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The Effect of a 10-Week Electromyostimulation Intervention with the StimaWELL 120MTRS System on Multifidus Morphology and Function in Chronic Low Back Pain Patients: A Randomized Controlled Trial

Author(s): Wolfe D; Rosenstein B; Dover G; Boily M; Fortin M;

Background: Chronic low back pain (CLBP) patients present with morphological and functional deficits to the lumbar multifidus. Electromyostimulation (EMS) can be used to improve activation and strength in atrophied skeletal muscle, but its effect on multifidus morphology and function in CLBP patients is understudied. The aims of this study were to compare ...

Article GUID: 41283552


Tri-Functional CRISPR Screen Reveals Overexpression of em QDR2 /em and em QDR3 /em Transporters Increase Fumaric Acid Production in em Kluyveromyces marxianus /em

Author(s): Thornbury M; Omran RP; Kumar L; Knoops A; Abushahin R; Whiteway M; Martin VJJ;

Organic acids such as fumaric acid are widely used in the food and beverage industry as acidulants and preservatives, while also serving as versatile precursors for industrially relevant compounds. Fumaric acid is still predominantly produced through petroleum-derived processes. To enhance production efficiency and diversify supply, we are engineering Klu ...

Article GUID: 41277095


Substituted diphenylamine antioxidants and synthetic phenolic antioxidants in leachate from domestic landfills in China: Occurrence and removal via treatment

Author(s): Zhang LH; Chen F; Zhang XM; Zhang X; Liang B; Bai SS; Zhang ZF; Li YF; Ren NQ;

Substituted diphenylamine antioxidants (SDPAs) and synthetic phenolic antioxidants (SPAs), widely used in rubber and consumer products, pose growing environmental concerns. This study evaluated the occurrence and release of 43 SDPAs and 4 SPAs in raw leachate and treated effluent from 18 municipal landfills across China. Results showed 17 SDPAs and 1 SPA ...

Article GUID: 41270417


Biotuner: A python toolbox integrating music theory and signal processing for harmonic analysis of physiological and natural time series

Author(s): Bellemare-Pepin A; Jerbi K;

Background: The Biotuner Toolbox is an open-source Python toolbox for biosignals that integrates concepts from neuroscience, music theory, and signal processing. It introduces a harmonic perspective on physiological oscillations by applying musical constructs such as consonance, rhythm, and scale construction. Methods: The core biotuner_object processes ...

Article GUID: 41269470


Use of a difference in fundamental frequency and spatial location beyond intelligibility purposes

Author(s): Adams R; Deroche MLD;

To extract a voice from a background of competing speakers, the human brain exploits voice pitch (harmonic cues) and spatial location (binaural cues) to separate speakers perceptually, and effectively attenuates the background (anything but the target voice). Quieter backgrounds are generally favourable to attentional and memory systems because they free ...

Article GUID: 41263630


Psychophysical evidence of the harmonic cancellation process and its relationship to pitch sensitivity and voice segregation

Author(s): Deroche M; Montagnese J; Khoury K; Iuliano R; Alemi R;

Harmonic cancellation is a putative mechanism in the auditory system that might contribute to the perception of the fundamental frequency (F0) of a complex tone and to the segregation of voices by their F0. This study aimed to provide more tangible evidence of its existence, acting like a comb-filter. Experiment 1 measured a masked detection threshold (MD ...

Article GUID: 41263633


First report of synthetic antioxidants in baby wipes: Insights into occurrence, sources, and infant exposure

Author(s): Wang X; Liu W; Wang J; Johannessen C; Zhang X; Xia K; Wu X; Liu Q;

Synthetic antioxidants (SAs), a group of emerging contaminants, have attracted great attention recently due to their widespread environmental occurrence and potential toxicity. Yet, there is a knowledge gap regarding their occurrence and associated infant exposure in baby wipes, one of the most frequently used baby products. Here, we analyzed SAs-includin ...

Article GUID: 41259909


Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy

Author(s): Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivière S; Caciagli L; Pana R; Weil AG; Grova C; Frauscher B; Schrader DV; Zhang Z; Concha L; Bernasc ...

Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 d ...

Article GUID: 41258102


From pollution barriers to health buffers: Rethinking building airtightness under climate variability

Author(s): Fu N; Zhang R; Haghighat F; Kumar P; Cao SJ;

Climate change is reshaping indoor-outdoor pollution dynamics, yet current building standards rarely reflect this shift. In rapidly urbanizing regions with high ambient PM2.5 levels, building airtightness offers an underutilized strategy to mitigate indoor exposure and associated health burdens. An analysis of 36 major Chinese cities across five climate z ...

Article GUID: 41252997


Methotrexate plus low-dose prednisolone compared with high-dose corticosteroid therapy in the management of idiopathic granulomatous mastitis

Author(s): Shojaee L; Nafissi N; Roodposhti FN; Shakeriastani K; Shakeriastani K;

Purpose: Idiopathic granulomatous mastitis (IGM) is a chronic, relapsing inflammatory breast disease of unknown etiology. Its unpredictable course and unclear pathogenesis have made treatment a persistent clinical challenge. This study aimed to evaluate treatment outcomes in patients with IGM, focusing on extending remission periods and reducing relapse r ...

Article GUID: 41251719


Parametric instability in discrete models of spatiotemporally modulated materials

Author(s): Wu J; Yousefzadeh B;

We investigate the phenomenon of parametric instability in discrete models of spatiotemporally modulated materials. These materials are celebrated in part because they exhibit nonreciprocal transmission characteristics. However, parametric instability may occur for strong modulations, or occasionally even at very small modulation amplitudes, and prevent t ...

Article GUID: 41250313


Imagining the beat: causal evidence for dorsal premotor cortex (dPMC) role in beat imagery via transcranial magnetic stimulation (TMS)

Author(s): Lazzari G; Ferreri L; Cattaneo L; Penhune V; Lega C;

The ability to internally generate and maintain a rhythmic pulse, i.e., beat imagery, is a fundamental aspect of musical cognition. While recent theories propose that premotor regions support internal temporal predictions during rhythm perception and imagery, direct causal evidence remains limited. In this study, we investigated the specific contributions ...

Article GUID: 41248776


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