Keyword search (4,163 papers available)

"An H" Authored Publications:

Title Authors PubMed ID
1 Impact of COVID-19 on incidence and trends of adverse events among hospitalised patients in Calgary, Canada: a retrospective chart review study Wu G; Eastwood CA; Cheligeer C; Southern DA; Zeng Y; Ghali WA; Bakal JA; Boussat B; Flemons W; Forster A; Xu Y; Quan H; 41592994
CONCORDIA
2 Establishing work productivity loss norms: Absenteeism and presenteeism in a Canadian working population Zhang W; Qian H; L' Heureux J; Johns G; Koehoorn M; Woodcock S; 41469277
JMSB
3 Preprocessing narrative texts in electronic medical records to identify hospital adverse events: A scoping review Jafarpour H; Wu G; Cheligeer CK; Yan J; Xu Y; Southern DA; Eastwood CA; Zeng Y; Quan H; 41072367
ENCS
4 Pseudocapacitive MXene@Fe-TA ternary mediator enhances denitrification via optimized electron transfer and microbial regulation in wastewater treatment Pan S; Wang X; Guo T; An H; Guo Y; Chen Z; Lian J; Guo J; 41043789
ENCS
5 A dataset from a coordinated multi-site laboratory study investigating the Hue-Heat-Hypothesis Bavaresco M; Cureau RJ; Pigliautile I; Barna E; Deme Belafi Z; Belussi L; Chinazzo G; Chiucchiù A; Danza L; Deng Z; Dong B; Gapski NH; Garlet L; Gnecco VM; Guo X; Pilehchi Ha P; Karimian H; Lamberts R; Liu S; da Costa Loeser B; Massucci C; Melo AP; Nagy BV; Ouf MM; Salamone F; Schweiker M; Pisello AL; 40973711
ENCS
6 Adaptive finite-time synchronized control of multi-robotic fiber placement system with model uncertainties and disturbances Zhang R; Wang Y; Xie W; Li P; Tan H; Jiang Y; 40461302
ENCS
7 Utilizing large language models for detecting hospital-acquired conditions: an empirical study on pulmonary embolism Cheligeer C; Southern DA; Yan J; Wu G; Pan J; Lee S; Martin EA; Jafarpour H; Eastwood CA; Zeng Y; Quan H; 40105654
ENCS
8 Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA) Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello C; Cynader M; Dang-Vu T; Das S; Dixon RA; Ducharme S; Einstein G; Evans AC; Fahnestock M; Feldman H; Ferland G; Finger E; Fisk JD; Fogarty J; Fon E; Gan-Or Z; Gauthier S; Greenwood C; Henri-Bellemare C; Herrmann N; Hogan DB; Hsiung R; Itzhak I; Jacklin K; Lanctôt K; Lim A; MacKenzie I; Masellis M; Maxwell C; McAiney C; McGilton K; McLaurin J; Mihailidis A; Mohades Z; Montero-Odasso M; Morgan D; Naglie G; Nygaard H; O' Connell M; Petersen R; Pilon R; Rajah MN; Rapoport M; Roach P; Robillard JM; Rogaeva E; Rosa-Neto P; Rylett J; Sadavoy J; St George-Hyslop P; Seitz D; Smith E; Stefanovic B; Vedel I; Walker JD; Wellington C; Whitehead V; Wittich W; 39636028
HKAP
9 Identifying personalized barriers for hypertension self-management from TASKS framework Yang J; Zeng Y; Yang L; Khan N; Singh S; Walker RL; Eastwood R; Quan H; 39143621
ENCS
10 Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells Bagheri H; Friedman H; Hadwen A; Jarweh C; Cooper E; Oprea L; Guerrier C; Khadra A; Collin A; Cohen-Adad J; Young A; Victoriano GM; Swire M; Jarjour A; Bechler ME; Pryce RS; Chaurand P; Cougnaud L; Vuckovic D; Wilion E; Greene O; Nishiyama A; Benmamar-Badel A; Owens T; Grouza V; Tuznik M; Liu H; Rudko DA; Zhang J; Siminovitch KA; Peterson AC; 39023138
CSBN
11 Translating the Interplay of Cognition and Physical Performance in COPD and Interstitial Lung Disease: Meeting Report and Literature Review Rozenberg D; Reid WD; Camp P; Campos JL; Dechman G; Davenport PW; Egan H; Fisher JH; Guenette JA; Gold D; Goldstein RS; Goodridge D; Janaudis-Ferreira T; Kaplan AG; Langer D; Marciniuk DD; Moore B; Orchanian-Cheff A; Otoo-Appiah J; Pepin V; Rassam P; Rotenberg S; Ryerson C; Spruit MA; Stanbrook MB; Stickland MK; Tom J; Wentlandt K; 38901488
HKAP
12 An Automated Single-Cell Droplet-Digital Microfluidic Platform for Monoclonal Antibody Discovery Ahmadi F; Tran H; Letourneau N; Little SR; Fortin A; Moraitis AN; Shih SCC; 38441226
BIOLOGY
13 How to present work productivity loss results from clinical trials for patients and caregivers? A mixed methods approach L' Heureux J; McTaggart-Cowan H; Johns G; Chen L; Steiner T; Tocher P; Sun H; Zhang W; 37276772
JMSB
14 Surgical margin assessment of bone tumours: A systematic review of current and emerging technologies Shoman H; Al-Kassmy J; Ejaz M; Matta J; Alakhras S; Kahla K; D' Acunto M; 36845345
ENCS
15 Design Principles in mHealth Interventions for Sustainable Health Behavior Changes: Protocol for a Systematic Review Yang L; Kuang A; Xu C; Shewchuk B; Singh S; Quan H; Zeng Y; 36811938
ENCS
16 Developing EMR-based algorithms to Identify hospital adverse events for health system performance evaluation and improvement: Study protocol Wu G; Eastwood C; Zeng Y; Quan H; Long Q; Zhang Z; Ghali WA; Bakal J; Boussat B; Flemons W; Forster A; Southern DA; Knudsen S; Popowich B; Xu Y; 36197944
ENCS
17 Data Analysis and Knowledge Mining of Machine Learning in Soil Corrosion Factors of the Pipeline Safety Zhao Z; Chen M; Fan H; Zhang N; 35571701
ENCS
18 Application of Machine Learning in the Reliability Evaluation of Pipelines for the External Anticorrosion Coating Zhao Z; Chen M; Fan H; Zhang N; 35371236
ENCS
19 Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab Chertkow H; Rockwood K; Hogan DB; Phillips N; Montero-Odasso M; Amanullah S; Black S; Bocti C; Borrie M; Feldman H; Freedman M; Hsiung R; Kirk A; Masellis M; Nygaard H; Rajji T; Verret L; 34912492
PSYCHOLOGY
20 COSORE: A community database for continuous soil respiration and other soil-atmosphere greenhouse gas flux data. Bond-Lamberty B, Christianson DS, Malhotra A, Pennington SC, Sihi D, AghaKouchak A, Anjileli H, Altaf Arain M, Armesto JJ, Ashraf S, Ataka M, Baldocchi D, Andrew Black T, Buchmann N, Carbone MS, Chang SC, Crill P, Curtis PS, Davidson EA, Desai AR, Drake JE, El-Madany TS, Gavazzi M, Görres CM, Gough CM, Goulden M, Gregg J, Gutiérrez Del Arroyo O, He JS, Hirano T, Hopple A, Hughes H, Järveoja J, Jassal R, Jian J, Kan H, Kaye J, Kominami Y, Liang N, Lipson D, Macdonald CA, Maseyk K, Mathes K, Mauritz M, Mayes 33026137
ENCS
21 Antagonistic interactions between two MAP kinase cascades in plant development and immune signaling. Sun T, Nitta Y, Zhang Q, Wu D, Tian H, Lee JS, Zhang Y 29789386
BIOLOGY
22 Effects of pool size and spacing on burning rate and flame height of two square heptane pool fires. Wan H, Gao Z, Ji J, Zhang Y, Li K, Wang L 30776594
ENCS
23 Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response. Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M 30530734
PERFORM

