natural nanoparticles that participate in intercellular communication through molecular transport. Recently, due to their membrane vesicular structure and surface proteins, ex ...

Article GUID: 38022800

Author(s): Caparros-Gonzalez RA; Essau C; Gouin JP; Pemau A; Galvez-Merlin A; de la Torre-Luque A;

Objectives: Asthma is a common chronic and burdensome disease which typically begins in childhood. The aim of this study was to assess perinatal and obstetric factors which may increase the risk of developing asthma in the offspring. Methods: Data from fiv ...

Article GUID: 37326102

Author(s): Memari E; Hui F; Yusefi H; Helfield B;

The local fluid dynamics experienced by circulating microbubbles vary across different anatomical sites, which can influence ultrasound-mediated therapeutic delivery efficacy. This study aimed to elucidate the effect of fluid flow rate in combination with r ...

Article GUID: 37150403

Author(s): He S; Singh D; Yusefi H; Helfield B;

In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia. Novel ultrasound-stimulated microbubbles offer a means to deli ...

Article GUID: 36559150

Author(s): Choi M; Jazani AM; Oh JK; Noh SM;

Nitric oxide (NO) plays a critical role as an important signaling molecule for a variety of biological functions, particularly inhibiting cell proliferation or killing target pathogens. To deliver active radical NO gaseous molecule whose half-life is a few ...

Article GUID: 35683912

Author(s): Huang HY; Skripka A; Zaroubi L; Findlay BL; Vetrone F; Skinner C; Oh JK; Cuccia LA;

Chronic wounds present a high risk of infection due to delayed and incomplete healing, leading to increased health risks and financial burden to health-care systems. Numerous approaches to promote wound healing have been extensively explored, especially the ...

Article GUID: 35019380

Author(s): Jazani AM; Shetty C; Movasat H; Bawa KK; Oh JK;

Acid-degradable (or acid-cleavable) polymeric nanoassemblies have witnessed significant progress in anti-cancer drug delivery. However, conventional nanoassemblies designed with acid-cleavable linkages at a single location have several challenges, such as, ...

Article GUID: 34050688

Author(s): Copp W, Pontarelli A, Wilds CJ

The chemical and self-assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli-responsive devices for a diverse array of applications. Amongst the various three-dimensional assemblies, DNA tetrahedra are o ...

Article GUID: 33506614

Author(s): Huang Y, Jazani AM, Howell EP, Reynolds LA, Oh JK, Moffitt MG

We demonstrate microfluidic manufacturing of glutathione (GSH)-responsive polymer nanoparticles (PNPs) with controlled in vitro pharmacological properties for selective drug delivery. This work leverages previous fundamental work on microfluidic control of ...

Article GUID: 33455300