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Functional and structural characterization of an IclR family transcription factor for the development of dicarboxylic acid biosensors

Author(s): Pham C; Nasr MA; Skarina T; Di Leo R; Kwan DH; Martin VJJ; Stogios PJ; Mahadevan R; Savchenko A; ...

Prokaryotic transcription factors (TFs) regulate gene expression in response to small molecules, thus representing promising candidates as versatile small molecule-detecting biosensors valuable for ...

Article GUID: 38696354


CRISPR/Cas9 mediated gene editing of transcription factor ACE1 for enhanced cellulase production in thermophilic fungus Rasamsonia emersonii

Author(s): Singh V; Raheja Y; Basotra N; Sharma G; Tsang A; Chadha BS;

Background: The filamentous fungus Rasamsonia emersonii has immense potential to produce biorefinery relevant thermostable cellulase and hemicellulase enzymes using lignocellulosic biomass. Previously in our lab, a hyper-cellulase producing strain of R. eme ...

Article GUID: 37658430


The chimeric GaaR-XlnR transcription factor induces pectinolytic activities in the presence of D-xylose in Aspergillus niger

Author(s): Kun RS; Garrigues S; Di Falco M; Tsang A; de Vries RP;

Aspergillus niger is a filamentous fungus well known for its ability to produce a wide variety of pectinolytic enzymes, which have many applications in the industry. The transcriptional activator GaaR is induced by 2-keto-3-deoxy-L-galactonate, a compound d ...

Article GUID: 34236481


Biosynthesis of Alkylcitric Acids in Aspergillus niger Involves Both Co-localized and Unlinked Genes.

Author(s): Palys S, Pham TTM, Tsang A

Front Microbiol. 2020;11:1378 Authors: Palys S, Pham TTM, Tsang A

Article GUID: 32695080


Evolutionary Transition of GAL Regulatory Circuit from Generalist to Specialist Function in Ascomycetes.

Author(s): Choudhury BI, Whiteway M

Trends Microbiol. 2018 08;26(8):692-702 Authors: Choudhury BI, Whiteway M

Article GUID: 29395731


W361R mutation in GaaR, the regulator of D-galacturonic acid-responsive genes, leads to constitutive production of pectinases in Aspergillus niger.

Author(s): Alazi E, Niu J, Otto SB, Arentshorst M, Pham TTM, Tsang A, Ram AFJ

Microbiologyopen. 2019 May;8(5):e00732 Authors: Alazi E, Niu J, Otto SB, Arentshorst M, Pham TTM, Tsang A, Ram AFJ

Article GUID: 30298571


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