 

Title:Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.
Authors:Islam ATebbji FMallick JRegan HDumeaux VOmran RPWhiteway M
Link:https://www.ncbi.nlm.nih.gov/pubmed/30530734?dopt=Abstract
DOI:10.1534/genetics.118.301769
Publication:Genetics
Keywords:Candida albicansMms21filamentationstress responsesumoylation
PMID:30530734 Category:Genetics Date Added:2019-06-04
Dept Affiliation: PERFORM
1 Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
2 Infectious Centre de Recherche en Infectiologie (CRI), Centre Hospitalier Universitaire de Quebec (CHUQ) Research Center, University Laval, Quebec City, Quebec G1V 4G2, Canada.
3 Prevention Evaluation Rehabilitation Formation (PERFORM) Centre, Concordia University, Montreal, Quebec H4B 1R6, Canada.
4 Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada malcolm.whiteway@concordia.ca.

Description:

Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.

Genetics. 2019 02;211(2):579-595

Authors: Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Abstract

In the life cycle of the fungal pathogen Candida albicans, the formation of filamentous cells is a differentiation process that is critically involved in host tissue invasion, and in adaptation to host cell and environmental stresses. Here, we have used the Gene Replacement And Conditional Expression library to identify genes controlling invasiveness and filamentation; conditional repression of the library revealed 69 mutants that triggered these processes. Intriguingly, the genes encoding the small ubiquitin-like modifier (SUMO) E3 ligase Mms21, and all other tested members of the sumoylation pathway, were both nonessential and capable of triggering filamentation upon repression, suggesting an important role for sumoylation in controlling filamentation in C. albicans We have investigated Mms21 in detail. Both Mms21 nulls (mms21?/?) and SP [Siz/Pias (protein inhibitor of activated signal transducer and activator of transcription)] domain (SUMO E3 ligase domain)-deleted mutants displayed invasiveness, filamentation, and abnormal nuclear segregation; filament formation occurred even in the absence of the hyphal transcription factor Efg1. Transcriptional analysis of mms21?/? showed an increase in expression from two- to eightfold above that of the wild-type for hyphal-specific genes, including ECE1, PGA13, PGA26, HWP1, ALS1, ALS3, SOD4, SOD5, UME6, and HGC1 The Mms21-deleted mutants were unable to recover from DNA-damaging agents like methyl methane sulfonate, hydroxyurea, hydrogen peroxide, and UV radiation, suggesting that the protein is important for genotoxic stress responses. In addition, the mms21?/? mutant displayed sensitivity to cell wall and thermal stresses, and to different antifungal drugs. All these findings suggest that Mms21 plays important roles in cellular differentiation, DNA damage and cellular stress responses, and in response to antifungal drugs.

PMID: 30530734 [PubMed - indexed for MEDLINE]





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