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Thermotolerance in S. cerevisiae as a model to study extracellular vesicle biology

Author(s): Logan CJ; Staton CC; Oliver JT; Bouffard J; Kazmirchuk TDD; Magi M; Brett CL;

The budding yeast Saccharomyces cerevisiae is a proven model organism for elucidating conserved eukaryotic biology, but to date its extracellular vesicle (EV) biology is understudied. Here, we show yeast transmit information through the extracellular medium ...

Article GUID: 38711329


Bioretention Design Modifications Increase the Simulated Capture of Hydrophobic and Hydrophilic Trace Organic Compounds

Author(s): Rodgers TFM; Spraakman S; Wang Y; Johannessen C; Scholes RC; Giang A;

Stormwater rapidly moves trace organic contaminants (TrOCs) from the built environment to the aquatic environment. Bioretention cells reduce loadings of some TrOCs, but they struggle with hydrophilic compounds. Herein, we assessed the potential to enhance T ...

Article GUID: 38483320


Using 13C enriched acetate in isotope labelling incubation experiments: a note of caution

Author(s): Leone F; Imfeld A; Mirzaei Y; GĂ©linas Y;

Vapour-phase fumigation with HCl is routinely used to remove inorganic carbon in preparation for the measurement of the concentration and d13C value of organic carbon in a sample using elemental analysis coupled to an isotope ratio mass spectrometer. Acidif ...

Article GUID: 38097918


Criminal Code reform of HIV non-disclosure is urgently needed: Social science perspectives on the harms of HIV criminalization in Canada

Author(s): Hastings C; French M; McClelland A; Mykhalovskiy E; Adam B; Bisaillon L; Bogosavljevic K; Gagnon M; Greene S; Guta A; Hindmarch S; Kaida A; ...

The criminalization of HIV non-disclosure represents a significant issue of concern among people living with HIV, those working across the HIV sector, public health practitioners, and health and hu ...

Article GUID: 38087186


Brain PET Imaging in Small Animals: Tracer Formulation, Data Acquisition, Image Reconstruction, and Data Analysis

Author(s): Bdair H; Kang MS; Ottoy J; Aliaga A; Kunach P; Singleton TA; Blinder S; Soucy JP; Leyton M; Rosa-Neto P; Kostikov A; ...

Positron emission tomography (PET) is a noninvasive functional imaging modality that involves in vivo detection of spatiotemporal changes in the binding of radioactive pharmaceuticals (a.k.a. PET t ...

Article GUID: 38006502


New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines

Author(s): Orabi MAA; Orabi EA; Awadh AAA; Alshahrani MM; Abdel-Wahab BA; Sakagami H; Hatano T;

Polyphenols have a variety of phenolic hydroxyl and carbonyl functionalities that enable them to scavenge many oxidants, thereby preserving the human redox balance and preventing a number of oxidative stress-related chronic degenerative diseases. In our ong ...

Article GUID: 38001804


Background Checks: Disentangling Class, Race, and Gender in CRPG Character Creators

Author(s): Iantorno M; Consalvo M;

Character backgrounds are one of many elements players use to customize their protagonists in fantasy computer role-playing games. By documenting the narrative trappings, mechanical benefits, and hierarchical availability of character backgrounds in Arcanum ...

Article GUID: 37928454


Microfluidic Wound-Healing Assay for ECM and Microenvironment Properties on Microglia BV2 Cells Migration

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Microglia cells, as the resident immune cells of the central nervous system (CNS), are highly motile and migratory in development and pathophysiological conditions. During their migration, microglia cells interact with their surroundings based on the variou ...

Article GUID: 36832056


Structural determination and anticholinesterase assay of C-glycosidic ellagitannins from Lawsonia inermis leaves: A study supported by DFT calculations and molecular docking

Author(s): Orabi MAA; Orabi EA; Abdel-Sattar ES; English AM; Hatano T; Elimam H;

An ellagitannin monomer, lythracin M (1), and a dimer, lythracin D (2), along with eight known monomers (3-10) were isolated from Lawsonia inermis (Lythraceae) leaves. Lythracin M (1) is a C-glycosidic ellagitannin with a flavogallonyl dilactone moiety that ...

Article GUID: 36423882


Modeling hormonal contraception in female rats: a framework for studies in behavioral neurobiology

Author(s): Lacasse JM; Gomez-Perales E; Brake WG;

Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices ...

Article GUID: 35952797


Te(IV) bioreduction in the sulfur autotrophic reactor: Performance, kinetics and synergistic mechanism

Author(s): He Y; Guo J; Song Y; Chen Z; Lu C; Han Y; Li H; Hou Y;

A laboratory-scale sulfur autotrophic reactor (SAR) was first constructed for treating tellurite [Te(IV)] wastewater. The SAR had excellent Te(IV) bioreduction efficiency (90-96%) at 5-30 mg/L and conformed to the First-order kinetic model. The Te(IV) biore ...

Article GUID: 35228038


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