Keyword search (4,163 papers available)

"Amir S" Authored Publications:

Title Authors PubMed ID
1 Disruptive effects of d-amphetamine on conditioned sexual inhibition in the male rat Germé K; Persad D; Petit-Robinson J; Amir S; Pfaus JG; 40232387
PSYCHOLOGY
2 Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats Meyer C; Schoettner K; Amir S; 39624490
PSYCHOLOGY
3 The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats Meyer C; Schoettner K; Amir S; 36620855
CSBN
4 Characterization of Affective Behaviors and Motor Functions in Mice With a Striatal-Specific Deletion of Bmal1 and Per2 Schoettner K; Alonso M; Button M; Goldfarb C; Herrera J; Quteishat N; Meyer C; Bergdahl A; Amir S; 35755440
HKAP
5 Thermoregulatory significance of immobility in the forced swim test Nadeau BG; Marchant EG; Amir S; Mistlberger RE; 35065081
PSYCHOLOGY
6 Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner de Zavalia N; Schoettner K; Goldsmith JA; Solis P; Ferraro S; Parent G; Amir S; 34702951
PSYCHOLOGY
7 In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders Ferraro S; de Zavalia N; Belforte N; Amir S; 34650409
CSBN
8 The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R 31522764
CSBN
9 Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats. Gavrila AM, Hood S, Robinson B, Amir S 28594962
CSBN
10 Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders. Pantazopoulos H, Gamble K, Stork O, Amir S 29887881
PSYCHOLOGY
11 Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain. Frederick A, Goldsmith J, de Zavalia N, Amir S 28423013
BIOLOGY
12 Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day. Harbour VL, Weigl Y, Robinson B, Amir S 24124556
PSYCHOLOGY
13 Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat. Harbour VL, Weigl Y, Robinson B, Amir S 25068868
PSYCHOLOGY
14 Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat. Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R 25309348
BIOLOGY
15 Stress-induced changes in the expression of the clock protein PERIOD1 in the rat limbic forebrain and hypothalamus: role of stress type, time of day, and predictability. Al-Safadi S, Al-Safadi A, Branchaud M, Rutherford S, Dayanandan A, Robinson B, Amir S 25338089
CSBN
16 Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N 25915475
CSBN
17 Glucocorticoids and Stress-Induced Changes in the Expression of PERIOD1 in the Rat Forebrain. Al-Safadi S, Branchaud M, Rutherford S, Amir S 26075608
CSBN
18 Circadian Rhythms and Psychopathology: From Models of Depression to Rhythms in Clock Gene Expression and Back Again. Verwey M, Al-Safadi S, Amir S 26195175
PSYCHOLOGY
19 From genes to chronotypes: the influence of circadian clock genes on our daily patterns of sleep and wakefulness. Verwey M, Amir S 27275497
CSBN
20 Exploring the role of locomotor sensitization in the circadian food entrainment pathway. Opiol H, de Zavalia N, Delorme T, Solis P, Rutherford S, Shalev U, Amir S 28301599
PSYCHOLOGY
21 Individual differences in circadian locomotor parameters correlate with anxiety- and depression-like behavior. Anyan J, Verwey M, Amir S 28763478
PSYCHOLOGY
22 Too Depressed to Swim or Too Afraid to Stop? A Reinterpretation of the Forced Swim Test as a Measure of Anxiety-Like Behavior. Anyan J, Amir S 29210364
PSYCHOLOGY
23 mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction Liu D; Stowie A; de Zavalia N; Leise T; Pathak SS; Drewes LR; Davidson AJ; Amir S; Sonenberg N; Cao R; 29555746
CSBN

 

Title:Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
Authors:Cao R,  Gkogkas CG,  de Zavalia N,  Blum ID,  Yanagiya A,  Tsukumo Y,  Xu H,  Lee C,  Storch KF,  Liu AC,  Amir S,  Sonenberg N
Link:https://www.ncbi.nlm.nih.gov/pubmed/25915475?dopt=Abstract
Publication:
Keywords:
PMID:25915475 Category:Nat Neurosci Date Added:2019-05-31
Dept Affiliation: CSBN
1 Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montreal, Canada.
2 Patrick Wild Centre, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK.
3 Center for Studies in Behavioral Neurobiology, Concordia University, Montreal, Canada.
4 Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
5 Department of Biological Sciences, University of Memphis, Memphis, Tennessee, USA.
6 Department of Biomedical Sciences, Neuroscience Program, College of Medicine, Florida State University, Tallahassee, Florida, USA.

Description:

Light-regulated translational control of circadian behavior by eIF4E phosphorylation.

Nat Neurosci. 2015 Jun;18(6):855-62

Authors: Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N

Abstract

The circadian (~24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. Light-induced gene expression is thought to be the molecular mechanism underlying clock entrainment. mRNA translation is a key step of gene expression, but the manner in which clock entrainment is controlled at the level of mRNA translation is not well understood. We found that a light- and circadian clock-regulated MAPK/MNK pathway led to phosphorylation of the cap-binding protein eIF4E in the mouse suprachiasmatic nucleus of the hypothalamus, the locus of the master circadian clock in mammals. Phosphorylation of eIF4E specifically promoted translation of Period 1 (Per1) and Period 2 (Per2) mRNAs and increased the abundance of basal and inducible PER proteins, which facilitated circadian clock resetting and precise timekeeping. Together, these results highlight a critical role for light-regulated translational control in the physiology of the circadian clock.

PMID: 25915475 [PubMed - indexed for MEDLINE]




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